Acifran

Pricing Availability Delivery Time Qty
Cat.No. 1762 - Acifran | C12H10O4 | CAS No. 72420-38-3
Description: Hypolipidemic agent; agonist for the GPR109A (HM74A) and GPR109B receptors
Alternative Names: AY 25712
Chemical Name: 4,5-Dihydro-5-methyl-4-oxo-5-phenyl-2-furancarboxylic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Hypolipidemic agent. Exhibits higher potency than nicotinic acid and clofibrate. Full and potent agonist at the human orphan GPCR HM74A/GPR109A and GPR109B (EC50 values are 1.3¬†and 4.2 μM respectively). Reduces serum triglycerides and circulating LDL-cholesterol in vivo, without affecting liver weight or liver enzymes.

Compound Libraries

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Technical Data

M. Wt 218.21
Formula C12H10O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 72420-38-3
PubChem ID 51576
InChI Key DFDGRKNOFOJBAJ-UHFFFAOYSA-N
Smiles CC1(OC(=CC1=O)C(O)=O)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.82 100
ethanol 21.82 100

Preparing Stock Solutions

The following data is based on the product molecular weight 218.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.58 mL 22.91 mL 45.83 mL
5 mM 0.92 mL 4.58 mL 9.17 mL
10 mM 0.46 mL 2.29 mL 4.58 mL
50 mM 0.09 mL 0.46 mL 0.92 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Cayen et al (1982) Evaluation of the lipid-lowering activity of AY-25,712 in rats. Atherosclerosis 45 267 PMID: 6818976

Jirkovsky and Cayen (1982) Hypolipidemic 4,5-dihydro-4-oxo-5,5-disubstituted-2-furancarboxylic acids. J.Med.Chem. 25 1154 PMID: 7143351

Jung et al (2007) Analogues of acrifan: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b. J.Med.Chem. 50 1445 PMID: 17358052

Wise et al (2003) Molecular identification of high and low affinity receptors for nicotinic acid. J.Biol.Chem. 278 9869 PMID: 12522134


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Keywords: Acifran, supplier, Hypolipidemic, agent, agonists, GPR109A, HM74A, GPR109B, receptors, HM74, nicotinic, acid, AY25712, AY, 25712, Hydroxycarboxylic, Acid, Receptors, Tocris Bioscience

Citations for Acifran

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Literature in this Area

GPCR

GPCR Product Listing

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