Apocynin

Pricing Availability Delivery Time Qty
Cat.No. 4663 - Apocynin | C9H10O3 | CAS No. 498-02-2
Description: NADPH-oxidase inhibitor
Chemical Name: 4'-Hydroxy-3'-methoxyacetophenone
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

NADPH oxidase inhibitor. Demonstrates anti-inflammatory properties in a mouse model of carrageenan-induced pleurisy. Bioactivated by intracellular peroxidases; acts as an antioxidant in endothelial cells and vascular smooth muscle cells.

Technical Data

M. Wt 166.17
Formula C9H10O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 498-02-2
PubChem ID 2214
InChI Key DFYRUELUNQRZTB-UHFFFAOYSA-N
Smiles CC(C1=CC(OC)=C(O)C=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.62 100
ethanol 16.62 100

Preparing Stock Solutions

The following data is based on the product molecular weight 166.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.02 mL 30.09 mL 60.18 mL
5 mM 1.2 mL 6.02 mL 12.04 mL
10 mM 0.6 mL 3.01 mL 6.02 mL
50 mM 0.12 mL 0.6 mL 1.2 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Stolk et al (1994) Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol. Am.J.Respir.Cell Mol.Biol. 11 95 PMID: 8018341

Impellizzeri et al (2011) Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation. Biochem.Pharmacol. 81 636 PMID: 21147071

Heumüller et al (2008) Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension 51 211 PMID: 18086956


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Keywords: Apocynin NADPH oxidases inhibitors inhibits leukocytes anti-inflammatory peroxidases NADPH Oxidase

2 Citations for Apocynin

Citations are publications that use Tocris products. Selected citations for Apocynin include:

Walsh et al (2014) The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation. Redox Biol 2 178 PMID: 24494191

Hassler et al (2014) Reactive oxygen species and lipid peroxidation inhibitors reduce mechanical sensitivity in a chronic neuropathic pain model of spinal cord injury in rats. Int J Mol Med 131 413 PMID: 25051888


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