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Description: Selective HCA1 agonist
Chemical Name: 3,5-Dihydroxybenzoic acid
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity for 3,5-DHBA

3,5-DHBA is a selective agonist of hydroxycarboxylic acid receptor 1 (HCA1, also known as GPR81) (EC50 ~150 μM). Inhibits lipolysis in wild-type mouse adipocytes. Displays minimal activity at HCA2 (at concentrations >10 mM) and no activity at HCA3, free fatty acid receptor (FFAR) 2 or FFAR3.

Technical Data for 3,5-DHBA

M. Wt 154.12
Formula C7H6O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 99-10-5
PubChem ID 7424
Smiles OC1=CC(O)=CC(C(O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 3,5-DHBA

Solvent Max Conc. mg/mL Max Conc. mM
water 15.41 100
DMSO 15.41 100

Preparing Stock Solutions for 3,5-DHBA

The following data is based on the product molecular weight 154.12. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.49 mL 32.44 mL 64.88 mL
5 mM 1.3 mL 6.49 mL 12.98 mL
10 mM 0.65 mL 3.24 mL 6.49 mL
50 mM 0.13 mL 0.65 mL 1.3 mL

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References for 3,5-DHBA

References are publications that support the biological activity of the product.

Liu et al (2012) 3,5-dihydroxybenzoic acid, a specific agonist for hydroxycarboxylic acid 1, inhibits lipolysis in adipocytes. J.Pharmacol.Exp.Ther. 341 794 PMID: 22434674

If you know of a relevant reference for 3,5-DHBA, please let us know.

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Keywords: 3,5-DHBA, 3,5-DHBA supplier, gpr81, orphan, receptors, hca1, hydroxycarboxylic, acid, receptor, 1, selective, agonists, Hydroxycarboxylic, Acid, Receptors, 4599, Tocris Bioscience

1 Citation for 3,5-DHBA

Citations are publications that use Tocris products. Selected citations for 3,5-DHBA include:

Taesik et al (2020) Hydrocarboxylic acid receptor 1 in BAT regulates glucose uptake in mice fed a high-fat diet. PLoS One 15 e0228320 PMID: 31999787

Do you know of a great paper that uses 3,5-DHBA from Tocris? Please let us know.

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