Hydroxycarboxylic Acid Receptors

Hydroxycarboxylic acid (HCA) receptors are Gi/Go protein-coupled receptors for which hydroxycarboxylic acids are endogenous ligands. Three HCA receptors are known to exist: HCA1 (GPR81), HCA2 (GPR109A) and HCA3 (GPR109B).

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
1762 Acifran
Hypolipidemic agent; agonist for the GPR109A (HM74A) and GPR109B receptors
4599 3,5-DHBA
Selective HCA1 agonist
2469 IBC 293
Selective agonist for the GPR109B (HM74) receptor. Antilipolytic
4881 LUF 6283
HCA2 (GPR109A) partial agonist
4622 MK 1903
Potent and selective GPR109A (HCA2) agonist
4511 MMF
Activator of Nrf2 pathway; GPR109A agonist

Hydroxycarboxylic acid (HCA) receptors, previously known as nicotinic acid receptors, are Gi/Go protein-coupled receptors for which hydroxycarboxylic acids are endogenous ligands. Three HCA receptors are known to exist: HCA1 (GPR81), HCA2 (GPR109A) and HCA3 (GPR109B).

GPR109B receptors originated from a gene duplication of GPR109A and have >95% homology. All subtypes are widely expressed throughout adipose tissue and are found at lower levels in macrophages, neutrophils, Langerhans cells and in the spleen. The human genes encoding these receptors are located on chromosome 12 (12q24.3).

External sources of pharmacological information for Hydroxycarboxylic Acid Receptors :

Literature for Hydroxycarboxylic Acid Receptors

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling

Hydroxycarboxylic Acid Receptor Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
GPR81 Human GPR81 NM_032554 Q9BXC0
Mouse Gpr81 NM_175520 Q8C131
Rat Gpr81 XM_001079195 XP_001072594
GPR109A Human NIACR1 NM_177551 Q8TDS4
Mouse Niacr1 NM_030701 Q9EP66
Rat Niacr1 NM_181476 Q80Z39
GPR109B Human NIACR2 NM_006018 P49019