You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for Ambrisentan
Ambrisentan is a selective endothelin receptor ETA antagonist. Displays approximately 200-fold selectivity for ETA over ETB (Ki values are 1 nM and 195 nM for respectively). Prevents endothelin-induced sudden death in rats.
Compound Libraries for Ambrisentan
Technical Data for Ambrisentan
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ambrisentan
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Ambrisentan
The following data is based on the product molecular weight 378.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.64 mL||13.21 mL||26.43 mL|
|5 mM||0.53 mL||2.64 mL||5.29 mL|
|10 mM||0.26 mL||1.32 mL||2.64 mL|
|50 mM||0.05 mL||0.26 mL||0.53 mL|
References for Ambrisentan
References are publications that support the biological activity of the product.
Riechers et al (1996) Discovery and optimization of a novel class of orally active nonpeptidic endothelin-A receptor antagonists. J.Med.Chem. 39 2123 PMID: 8667356
Vatter & Seifert (2006) Ambrisentan, a non-peptide endothelin receptor antagonist. Cardiovasc.Drug Rev. 24 63 PMID: 16939634
If you know of a relevant reference for Ambrisentan, please let us know.
View Related Products by Product Action
Keywords: Ambrisentan, Ambrisentan supplier, endothelin, ETA, receptor, antagonists, inhibits, antagonism, selective, Endothelin, Receptors, 5828, Tocris Bioscience
Citations for Ambrisentan
Citations are publications that use Tocris products.
Currently there are no citations for Ambrisentan. Do you know of a great paper that uses Ambrisentan from Tocris? Please let us know.
Reviews for Ambrisentan
There are currently no reviews for this product. Be the first to review Ambrisentan and earn rewards!
Have you used Ambrisentan?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.