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Description: NADPH-oxidase inhibitor
Chemical Name: 4'-Hydroxy-3'-methoxyacetophenone
Purity: ≥99% (HPLC)
Citations (11)
Reviews (1)
Literature (1)

Biological Activity for Apocynin

Apocynin is an NADPH oxidase inhibitor. Demonstrates anti-inflammatory properties in a mouse model of carrageenan-induced pleurisy. Apocynin is bioactivated by intracellular peroxidases; acts as an antioxidant in endothelial cells and vascular smooth muscle cells.

Compound Libraries for Apocynin

Apocynin is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Apocynin

M. Wt 166.17
Formula C9H10O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 498-02-2
PubChem ID 2214
Smiles CC(C1=CC(OC)=C(O)C=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Apocynin

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 16.62 100
ethanol 16.62 100

Preparing Stock Solutions for Apocynin

The following data is based on the product molecular weight 166.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.02 mL 30.09 mL 60.18 mL
5 mM 1.2 mL 6.02 mL 12.04 mL
10 mM 0.6 mL 3.01 mL 6.02 mL
50 mM 0.12 mL 0.6 mL 1.2 mL

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References for Apocynin

References are publications that support the biological activity of the product.

Stolk et al (1994) Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol. Am.J.Respir.Cell Mol.Biol. 11 95 PMID: 8018341

Impellizzeri et al (2011) Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation. Biochem.Pharmacol. 81 636 PMID: 21147071

Heumüller et al (2008) Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension 51 211 PMID: 18086956

If you know of a relevant reference for Apocynin, please let us know.

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Keywords: Apocynin, Apocynin supplier, Apocynin, NADPH, oxidases, inhibitors, inhibits, leukocytes, anti-inflammatory, peroxidases, Oxidase, 4663, Tocris Bioscience

11 Citations for Apocynin

Citations are publications that use Tocris products. Selected citations for Apocynin include:

Kyung-Sun et al (2022) Ginsenoside Rh1 Inhibits Angiotensin II-Induced Vascular Smooth Muscle Cell Migration and Proliferation through Suppression of the ROS-Mediated ERK1/2/p90RSK/KLF4 Signaling Pathway. Antioxidants (Basel) 11 PMID: 35453328

Chiao et al (2022) Interleukin-1 receptor antagonism leads to improved anaemia in a murine model of sickle cell disease and is associated with reduced ex vivo platelet-mediated erythrocyte sickling. Br J Haematol 196 1040-1051 PMID: 34786709

Minsoo et al (2019) Microglia-Triggered Plasticity of Intrinsic Excitability Modulates Psychomotor Behaviors in Acute Cerebellar Inflammation. Cell Rep 28 2923-2938.e8 PMID: 31509752

Rebecca L et al (2019) NADPH Oxidase Mediates Membrane Androgen Receptor-Induced Neurodegeneration. Endocrinology 160 947-963 PMID: 30811529

Do you know of a great paper that uses Apocynin from Tocris? Please let us know.

Reviews for Apocynin

Average Rating: 5 (Based on 1 Review.)

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By Anonymous on 01/10/2018
Assay Type: Ex Vivo
Species: Rat
Cell Line/Tissue: brain slice

Apocynin is a NADPH oxidase inhibitor. It blocks NADPH oxidase in rat brain slice at 1mM.

Literature in this Area

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