3,5-DHBA

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Cat.No. 4599 - 3,5-DHBA | C7H6O4 | CAS No. 99-10-5
Description: Selective HCA1 agonist
Chemical Name: 3,5-Dihydroxybenzoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective agonist of hydroxycarboxylic acid receptor 1 (HCA1, also known as GPR81) (EC50 ~150 μM). Inhibits lipolysis in wild-type mouse adipocytes. Displays minimal activity at HCA2 (at concentrations >10 mM) and no activity at HCA3, free fatty acid receptor (FFAR) 2 or FFAR3.

Technical Data

M. Wt 154.12
Formula C7H6O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 99-10-5
PubChem ID 7424
InChI Key UYEMGAFJOZZIFP-UHFFFAOYSA-N
Smiles OC1=CC(O)=CC(C(O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 15.41 100
ethanol 15.41 100
water 15.41 100

Preparing Stock Solutions

The following data is based on the product molecular weight 154.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.49 mL 32.44 mL 64.88 mL
5 mM 1.3 mL 6.49 mL 12.98 mL
10 mM 0.65 mL 3.24 mL 6.49 mL
50 mM 0.13 mL 0.65 mL 1.3 mL

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References

References are publications that support the products' biological activity.

Liu et al (2012) 3,5-dihydroxybenzoic acid, a specific agonist for hydroxycarboxylic acid 1, inhibits lipolysis in adipocytes. J.Pharmacol.Exp.Ther. 341 794 PMID: 22434674


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Keywords: gpr81 orphan receptors hca1 hydroxycarboxylic acid receptor 1 hca1 selective agonists Hydroxycarboxylic Acid Receptors

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GPCR

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Pathways for 3,5-DHBA

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