Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Galeterone is a CYP17 inhibitor (IC50 = 300 nM) and androgen receptor antagonist (IC50 = 384 nM in PC3-AR cells). Inhibits DHT-stimulated prostate cancer cell proliferation in vitro. Exhibits antitumor activity in SCID mice bearing prostate cancer xenografts.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 388.55. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.15 mL||25.74 mL||51.47 mL|
|2.5 mM||1.03 mL||5.15 mL||10.29 mL|
|5 mM||0.51 mL||2.57 mL||5.15 mL|
|25 mM||0.1 mL||0.51 mL||1.03 mL|
References are publications that support the biological activity of the product.
Njar & Brodie et al (2015) Discovery and development of Galeterone (TOK-001 or VN/124-1) for the treatment of all stages of prostate cancer. J.Med.Chem. 58 2077 PMID: 25591066
Handratta et al (2005) Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model. J.Med.Chem. 48 2972 PMID: 15828836
If you know of a relevant reference for Galeterone, please let us know.
Keywords: Galeterone, Galeterone supplier, CYP17, inhibitors, inhibits, androgen, receptors, antagonists, antagonsim, anticancer, TOK-001, VN/124-1, Cytochrome, P450, Androgen, Receptor, 6108, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for Galeterone. Do you know of a great paper that uses Galeterone from Tocris? Please let us know.
There are currently no reviews for this product. Be the first to review Galeterone and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image