BQ-3020

Pricing Availability   Qty
Description: Selective ETB agonist
Purity: ≥95% (HPLC)
Datasheet
Citations (1)
Reviews

Biological Activity for BQ-3020

BQ-3020 is a highly potent and selective ETB endothelin receptor agonist (Ki values are 0.18 and 970 nM at human ETB and ETA receptors respectively).

Technical Data for BQ-3020

M. Wt 2006.35
Formula C96H140N20O25S
Sequence LMDKEAVYFAHLDIIW

(Modifications: Leu-1 = N-terminal Ac)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 143113-45-5
PubChem ID 16135850
InChI Key AYJUXFCWNAVJLN-FHOIYVHLSA-N
Smiles CC[C@H](C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(C)=O)C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BQ-3020

Solubility Soluble to 0.50 mg/ml in sodium bicarbonate (0.03M)

Product Datasheets for BQ-3020

Certificate of Analysis / Product Datasheet
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References for BQ-3020

References are publications that support the biological activity of the product.

Ekelund et al (1994) Effects of selective ETB-receptor stimulation on arterial, venous and capillary functions in cat skeletal muscle. Br.J.Pharmacol. 112 887 PMID: 7921617

Ihara et al (1995) [3H]-BQ-123, a highly specific and reversible radioligand for the endothelin ETA receptor subtype. Eur.J.Pharmacol. 274 1 PMID: 7768260

Reynolds et al (1995) Pharmacological differences between rat and human endothelin B receptors. Biochem.Biophys.Res.Commun. 209 506 PMID: 7733918

Sakamoto et al (1993) Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists. J.Biol.Chem. 268 8547 PMID: 8473300


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Keywords: BQ-3020, BQ-3020 supplier, Selective, ETB, agonists, Receptors, Endothelin, 1189, Tocris Bioscience

1 Citation for BQ-3020

Citations are publications that use Tocris products. Selected citations for BQ-3020 include:

Hamby et al (2012) Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. Cell Death Dis 32 14489 PMID: 23077035


Do you know of a great paper that uses BQ-3020 from Tocris? Please let us know.

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