Potent and selective hydroxycarboxylic acid receptor 2 (HCA2, GPR109A) full agonist; exhibits greater potency than niacin in a whole cell HTRF-cAMP assay (EC50 values are 12.9 and 51 nM respectively). Exhibits no binding at the GRP109B receptor.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 164.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||6.09 mL||30.46 mL||60.92 mL|
|5 mM||1.22 mL||6.09 mL||12.18 mL|
|10 mM||0.61 mL||3.05 mL||6.09 mL|
|50 mM||0.12 mL||0.61 mL||1.22 mL|
References are publications that support the products' biological activity.
Boatman (2012) (1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[α]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans. J.Med.Chem. 55 3644 PMID: 22435740
Lauring (2012) Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression. Sci.Transl.Med. 4 148ra115 PMID: 22914621
If you know of a relevant reference for MK 1903, please let us know.
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Keywords: MK 1903, supplier, MK1903, HCA2, hydroxycarboxylic, acid, receptors, GPR109A, HM74A, agonists, Hydroxycarboxylic, Acid, Receptors, Hydroxycarboxylic, Acid, Receptors, Tocris Bioscience
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