NADPH Oxidase

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases are multi-subunit enzyme complexes that transfer electrons across biological membranes and catalyze the production of reactive oxygen species (ROS).

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
4663 Apocynin
NADPH-oxidase inhibitor
0504 Diphenyleneiodonium chloride
Inhibits NADPH oxidases; also inhibits NOS
4653 ML 171
Selective NADPH oxidase 1 (NOX1) inhibitor
5848 NoxA1ds
Potent and selective NADPH oxidase 1 (NOX1) inhibitor

Other

Cat No Product Name / Activity
5515 NADPH reduced form tetrasodium salt
Cofactor for many anabolic enzymes

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases are multi-subunit enzyme complexes that transfer electrons across biological membranes and catalyze the production of reactive oxygen species (ROS). NADPH oxidases use NADPH as an electron donor in the reduction of molecular oxygen to form superoxide anion radicals. These enzymes have been found in virtually all tissues and have been shown to mediate a variety of responses, including cell growth and apoptosis, angiogenesis, innate immunity, regulation of the extracellular matrix, and thyroid hormone biosynthesis.

There are seven members of the NADPH oxidase family, all of which differ in their catalytic subunit and tissue distribution. NOX1 is found in colon and vascular cells which function in host defence and cell growth; NOX2 is present in phagocytes and involved in respiration; NOX3 is found in the inner ear; NOX4 is widely distributed and NOX5 is a calcium-dependent homolog mainly expressed in lymphoid tissues. Additional members of the NADPH oxidase family include the DUOX proteins, which were identified from the thyroid gland and contain a putative peroxidase domain. In addition to the thyroid gland, DUOX1 is also found in airway epithelia and the prostate whilst DUOX2 is expressed in the gastrointestinal tract.

ROS derived from NADPH oxidase enzymes are critical for normal physiological responses, but also contribute to a growing number of diseases, including atherosclerosis, hypertension, arthritis, Alzheimer's disease, cancer and respiratory syndromes.

Literature for NADPH Oxidase

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NADPH oxidase Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
NADPH oxidase 1 Human NOX1 NP_008983.2 Q9Y5S8
Mouse Nox1 NM_172203 NP_757340
Rat Nox1 NM_053683 NP_446135
Cytochrome b-245, beta polypeptide (NOX2) Human CYBB NM_000397 P04839
Mouse Cybb NM_007807 NP_031833
Rat Cybb NM_023965 NP_076455
NADPH oxidase 3 Human NOX3 NM_015718 Q9HBY0
Mouse Nox3 NM_198958 NM_198958
Rat Nox3 NM_001004216 NP_001004216
NADPH oxidase 4 Human NOX4 NM_016931.3 Q9NPH5
Mouse Nox4 NM_015760 NP_056575
Rat Nox4 NM_053524 NP_445976
NADPH oxidase, EF-hand calcium binding domain 5 Human NOX5 NM_024505.3 Q96PH1
Mouse - - -
Rat - - -
Dual oxidase 1 Human DUOX1 NM_017434.3 Q9NRD9
Mouse Duox1 NM_001099297 NP_001092767
Rat Duox1 NM_153739 NP_714961
Dual oxidase 2 Human DUOX2 NM_006142 P31947
Mouse Duox2 NM_177610 NP_808278
Rat Duox2 NM_024141 NP_077055