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Biological Activity for Clotrimazole
Clotrimazole is an imidazole antimycotic and cytochrome P450 inhibitor. Inhibits Ca2+-activated K+ current (IC50 = 3 μM) and L-type Ca2+ current; increases the firing rate of action potentials. Exhibits antiproliferative activity in vitro and in vivo. Also an inverse agonist of the human constitutive androstane receptor (hCAR).
Compound Libraries for Clotrimazole
Technical Data for Clotrimazole
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Clotrimazole
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Clotrimazole
The following data is based on the product molecular weight 344.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.9 mL||14.5 mL||29 mL|
|5 mM||0.58 mL||2.9 mL||5.8 mL|
|10 mM||0.29 mL||1.45 mL||2.9 mL|
|50 mM||0.06 mL||0.29 mL||0.58 mL|
References for Clotrimazole
References are publications that support the biological activity of the product.
Snajdrova et al (1998) Clomitrazole, an antimycotic drug, inhibits the sarcoplasmic reticulum calcium pump and contractile function in heart muscle. J.Biol.Chem. 273 28032 PMID: 9774419
Wu et al (1999) Inhibition of Ca2+-activated K+ current by clotrimazole in rat anterior pituitary GH3 cells. Neuropharmacology 38 979 PMID: 10428416
Thomas et al (1999) The antifungal antibiotic clotrimazole potently inhibits L-type calcium current in guinea-pig ventricular myocytes. Br.J.Pharmacol. 126 1531 PMID: 10323582
Lempiainen et al (2005) Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with corepressor protein. Mol.Endocrinol. 19 2258 PMID: 15905360
If you know of a relevant reference for Clotrimazole, please let us know.
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3 Citations for Clotrimazole
Citations are publications that use Tocris products. Selected citations for Clotrimazole include:
Rossen et al (2021) Pseudomonas aeruginosa-induced nociceptor activation increases susceptibility to infection. PLoS Pathog 17 e1009557 PMID: 33956874
Anne-Amandine et al (2021) TREK channel activation suppresses migraine pain phenotype. iScience 24 102961 PMID: 34458705
Mark M et al (2021) Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition. Elife 10 PMID: 33856345
Do you know of a great paper that uses Clotrimazole from Tocris? Please let us know.
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