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3,5-DHBA is a selective agonist of hydroxycarboxylic acid receptor 1 (HCA1, also known as GPR81) (EC50 ~150 μM). Inhibits lipolysis in wild-type mouse adipocytes. Displays minimal activity at HCA2 (at concentrations >10 mM) and no activity at HCA3, free fatty acid receptor (FFAR) 2 or FFAR3.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 154.12. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||6.49 mL||32.44 mL||64.88 mL|
|5 mM||1.3 mL||6.49 mL||12.98 mL|
|10 mM||0.65 mL||3.24 mL||6.49 mL|
|50 mM||0.13 mL||0.65 mL||1.3 mL|
References are publications that support the biological activity of the product.
Liu et al (2012) 3,5-dihydroxybenzoic acid, a specific agonist for hydroxycarboxylic acid 1, inhibits lipolysis in adipocytes. J.Pharmacol.Exp.Ther. 341 794 PMID: 22434674
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Keywords: 3,5-DHBA, 3,5-DHBA supplier, gpr81, orphan, receptors, hca1, hydroxycarboxylic, acid, receptor, 1, selective, agonists, Hydroxycarboxylic, Acid, Receptors, 4599, Tocris Bioscience
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