SB 408124

Pricing Availability Delivery Time Qty
Cat.No. 1963 - SB 408124 | C19H18F2N4O | CAS No. 288150-92-5
Description: Selective non-peptide OX1 antagonist
Chemical Name: N-(6,8-Difluoro-2-methyl-4-quinolinyl)-N'-[4-(dimethylamino)phenyl]urea
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Selective non-peptide orexin OX1 receptor antagonist (Kb values are 21.7 and 1405 nM for human OX1 and OX2 receptors respectively). Blocks orexin-A induced grooming following oral administration in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Compound Libraries

SB 408124 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 356.37
Formula C19H18F2N4O
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 288150-92-5
PubChem ID 4331799
InChI Key JTARFZSNUAGHRB-UHFFFAOYSA-N
Smiles CN(C)C1=CC=C(NC(=O)NC2=CC(C)=NC3=C(F)C=C(F)C=C23)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.64 100

Preparing Stock Solutions

The following data is based on the product molecular weight 356.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.81 mL 14.03 mL 28.06 mL
5 mM 0.56 mL 2.81 mL 5.61 mL
10 mM 0.28 mL 1.4 mL 2.81 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Langmead et al (2004) Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. Br.J.Pharmacol. 141 340 PMID: 14691055

Porter (2001) Advances in novel 7-TM receptors: non-peptide orexin-1 antagonists. Royal Society of Chemistry Meeting. PMID:


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Keywords: SB 408124, supplier, Selective, non-peptide, OX1, antagonists, Orexin1, Receptors, SB408124, GlaxoSmithKline, GSK, OX1, Receptor, Tocris Bioscience

1 Citation for SB 408124

Citations are publications that use Tocris products. Selected citations for SB 408124 include:

UrbaƂska et al (2012) Orexins/hypocretins acting at Gi protein-coupled OX 2 receptors inhibit cyclic AMP synthesis in the primary neuronal cultures. BMC Cancer 46 42561 PMID: 21547533


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