SSR 146977 hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 3297 - SSR 146977 hydrochloride | C35H42Cl2N4O2.HCl | CAS No. 264618-38-4
Description: Potent and selective NK3 antagonist
Chemical Name: N1-[1-3-[(3R)-1-Benzoyl-3-(3-(3,4-dichlorophenyl)-3-piperidinyl]propyl]-4-phenyl-piperidinyl]-N,N-dimethylurea hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective NK3 receptor antagonist (Ki values are 0.26 and 19.3 nM in CHO cells expressing the human NK3 and NK2 receptor respectively). Also inhibits senktide-induced inositol monophosphate formation and intracellular calcium mobilization (IC50 = 10 nM).

Technical Data

M. Wt 658.11
Formula C35H42Cl2N4O2.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 264618-38-4
PubChem ID 90488827
InChI Key HYPKKQPFHSNZBY-GXUZKUJRSA-N
Smiles O=C(N(C)C)NC1(C4=CC=CC=C4)CCN(CCC[C@]3(CN(C(C5=CC=CC=C5)=O)CCC3)[C@]2=CC=C(Cl)C(Cl)=C2)CC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 65.81 100
ethanol 65.81 100

Preparing Stock Solutions

The following data is based on the product molecular weight 658.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.52 mL 7.6 mL 15.2 mL
5 mM 0.3 mL 1.52 mL 3.04 mL
10 mM 0.15 mL 0.76 mL 1.52 mL
50 mM 0.03 mL 0.15 mL 0.3 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Emonds-Alt et al (2002) Biochemical and pharmacological activities of SSR 146977, a new potent nonpeptide tachykinin NK3 receptor antagonist. Can.J.Physiol.Pharmacol. 80 482 PMID: 12056557


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Keywords: SSR 146977 hydrochloride, supplier, tachykinin, neurokinin, receptors, nk3, neuropeptides, antagonists, SSR146977, NK3, Receptor, NK3, Receptor, Tocris Bioscience

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