Hypolipidemic agent. Exhibits higher potency than nicotinic acid and clofibrate. Full and potent agonist at the human orphan GPCR HM74A/GPR109A and GPR109B (EC50 values are 1.3 and 4.2 μM respectively). Reduces serum triglycerides and circulating LDL-cholesterol in vivo, without affecting liver weight or liver enzymes.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 218.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.58 mL||22.91 mL||45.83 mL|
|5 mM||0.92 mL||4.58 mL||9.17 mL|
|10 mM||0.46 mL||2.29 mL||4.58 mL|
|50 mM||0.09 mL||0.46 mL||0.92 mL|
References are publications that support the biological activity of the product.
Cayen et al (1982) Evaluation of the lipid-lowering activity of AY-25,712 in rats. Atherosclerosis 45 267 PMID: 6818976
Jirkovsky and Cayen (1982) Hypolipidemic 4,5-dihydro-4-oxo-5,5-disubstituted-2-furancarboxylic acids. J.Med.Chem. 25 1154 PMID: 7143351
Jung et al (2007) Analogues of acrifan: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b. J.Med.Chem. 50 1445 PMID: 17358052
Wise et al (2003) Molecular identification of high and low affinity receptors for nicotinic acid. J.Biol.Chem. 278 9869 PMID: 12522134
If you know of a relevant reference for Acifran, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Acifran, Acifran supplier, Hypolipidemic, agent, agonists, GPR109A, HM74A, GPR109B, receptors, HM74, nicotinic, acid, AY25712, AY, 25712, Hydroxycarboxylic, Acid, Receptors, 1762, Tocris Bioscience
Citations for Acifran
Citations are publications that use Tocris products.
Currently there are no citations for Acifran. Do you know of a great paper that uses Acifran from Tocris? Please let us know.
Reviews for Acifran
There are currently no reviews for this product. Be the first to review Acifran and earn rewards!
Have you used Acifran?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.