Clotrimazole

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Cat.No. 4096 - Clotrimazole | C22H17ClN2 | CAS No. 23593-75-1
Description: Cytochrome P450 inhibitor; antifungal
Alternative Names: CLT
Chemical Name: 1-(2-Chloro-α,α-diphenylbenzyl)imidazole
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Imidazole antimycotic and cytochrome P450 inhibitor. Inhibits Ca2+-activated K+ current (IC50 = 3 μM) and L-type Ca2+ current; increases the firing rate of action potentials. Exhibits antiproliferative activity in vitro and in vivo. Also an inverse agonist of the human constitutive androstane receptor (hCAR).

Compound Libraries

Clotrimazole is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 344.84
Formula C22H17ClN2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 23593-75-1
PubChem ID 2812
InChI Key VNFPBHJOKIVQEB-UHFFFAOYSA-N
Smiles ClC1=CC=CC=C1C(C3=CC=CC=C3)(C4=CC=CC=C4)N2C=CN=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.86 75
ethanol 34.48 100

Preparing Stock Solutions

The following data is based on the product molecular weight 344.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.9 mL 14.5 mL 29 mL
5 mM 0.58 mL 2.9 mL 5.8 mL
10 mM 0.29 mL 1.45 mL 2.9 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Snajdrova et al (1998) Clomitrazole, an antimycotic drug, inhibits the sarcoplasmic reticulum calcium pump and contractile function in heart muscle. J.Biol.Chem. 273 28032 PMID: 9774419

Wu et al (1999) Inhibition of Ca2+-activated K+ current by clotrimazole in rat anterior pituitary GH3 cells. Neuropharmacology 38 979 PMID: 10428416

Thomas et al (1999) The antifungal antibiotic clotrimazole potently inhibits L-type calcium current in guinea-pig ventricular myocytes. Br.J.Pharmacol. 126 1531 PMID: 10323582

Lempiainen et al (2005) Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with corepressor protein. Mol.Endocrinol. 19 2258 PMID: 15905360


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Keywords: Clotrimazole, supplier, inhibits, calcium-activated, potassium, channels, Ca2+-activated, K+, channels, inhibitors, antifungal, antimycotic, cytochrome, P450, oxidase, CLT, Cytochrome, P450, Constitutive, Androstane, Receptor, Cytochrome, P450, Tocris Bioscience

Citations for Clotrimazole

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Pathways for Clotrimazole

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