Ketoconazole

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Cat.No. 1103 - Ketoconazole | C26H28Cl2N4O4 | CAS No. 65277-42-1
Description: Cytochrome P450c17 inhibitor
Chemical Name: cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl] methoxy]phenyl]piperazine
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Antifungal agent; potent inhibitor of cytochrome P450c17.

Technical Data

M. Wt 531.44
Formula C26H28Cl2N4O4
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 65277-42-1
PubChem ID 456201
InChI Key XMAYWYJOQHXEEK-OZXSUGGESA-N
Smiles ClC1=CC(Cl)=[C@]([C@]3(OC[C@@](COC4=CC=C(N5CCN(C(C)=O)CC5)C=C4)([H])O3)CN2C=CN=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.86 75
ethanol 26.57 50

Preparing Stock Solutions

The following data is based on the product molecular weight 531.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.88 mL 9.41 mL 18.82 mL
5 mM 0.38 mL 1.88 mL 3.76 mL
10 mM 0.19 mL 0.94 mL 1.88 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Ayub and Levell (1989) Inhibition of human adrenal steroidogenic enzymes in vitro by imidazole drugs including ketoconazole. J.Steroid Biochem. 32 515 PMID: 2724954

Dumaine et al (1998) Blockade of HERG and Kv1.5 by ketoconazole. J.Pharmacol.Exp.Ther. 286 727 PMID: 9694927

Kuhn-Velten et al (1992) Ketoconazole inhibition of the bifunctional cytochrome P450c17 does not affect androgen formation from the endogenous lyase substrate. Biochem.Pharmacol. 44 2371 PMID: 1472102

Merck Index 12 5313 PMID:


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Keywords: Ketoconazole, supplier, Cytochrome, P450c17, inhibitors, inhibits, CYP, Cytochrome, P450, Cytochrome, P450, Tocris Bioscience

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