BQ-123

Pricing Availability   Qty
Cat.No. 1188 - BQ-123 | cyclo(D-Trp-D-Asp-Pro-D-Val-Leu) | CAS No. 136553-81-6
Description: Selective ETA antagonist
Datasheet
Citations (7)
Reviews (1)
Literature (5)

Biological Activity

Selective ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively). Reduces ischemia-induced ventricular arrhythmias in a rat model.

Technical Data

M. Wt 611
Formula C31H42N6O7
Sequence WDPVL

(Modifications: Trp-1 = D-Trp, Val-4 = D-Val, Cyclized)

Storage Desiccate at -20°C
CAS Number 136553-81-6
PubChem ID 52943236
InChI Key VYCMAAOURFJIHD-AOYLRGCGSA-N
Smiles CC(C)C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC1=O)C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 0.10 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Agapitov and Haynes (2002) Role of endothelin in cardiovascular disease. J.Renin Angiotensin Aldosterone Syst. 3 1 PMID: 11984741

Ekelund et al (1994) Effects of selective ETB-receptor stimulation on arterial, venous and capillary functions in cat skeletal muscle. Br.J.Pharmacol. 112 887 PMID: 7921617

Makatani et al (2000) Effect of a novel bifunctional endothelin receptor antagonist, IRL 3630A, on guinea pig respiratory mechanics. Eur.J.Pharmacol. 406 139 PMID: 11011045

Sakamoto et al (1993) Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists. J.Biol.Chem. 268 8547 PMID: 8473300


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Keywords: BQ-123, BQ-123 supplier, Selective, ETA, antagonists, Receptors, Endothelin, 1188, Tocris Bioscience

7 Citations for BQ-123

Citations are publications that use Tocris products. Selected citations for BQ-123 include:

Ou et al (2014) Adaptive regulation of endothelin receptor type-A and type-B in vascular smooth muscle cells during pregnancy in rats. J Cell Physiol 229 489 PMID: 24105843

Mazzuca et al (2013) Enhanced endothelin receptor type B-mediated vasodilation and underlying [Ca2+]i in mesenteric microvessels of pregnant rats. Br J Pharmacol 169 1335 PMID: 23646960

Craig and Martin (2012) Dominance of flow-mediated constriction over flow-mediated dilatation in the rat carotid artery. Br J Pharmacol 167 527 PMID: 22537086

Faraco et al (2014) Water deprivation induces neurovascular and cognitive dysfunction through vasopressin-induced oxidative stress. Am J Pathol 34 852 PMID: 24517977


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Reviews for BQ-123

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Great Product.
By Anonymous on 11/02/2017
Assay Type: Ex Vivo
Species: Mouse

We utilized this product at 1uM to inhibit endothelin-A receptors ex vivo in mouse aortas followed by conducting vasomotor function experiments. We utilized this ET-A inhibitor in combination with Tocris' BQ788 (endothelin-B receptor antagonist) which works equally as well. We have obtained high quality data using this BQ123 product!


Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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