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Potent CYP17A1 inhibitor (IC50 values are 17 nM and 18 nM for 17,20-lyase activity and 17α-hydroxylase activity, respectively. Inhibits intratumor androgen synthesis in prostate cancer.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 391.55. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.55 mL||12.77 mL||25.54 mL|
|5 mM||0.51 mL||2.55 mL||5.11 mL|
|10 mM||0.26 mL||1.28 mL||2.55 mL|
|50 mM||0.05 mL||0.26 mL||0.51 mL|
References are publications that support the biological activity of the product.
Potter et al (1995) Novel steroidal inhibitors of human cytochrome P45017α (l7α-Hydroxylase-Cl7,20-lyase): potential agents for the treatment of prostatic cancer. J.Med.Chem. 38 2463 PMID: 7608911
Barrie et al (1994) Pharmacology of novel steroidal inhibitors of cytochrome P450(17) alpha (17 alpha-hydroxylase/C17-20 lyase). J.Steroid Biochem.Mol.Biol. 50 267 PMID: 7918112
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Keywords: Abiraterone acetate, Abiraterone acetate supplier, Potent, cytochrome, P450, CYP17A1, inhibitors, inhibits, CYP450c17, 17,20-lyase, 17alpha-hydroxylase, androgen, synthesis, prostate, cancer, Cytochrome, 6520, Tocris Bioscience
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