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Biological Activity for BQ-3020
BQ-3020 is a highly potent and selective ETB endothelin receptor agonist (Ki values are 0.18 and 970 nM at human ETB and ETA receptors respectively).
Technical Data for BQ-3020
(Modifications: Leu-1 = N-terminal Ac)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BQ-3020
|Solubility||Soluble to 0.50 mg/ml in sodium bicarbonate (0.03M)|
References for BQ-3020
References are publications that support the biological activity of the product.
Ekelund et al (1994) Effects of selective ETB-receptor stimulation on arterial, venous and capillary functions in cat skeletal muscle. Br.J.Pharmacol. 112 887 PMID: 7921617
Ihara et al (1995) [3H]-BQ-123, a highly specific and reversible radioligand for the endothelin ETA receptor subtype. Eur.J.Pharmacol. 274 1 PMID: 7768260
Reynolds et al (1995) Pharmacological differences between rat and human endothelin B receptors. Biochem.Biophys.Res.Commun. 209 506 PMID: 7733918
Sakamoto et al (1993) Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists. J.Biol.Chem. 268 8547 PMID: 8473300
If you know of a relevant reference for BQ-3020, please let us know.
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Keywords: BQ-3020, BQ-3020 supplier, Selective, ETB, agonists, Receptors, Endothelin, 1189, Tocris Bioscience
1 Citation for BQ-3020
Citations are publications that use Tocris products. Selected citations for BQ-3020 include:
Hamby et al (2012) Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. Cell Death Dis 32 14489 PMID: 23077035
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Literature in this Area
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