The endothelinA receptor (ETA receptor) is a member of the endothelin receptor group of G-protein-coupled receptors that also includes ETB. They are located primarily in the vascular smooth muscle where they play a role in vasoconstriction and cell proliferation.
ETA Receptor Antagonists |
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Cat. No. | Product Name / Activity |
5730 | A 127722 |
Highly potent, selective ETA antagonist; orally bioavailable | |
5828 | Ambrisentan |
Selective ETA antagonist | |
1188 | BQ-123 |
Selective ETA antagonist | |
2942 | CI 1020 |
Highly selective, orally active ETA antagonist |
The endothelinA receptor (ETA receptor) is a member of the endothelin receptor group of G-protein-coupled receptors that also includes ETB. They are located primarily in the vascular smooth muscle where they play a role in vasoconstriction and cell proliferation. The human ETA receptor gene has been localized to chromosome 4 (4q31.22).
Tocris offers the following scientific literature for ETA Receptors to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.