NADPH oxidase inhibitor. Demonstrates anti-inflammatory properties in a mouse model of carrageenan-induced pleurisy. Bioactivated by intracellular peroxidases; acts as an antioxidant in endothelial cells and vascular smooth muscle cells.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 166.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||6.02 mL||30.09 mL||60.18 mL|
|5 mM||1.2 mL||6.02 mL||12.04 mL|
|10 mM||0.6 mL||3.01 mL||6.02 mL|
|50 mM||0.12 mL||0.6 mL||1.2 mL|
References are publications that support the biological activity of the product.
Stolk et al (1994) Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol. Am.J.Respir.Cell Mol.Biol. 11 95 PMID: 8018341
Impellizzeri et al (2011) Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation. Biochem.Pharmacol. 81 636 PMID: 21147071
Heumüller et al (2008) Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension 51 211 PMID: 18086956
If you know of a relevant reference for Apocynin, please let us know.
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Keywords: Apocynin, Apocynin supplier, Apocynin, NADPH, oxidases, inhibitors, inhibits, leukocytes, anti-inflammatory, peroxidases, Oxidase, 4663, Tocris Bioscience
2 Citations for Apocynin
Citations are publications that use Tocris products. Selected citations for Apocynin include:
Hassler et al (2014) Reactive oxygen species and lipid peroxidation inhibitors reduce mechanical sensitivity in a chronic neuropathic pain model of spinal cord injury in rats. Int J Mol Med 131 413 PMID: 25051888
Walsh et al (2014) The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation. Redox Biol 2 178 PMID: 24494191
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Apocynin is a NADPH oxidase inhibitor. It blocks NADPH oxidase in rat brain slice at 1mM.
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