Abiraterone acetate

Pricing Availability   Qty
Description: Potent CYP17A1 inhibitor
Chemical Name: (3β)-17-(3-Pyridinyl)androsta-5,16-dien-3-yl acetate
Purity: ≥98% (HPLC)

Biological Activity for Abiraterone acetate

Abiraterone acetate is a potent CYP17A1 inhibitor (IC50 values are 17 nM and 18 nM for 17,20-lyase activity and 17α-hydroxylase activity, respectively). Inhibits intratumor androgen synthesis in prostate cancer.

Compound Libraries for Abiraterone acetate

Abiraterone acetate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Abiraterone acetate

M. Wt 391.55
Formula C26H33NO2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 154229-18-2
PubChem ID 9821849
Smiles [H][C@@]12CC=C([C@]1(CC[C@]3([C@]2(CC=C4C[C@@H](OC(C)=O)CC[C@]34C)[H])[H])C)C5=CN=CC=C5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Abiraterone acetate

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 7.83 20
ethanol 39.16 100

Preparing Stock Solutions for Abiraterone acetate

The following data is based on the product molecular weight 391.55. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.77 mL 25.54 mL
5 mM 0.51 mL 2.55 mL 5.11 mL
10 mM 0.26 mL 1.28 mL 2.55 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Product Datasheets for Abiraterone acetate

References for Abiraterone acetate

References are publications that support the biological activity of the product.

Potter et al (1995) Novel steroidal inhibitors of human cytochrome P45017α (l7α-Hydroxylase-Cl7,20-lyase): potential agents for the treatment of prostatic cancer. J.Med.Chem. 38 2463 PMID: 7608911

Barrie et al (1994) Pharmacology of novel steroidal inhibitors of cytochrome P450(17) alpha (17 alpha-hydroxylase/C17-20 lyase). J.Steroid Biochem.Mol.Biol. 50 267 PMID: 7918112

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Keywords: Abiraterone acetate, Abiraterone acetate supplier, Potent, cytochrome, P450, CYP17A1, inhibitors, inhibits, CYP450c17, 17,20-lyase, 17alpha-hydroxylase, androgen, synthesis, prostate, cancer, Cytochrome, 6520, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Abiraterone acetate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Abiraterone acetate

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