Letrozole

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Cat.No. 4382 - Letrozole | C17H11N5 | CAS No. 112809-51-5
Description: Potent, reversible non-steroidal aromatase inhibitor
Alternative Names: CGS 20267
Chemical Name: 4,4'-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Potent, reversible non-steroidal aromatase inhibitor (IC50 = 11.5 nM). Displays antitumor effects in several animal models. Suppresses the endogenous aromatase-induced proliferation of MCF-7 cells.

Compound Libraries

Letrozole is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 285.3
Formula C17H11N5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 112809-51-5
PubChem ID 3902
InChI Key HPJKCIUCZWXJDR-UHFFFAOYSA-N
Smiles N#CC(C=C2)=CC=C2C(N3N=CN=C3)C1=CC=C(C#N)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.53 100

Preparing Stock Solutions

The following data is based on the product molecular weight 285.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.51 mL 17.53 mL 35.05 mL
5 mM 0.7 mL 3.51 mL 7.01 mL
10 mM 0.35 mL 1.75 mL 3.51 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Mitropoulou et al (2003) Letrozole as a potent inhibitor of cell proliferation and expression of metalloproteinases (MMP-2 and MMP-9) by human epithelial breast cancer cells. Int.J.Cancer 104 155 PMID: 12569569

Bhatnagar et al (1990) Highly selective inhbition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor. J.Steroid Biochem.Mol.Biol. 37 1021 PMID: 2149502

Bhatnagar (2007) The discovery and mechanism of action of letrozole. Breast Cancer Res.Treat. 105 7 PMID: 17912633


If you know of a relevant reference for Letrozole, please let us know.

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Keywords: Letrozole, supplier, CGS20267, non-steroidal, aromatase, CYP19, inhibitors, inhibits, potent, reversible, antitumor, antitumour, CGS, 20267, Cytochrome, P450, Estrogen, and, Related, Receptors, Cytochrome, P450, Tocris Bioscience

2 Citations for Letrozole

Citations are publications that use Tocris products. Selected citations for Letrozole include:

Ruiz-Palmero et al (2016) Oestradiol synthesized by female neurons generates sex differences in neuritogenesis. Scientific Reports 6 31891 PMID: 27553191

Tozzi et al (2015) Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system. Front Cell Neurosci 9 192 PMID: 26074768


Do you know of a great paper that uses Letrozole from Tocris? If so please let us know.

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Literature in this Area

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New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

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Pathways for Letrozole

Protocols

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