Cytochrome P450

Cytochrome P450 (CYP450) enzymes are a diverse group of catalysts that contains 57 members in humans. CYPs are usually membrane-bound and are localized to the inner mitochondrial or endoplasmic reticular membrane. CYPs have oxygenase activity.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
5038 ABT
Cytochrome P450 inhibitor; inhibits 20-HETE synthesis
3388 Anastrozole
Potent aromatase (CYP19) inhibitor
6170 Cinacalcet hydrochloride
Potent CYP2D2 inhibitor; also CaSR allosteric agonist and Ca2+ channel blocker
4096 Clotrimazole
Cytochrome P450 inhibitor; antifungal
3759 Exemestane
Steroidal aromatase (CYP19) inhibitor
6108 Galeterone
CYP17 inhibitor; also androgen receptor antagonist
1103 Ketoconazole
Cytochrome P450c17 inhibitor
4382 Letrozole
Potent, reversible non-steroidal aromatase inhibitor
2705 Liarozole dihydrochloride
Cytochrome P450 (CYP26) inhibitor; blocks retinoic acid metabolism
3292 Metyrapone
Cytochrome P450 inhibitor
2583 Omeprazole
CYP2C19, CYP2C9 and CYP3A inhibitor. Also H+,K+-ATPase inhibitor
4252 PF 4981517
Selective CYP3A4 inhibitor
1509 TMS
Cytochrome P450 1B1 inhibitor
5680 Vatalanib succinate
Potent aromatase inhibitor; also VEGFR inhibitor
3278 YM 511
Potent aromatase (CYP19) inhibitor

Substrates

Cat No Product Name / Activity
4815 3-Cyano-7-ethoxycoumarin
Fluorescent cytochrome P450 substrate
6204 7-Ethoxyresorufin
Fluorometric CYP450 substrate
3276 Mephenytoin
CYP2C19 substrate. Anticonvulsant
4814 Methoxyresorufin
Fluorometric CYP450 substrate
4816 Pentoxyresorufin
Fluorometric cytochrome P450 substrate

Cytochrome P450 (CYP450) enzymes are a diverse group of catalysts that contains 57 members in humans. CYPs are usually membrane-bound and are localized to the inner mitochondrial or endoplasmic reticular membrane. CYPs have oxygenase activity and commonly catalyze redox reactions, involving the oxidation of the substrate and reduction of water. This group of enzymes contain a heme iron within the active site, which is essential for catalytic activity.

CYPs have been found in all organisms tested and are ubiquitously expressed. They are found at high levels in the liver, where they have an important role in metabolism of drugs and endogenous toxic compounds (for example bilirubin). Most CYPs can metabolize numerous substrates and this accounts for their major role in drug interactions. CYPs also have functions in steroid hormone synthesis, cholesterol synthesis and vitamin D metabolism.

Literature for Cytochrome P450

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Cytochrome P450 Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
CYP1A1 Human CYP1A1 NM_000499 P04798
Mouse Cyp1a1 NM_009992 P00184
Rat Cyp1a1 NM_012540 P00185
CYP1A2 Human CYP1A2 NM_000761 P05177
Mouse Cyp1a2 NM_009993 P00186
Rat Cyp1a2 NM_012541 P04799
CYP1B1 Human CYP1B1 NM_000104 Q16678
Mouse Cyp1b1 NM_009994 Q64429
Rat Cyp1b1 NM_012940 Q64678
CYP2A4 Mouse Cyp2a4 NM_009997 P15392
CYP2A5 Mouse Cyp2a5 NM_007812 P20852
CYP2A6 Human CYP2A6 NM_000762 Q9UK48
CYP2A7 Human CYP2A7 NM_030589 P20853
CYP2A13 Human CYP2A13 NM_000766 Q16696
CYP2A22 Mouse Cyp2a22 NM_001101467 NP_001094937
CYP2B6 Human CYP2B6 NM_000767 P20813
Rat Cyp2b6 M19973 AAA41048
CYP2B9 Mouse CYP2B9 NM_010000 P12790
CYP2B10 Mouse Cyp2b10 NM_009999 P12791
CYP2B13 Mouse Cyp2b13 NM_007813 NP_031839
Rat Cyp2b21 NM_198733 Q9JJ02
CYP2B19 Mouse Cyp2b19 NM_007814 O55071
CYP2C8 Human CYP2C8 NM_000770 P10632
CYP2C9 Human CYP2C9 NM_000771 P11712
CYP2C18 Human CYP2C18 NM_000772 P33260
CYP2C19 Human CYP2C19 NM_000769 P33261
CYP2C29 Mouse Cyp2c29 NM_007815 Q64458
CYP2C37 Mouse Cyp2c37 NM_010001 P56654
Rat Cyp2c37 XM_001063361 XP_001063361
CYP2C40 Mouse Cyp2c40 NM_010004 P56657
CYP2C55 Mouse Cyp2c55 NM_028089 Q9D816
CYP2D6 Human CYP2D6 NM_000106 P10635
Rat Cyp2d4v1 NM_138515 P13108
CYP2E1 Human CYP2E1 NM_000773 P05181
Mouse Cyp2e1 NM_021282 Q05421
Rat Cyp2e1 NM_031543 Q71UV8
CYP2F1 Human CYP2F1 NM_000774 P24903
CYP2F2 Mouse Cyp2f2 NM_007817 P33267
CYP2J2 Human CYP2J2 NM_000775 P51589
CYP2J6 Mouse Cyp2j6 NM_010008 O54750
CYP2R1 Human CYP2R1 NM_024514 Q6VVX0
Mouse Cyp2r1 NM_177382 Q6VVW9
Rat Cyp2r1 NM_001108499 XP_341910
CYP2S1 Human CYP2S1 NM_030622 Q96SQ9
Mouse Cyp2s1 NM_028775 Q9DBX6
Rat Cyp2s1 NM_001107495 Q66H37
CYP2U1 Human CYP2U1 NM_183075 Q7Z449
Mouse Cyp2u1 NM_027816 Q9CX98
Rat Cyp2u1 NM_001024779 Q4V8D1
CYP2W1 Human CYP2W1 NM_017781 Q8TAV3
Mouse Cyp2w1 XM_620268 XP_620268
Rat Cyp2w1 XM_221971 XP_221971
CYP3A4 Human CYP3A4 NM_017460 P08684
CYP3A5 Human CYP3A5 NM_000777 P20815
CYP3A7 Human CYP3A7 NM_000765 P24462
CYP3A11 Mouse Cyp3a11 NM_007818 Q64459
CYP3A13 Mouse Cyp3a13 NM_007819 Q64464
CYP3A16 Mouse Cyp3a16 NM_007820 Q64481
CYP3A25 Mouse Cyp3a25 NM_019792 O09158
CYP3A41a Mouse Cyp3a41a NM_017396 Q9JMA7
CYP3A41b Mouse Cyp3a41b NM_001105159 NP_001098629
CYP3A43 Human CYP3A43 NM_057096 Q9HB55
CYP3A44 Mouse Cyp3a44 NM_177380 NP_796354
CYP4A10 Mouse Cyp4a10 NM_010011 O88833
Rat Cyp4a10 NM_153307 NP_695219
CYP4A11 Human CYP4A11 NM_000778 Q02928
CYP4A22 Human CYP4A22 XM_208213 Q5TCH4
CYP4B1 Human CYP4B1 NM_000779 P13584
Mouse Cyp4b1 NM_007823 Q64462
Rat Cyp4b1 NM_016999 P15129
CYP4F2 Human CYP4F2 NM_001082 P78329
CYP4F3 Human CYP4F3 NM_000896 Q08477
CYP4F8 Human CYP4F8 NM_007253 P98187
CYP4F11 Human CYP4F11 NM_021187 Q9HBI6
CYP4F12 Human CYP4F12 NM_023944 Q9HCS2
CYP4F13 Mouse Cyp4f13 NM_130882 NP_570952
CYP4F14 Mouse Cyp4fr14 NM_022434 Q9EP75
CYP4F15 Mouse Cyp4fr15 NM_134127 NP_598888
CYP4F16 Mouse Cyp4fr16 NM_024442 NP_077762
CYP4F18 Mouse Cyp4f18 NM_024444 Q99N16
Rat Cyp4f18 NM_001033686 Q3MID2
CYP4F22 Human CYP4F22 NM_173483 Q6NT55
CYP4F39 Mouse Cyp4f39 NM_177307 NP_796281
Rat Cyp4f39 XM_234837 XP_234837
CYP4V2 Human CYP4V2 XM_209612 Q6ZWL3
CYP4V3 Mouse Cyp4v3 NM_133969 Q9DBW0
Rat Cyp4v3 NM_001135600 Q9EPX8
CYP4X1 Human CYP4X1 NM_178033 Q8N118
Mouse Cyp4x1 NM_001003947 NP_001003947
Rat Cyp4x1 NM_145675 Q8K4D6
CYP4Z1 Human CYP4Z1 NM_178134 Q86W10
CYP5A1 Human TBXAS1 NM_001061 Q9HD80
Mouse Tbxas1 NM_011539 P36423
CYP7A1 Human CYP7A1 NM_000780 P22680
Mouse Cyp7a1 NM_007824 Q64505
Rat Cyp7a1 NM_012942 P18125
CYP7B1 Human CYP7B1 NM_004820 O75881
Mouse Cyp7b1 NM_007825 Q60991
Rat Cyp7b1 NM_019138 Q63688
CYP8A1 Human PTGIS NM_000961 Q16647
Mouse Ptgis NM_008968 O35074
Rat Ptgis NM_031557 Q62969
CYP8B1 Human CYP8B1 NM_004391 Q9UNU6
Mouse Cyp8b1 NM_010012 O88962
Rat Cyp8b1 NM_031241 Q9WTN7
CYP11A1 Human CYP11A1 NM_000781 P05108
Mouse Cyp11a1 NM_019779 Q9QZ82
Rat Cyp11a1 NM_017286 P14137
CYP11B1 Human CYP11B1 NM_001026213 P15538
Mouse Cyp11b1 NM_001033229 NP_001028401
Rat Cyp11b1 NM_012537 P15393
CYP11B2 Human CYP11B2 NM_000498 P19099
Mouse Cyp11b2 NM_009991 P15539
Rat Cyp11b2 NM_012538 P30099
CYP17A1 Human CYP17A1 NM_000102 P05093
Mouse CYP17A1 NM_007809 P27786
Rat Cyp17a1 NM_012753 Q6LCX9
CYP19A1 Human CYP19A1 NM_031226 P11511
Mouse Cyp19a1 NM_007810 P28649
Rat Cyp19a1 NM_017085 P22443
CYP20A1 Human CYP20A1 NM_020674 Q6UW02
Mouse Cyp20a1 NM_030013 Q8BKE6
Rat Cyp20a1 NM_199401 Q6P7D4
CYP21A1 Mouse Cyp21a1 NM_009995 P03940
Rat Cyp21a1 NM_057101 Q8R402
CYP21A2 Human CYP21A2 NM_000500 P08686
CYP24A1 Human CYP24A1 NM_001128915 Q07973
Mouse Cyp24a1 NM_009996 Q64441
Rat Cyp24a1 NM_201635 Q09128
CYP26A1 Human CYP26A1 NM_057157 O43174
Mouse Cyp26a1 NM_007811 O55127
Rat Cyp26a1 NM_130408 Q304P5
CYP26B1 Human CYP26B1 NM_019885 Q9NR63
Mouse Cyp26b1 NM_175475 NP_780684
Rat Cyp26b1 NM_181087 Q80YE5
CYP26C1 Human Cyp26c1 NM_183374 Q6V0L0
Mouse Cyp26c1 NM_001105201 NP_001098671
Rat Cyp26c1 XM_217935 XP_217935
CYP27A1 Human CYP27A1 NM_000784 Q02318
Mouse Cyp27a1 NM_024264 Q9DBG1
Rat Cyp27a1 NM_178847 P17178
CYP27B1 Human CYP27B1 NM_000785 O15528
Mouse Cyp27b1 NM_010009 O35084
Rat Cyp27b1 NM_053763 O35132
CYP27C1 Human CYP27C1 NM_001001665 Q4G0S4
CYP39A1 Human CYP39A1 NM_016593 Q9NYL5
Mouse Cyp39a1 NM_018887 Q9JKJ9
Rat Cyp39a1 NM_001106893 XP_236983
CYP46A1 Human CYP46A1 NM_006668 Q9Y6A2
Mouse Cyp46a1 NM_010010 Q9WVK8
Rat Cyp46a1 NM_001108723 XP_343109
CYP51A1 Human CYP51A1 NM_000786 Q16850
Mouse Cyp51 NM_020010 NP_064394
Rat Cyp51 NM_012941 Q64654