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Biological Activity for Apocynin
Apocynin is an NADPH oxidase inhibitor. Demonstrates anti-inflammatory properties in a mouse model of carrageenan-induced pleurisy. Apocynin is bioactivated by intracellular peroxidases; acts as an antioxidant in endothelial cells and vascular smooth muscle cells.
Compound Libraries for Apocynin
Technical Data for Apocynin
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Apocynin
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Apocynin
The following data is based on the product molecular weight 166.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||6.02 mL||30.09 mL||60.18 mL|
|5 mM||1.2 mL||6.02 mL||12.04 mL|
|10 mM||0.6 mL||3.01 mL||6.02 mL|
|50 mM||0.12 mL||0.6 mL||1.2 mL|
References for Apocynin
References are publications that support the biological activity of the product.
Stolk et al (1994) Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol. Am.J.Respir.Cell Mol.Biol. 11 95 PMID: 8018341
Impellizzeri et al (2011) Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation. Biochem.Pharmacol. 81 636 PMID: 21147071
Heumüller et al (2008) Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension 51 211 PMID: 18086956
If you know of a relevant reference for Apocynin, please let us know.
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Keywords: Apocynin, Apocynin supplier, Apocynin, NADPH, oxidases, inhibitors, inhibits, leukocytes, anti-inflammatory, peroxidases, Oxidase, 4663, Tocris Bioscience
3 Citations for Apocynin
Citations are publications that use Tocris products. Selected citations for Apocynin include:
Walsh et al (2014) The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation. Redox Biol 2 178 PMID: 24494191
Michaeli et al (2017) Tumor-associated neutrophils induce apoptosis of non-activated CD8 T-cells in a TNFα and NO-dependent mechanism, promoting a tumor-supportive environment. Oncoimmunology 6 e1356965 PMID: 29147615
Hassler et al (2014) Reactive oxygen species and lipid peroxidation inhibitors reduce mechanical sensitivity in a chronic neuropathic pain model of spinal cord injury in rats. Int J Mol Med 131 413 PMID: 25051888
Do you know of a great paper that uses Apocynin from Tocris? Please let us know.
Reviews for Apocynin
Average Rating: 5 (Based on 1 Review.)
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Apocynin is a NADPH oxidase inhibitor. It blocks NADPH oxidase in rat brain slice at 1mM.
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