VAS 2870

Pricing Availability   Qty
Description: NADPH oxidase (Nox) inhibitor
Chemical Name: 7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine
Purity: ≥98% (HPLC)
Citations (1)
Literature (1)

Biological Activity for VAS 2870

VAS 2870 is a NADPH oxidase (Nox) inhibitor. Inhibits PMA-stimulated oxidative burst in HL-60 cells (IC50 = 2 μM). Inhibits oxidized-LDL-mediated, but not basal, ROS production in HUVECs in vitro. Also inhibits PDGF-mediated Nox activation and ROS formation in vascular smooth muscle cells (VSMCs) and abolishes PDGF-dependent migration of VSMCs, while having no effect on proliferation. Enhances TGF-β-induced apoptosis of liver tumor cells. Also inhibits platelet aggregation through a NOX-independent mechanism.

Compound Libraries for VAS 2870

VAS 2870 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for VAS 2870

M. Wt 360.39
Formula C18H12N6OS
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 722456-31-7
PubChem ID 4058452
Smiles N1(N=NC2=C(N=CN=C12)SC3=NC4=CC=CC=C4O3)CC5=CC=CC=C5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for VAS 2870

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 36.04 100

Preparing Stock Solutions for VAS 2870

The following data is based on the product molecular weight 360.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.87 mL 27.75 mL
5 mM 0.55 mL 2.77 mL 5.55 mL
10 mM 0.28 mL 1.39 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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References for VAS 2870

References are publications that support the biological activity of the product.

Stielow et al (2006) Novel Nox inhibitor of oxLDL-induced reactive oxygen species formation in human endothelial cells. Biochem.Biophys.Res.Commun. 344 200 PMID: 16603125

Sancho and Fabregat et al (2011) The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells. Biochem.Pharmacol. 81 917 PMID: 21276422

ten Freyhaus et al (2006) Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation. Cardiovasc.Res. 71 331 PMID: 16545786

Lu et al (2019) VAS2870 and VAS3947 attenuate platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC Sci.Rep. 9 18852 PMID: 31827142

If you know of a relevant reference for VAS 2870, please let us know.

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Keywords: VAS 2870, VAS 2870 supplier, VAS2870, NADPH, oxidase, inhibitors, inhibits, nicotinamide, adenine, dinucleotide, phosphate, NOX, reactive, oxygen, species, ROS, Oxidase, 6654, Tocris Bioscience

1 Citation for VAS 2870

Citations are publications that use Tocris products. Selected citations for VAS 2870 include:

Qiang et al (2021) Placenta-derived IL-32β activates neutrophils to promote preeclampsia development. Cell Mol Immunol 18 979-991 PMID: 33707686

Do you know of a great paper that uses VAS 2870 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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