ETB Receptors

The endothelinB receptor (ETB receptor) is a member of the endothelin receptor group of G-protein-coupled receptors that also includes ETA. They are located primarily in vascular endothelial cells where they play a role in vasoconstriction, vasodilation and cell proliferation.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
1189 BQ-3020
Selective ETB agonist
1197 [Ala1,3,11,15]-Endothelin
Selective ETB agonist
1196 IRL-1620
Highly selective ETB agonist
1175 Sarafotoxin S6c
Selective ETB agonist

Antagonists

Cat No Product Name / Activity
1500 BQ 788 sodium salt
Selective ETB antagonist
1838 IRL-2500
Potent ETB antagonist
1195 IRL-1038
ETB antagonist

The endothelinB receptor (ETB receptor) is a member of the endothelin receptor group of G-protein-coupled receptors that also includes ETA. They are located primarily in the vascular endothelial cells where they play a role in vasoconstriction, vasodilation, bronchoconstriction and cell proliferation. The human ETB receptor gene has been localized to chromosome 13 (13q22).

External sources of pharmacological information for ETB Receptors :

Literature for ETB Receptors

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Peptide Hormone Receptors

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing
Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

ETB Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human EDNRB NM_003991 P24530
Mouse EdnrB NM_007904 P48302
Rat EdnrB NM_017333 P21451