SSR 146977 hydrochloride

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Description: Potent and selective NK3 antagonist
Chemical Name: N1-[1-3-[(3R)-1-Benzoyl-3-(3-(3,4-dichlorophenyl)-3-piperidinyl]propyl]-4-phenyl-piperidinyl]-N,N-dimethylurea hydrochloride
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for SSR 146977 hydrochloride

SSR 146977 hydrochloride is a potent and selective NK3 receptor antagonist (Ki values are 0.26 and 19.3 nM in CHO cells expressing the human NK3 and NK2 receptor respectively). Also inhibits senktide-induced inositol monophosphate formation and intracellular calcium mobilization (IC50 = 10 nM).

Compound Libraries for SSR 146977 hydrochloride

SSR 146977 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SSR 146977 hydrochloride

M. Wt 658.11
Formula C35H42Cl2N4O2.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 264618-38-4
PubChem ID 90488827
Smiles O=C(N(C)C)NC1(C4=CC=CC=C4)CCN(CCC[C@]3(CN(C(C5=CC=CC=C5)=O)CCC3)[C@]2=CC=C(Cl)C(Cl)=C2)CC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SSR 146977 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 65.81 100
ethanol 65.81 100

Preparing Stock Solutions for SSR 146977 hydrochloride

The following data is based on the product molecular weight 658.11. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.52 mL 7.6 mL 15.2 mL
5 mM 0.3 mL 1.52 mL 3.04 mL
10 mM 0.15 mL 0.76 mL 1.52 mL
50 mM 0.03 mL 0.15 mL 0.3 mL

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Product Datasheets for SSR 146977 hydrochloride

References for SSR 146977 hydrochloride

References are publications that support the biological activity of the product.

Emonds-Alt et al (2002) Biochemical and pharmacological activities of SSR 146977, a new potent nonpeptide tachykinin NK3 receptor antagonist. Can.J.Physiol.Pharmacol. 80 482 PMID: 12056557

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Citations for SSR 146977 hydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.