BQ 788 sodium salt
Potent, selective ETB receptor antagonist (IC50 = 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells).
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 663.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.51 mL||7.53 mL||15.07 mL|
|5 mM||0.3 mL||1.51 mL||3.01 mL|
|10 mM||0.15 mL||0.75 mL||1.51 mL|
|50 mM||0.03 mL||0.15 mL||0.3 mL|
References are publications that support the products' biological activity.
Davenport (2002) International Union of Pharmacology. XXIX. Update on endothelin receptor nomenclature. Pharmacol.Rev. 54 219 PMID: 12037137
Ishikawa et al (1994) Biochemical and pharmacological profile of a potent and selective endothelin B-receptor antagonist, BQ-788. Proc.Natl.Acad.Sci.U.S.A. 91 4892 PMID: 8197152
Okada and Nishikibe (2002) BQ-788, a selective endothelin ETB receptor antagonist. Cardiovasc.Drug Rev. 20 53 PMID: 12070534
If you know of a relevant reference for BQ 788 sodium salt, please let us know.
View Related Products by Product Action
Keywords: BQ 788 sodium salt, supplier, Selective, ETB, antagonists, Receptors, Endothelin, BQ788, sodium, salt, Endothelin, ETB, Receptors, Endothelin, ETB, Receptors, Tocris Bioscience
6 Citations for BQ 788 sodium salt
Citations are publications that use Tocris products. Selected citations for BQ 788 sodium salt include:
Allahdadi et al (2010) Endothelin-1 induces contraction of female rat internal pudendal and clitoral arteries through ET(A) receptor and rho-kinase activation. PLoS One 7 2096 PMID: 20412427
Sánchez et al (2014) Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from insulin-resistant obese rats: role of ET(A) and ET(B) receptors. Br J Pharmacol 171 5682 PMID: 25091502
Yeligar et al (2009) Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199. J Immunol 183 5232 PMID: 19783678
Patel et al (2014) Activation of the endothelin system mediates pathological angiogenesis during ischemic retinopathy. J Sex Med 184 3040 PMID: 25203536
McQueen et al (2007) Endothelin-1 activates ETA receptors to cause reflex scratching in BALB/c mice. Br J Pharmacol 151 278 PMID: 17351652
Durgan et al (2015) Increased cerebrovascular sensitivity to endothelin-1 in a rat model of obstructive sleep apnea: a role for endothelin receptor B. J Cereb Blood Flow Metab 35 402 PMID: 25425077
Do you know of a great paper that uses BQ 788 sodium salt from Tocris? If so please let us know.
Reviews for BQ 788 sodium salt
Average Rating: 5 (Based on 1 Review)
Have you used BQ 788 sodium salt?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review
We utilized this product at 1uM to inhibit endothelin-B receptors ex vivo in mouse aortas followed by vasomotor function experiments. We have obtained superior results using this BQ788 product!
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.