3,5-DHBA

Pricing Availability   Qty
Cat.No. 4599 - 3,5-DHBA | C7H6O4 | CAS No. 99-10-5
Description: Selective HCA1 agonist
Chemical Name: 3,5-Dihydroxybenzoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective agonist of hydroxycarboxylic acid receptor 1 (HCA1, also known as GPR81) (EC50 ~150 μM). Inhibits lipolysis in wild-type mouse adipocytes. Displays minimal activity at HCA2 (at concentrations >10 mM) and no activity at HCA3, free fatty acid receptor (FFAR) 2 or FFAR3.

Technical Data

M. Wt 154.12
Formula C7H6O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 99-10-5
PubChem ID 7424
InChI Key UYEMGAFJOZZIFP-UHFFFAOYSA-N
Smiles OC1=CC(O)=CC(C(O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 15.41 100
DMSO 15.41 100

Preparing Stock Solutions

The following data is based on the product molecular weight 154.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.49 mL 32.44 mL 64.88 mL
5 mM 1.3 mL 6.49 mL 12.98 mL
10 mM 0.65 mL 3.24 mL 6.49 mL
50 mM 0.13 mL 0.65 mL 1.3 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Liu et al (2012) 3,5-dihydroxybenzoic acid, a specific agonist for hydroxycarboxylic acid 1, inhibits lipolysis in adipocytes. J.Pharmacol.Exp.Ther. 341 794 PMID: 22434674


If you know of a relevant reference for 3,5-DHBA, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Hydroxycarboxylic Acid Receptor Agonists

Keywords: 3,5-DHBA, 3,5-DHBA supplier, gpr81, orphan, receptors, hca1, hydroxycarboxylic, acid, receptor, 1, selective, agonists, Hydroxycarboxylic, Acid, Receptors, 4599, Tocris Bioscience

Citations for 3,5-DHBA

Citations are publications that use Tocris products.

Currently there are no citations for 3,5-DHBA. Do you know of a great paper that uses 3,5-DHBA from Tocris? Please let us know.

Reviews for 3,5-DHBA

There are currently no reviews for this product. Be the first to review 3,5-DHBA and earn rewards!

Have you used 3,5-DHBA?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling