SSR 146977 hydrochloride

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Cat.No. 3297 - SSR 146977 hydrochloride | C35H42Cl2N4O2.HCl | CAS No. 264618-38-4
Description: Potent and selective NK3 antagonist
Chemical Name: N1-[1-3-[(3R)-1-Benzoyl-3-(3-(3,4-dichlorophenyl)-3-piperidinyl]propyl]-4-phenyl-piperidinyl]-N,N-dimethylurea hydrochloride
Purity: ≥98% (HPLC)
Literature (6)

Biological Activity

Potent and selective NK3 receptor antagonist (Ki values are 0.26 and 19.3 nM in CHO cells expressing the human NK3 and NK2 receptor respectively). Also inhibits senktide-induced inositol monophosphate formation and intracellular calcium mobilization (IC50 = 10 nM).

Compound Libraries

SSR 146977 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 658.11
Formula C35H42Cl2N4O2.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 264618-38-4
PubChem ID 90488827
Smiles O=C(N(C)C)NC1(C4=CC=CC=C4)CCN(CCC[C@]3(CN(C(C5=CC=CC=C5)=O)CCC3)[C@]2=CC=C(Cl)C(Cl)=C2)CC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 65.81 100
ethanol 65.81 100

Preparing Stock Solutions

The following data is based on the product molecular weight 658.11. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.52 mL 7.6 mL 15.2 mL
5 mM 0.3 mL 1.52 mL 3.04 mL
10 mM 0.15 mL 0.76 mL 1.52 mL
50 mM 0.03 mL 0.15 mL 0.3 mL

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References are publications that support the biological activity of the product.

Emonds-Alt et al (2002) Biochemical and pharmacological activities of SSR 146977, a new potent nonpeptide tachykinin NK3 receptor antagonist. Can.J.Physiol.Pharmacol. 80 482 PMID: 12056557

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