Potent, reversible non-steroidal aromatase inhibitor (IC50 = 11.5 nM). Displays antitumor effects in several animal models. Suppresses the endogenous aromatase-induced proliferation of MCF-7 cells.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 285.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.51 mL||17.53 mL||35.05 mL|
|5 mM||0.7 mL||3.51 mL||7.01 mL|
|10 mM||0.35 mL||1.75 mL||3.51 mL|
|50 mM||0.07 mL||0.35 mL||0.7 mL|
References are publications that support the products' biological activity.
Mitropoulou et al (2003) Letrozole as a potent inhibitor of cell proliferation and expression of metalloproteinases (MMP-2 and MMP-9) by human epithelial breast cancer cells. Int.J.Cancer 104 155 PMID: 12569569
Bhatnagar et al (1990) Highly selective inhbition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor. J.Steroid Biochem.Mol.Biol. 37 1021 PMID: 2149502
Bhatnagar (2007) The discovery and mechanism of action of letrozole. Breast Cancer Res.Treat. 105 7 PMID: 17912633
If you know of a relevant reference for Letrozole, please let us know.
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Keywords: Letrozole, supplier, CGS20267, non-steroidal, aromatase, CYP19, inhibitors, inhibits, potent, reversible, antitumor, antitumour, CGS, 20267, Cytochrome, P450, Estrogen, and, Related, Receptors, Cytochrome, P450, Tocris Bioscience
2 Citations for Letrozole
Citations are publications that use Tocris products. Selected citations for Letrozole include:
Ruiz-Palmero et al (2016) Oestradiol synthesized by female neurons generates sex differences in neuritogenesis. Scientific Reports 6 31891 PMID: 27553191
Tozzi et al (2015) Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system. Front Cell Neurosci 9 192 PMID: 26074768
Do you know of a great paper that uses Letrozole from Tocris? If so please let us know.
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Literature in this Area
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New Product Guide (Spring/Summer 2017)
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