You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for Cinacalcet hydrochloride
Cinacalcet hydrochloride is a calcium-sensing receptor (CaSR) allosteric agonist. Activates CaSR signaling in cellular proliferation and phosphatidylinositol (PI) hydrolysis assays. Reduces serum parathyroid hormone levels in rats. Also potent CYP2D2 inhibitor (IC50 = 87 nM) and L-type calcium channel blocker. Orally bioavailable.
Compound Libraries for Cinacalcet hydrochloride
Technical Data for Cinacalcet hydrochloride
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Cinacalcet hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Cinacalcet hydrochloride
The following data is based on the product molecular weight 393.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.54 mL||12.69 mL||25.39 mL|
|5 mM||0.51 mL||2.54 mL||5.08 mL|
|10 mM||0.25 mL||1.27 mL||2.54 mL|
|50 mM||0.05 mL||0.25 mL||0.51 mL|
Product Datasheets for Cinacalcet hydrochloride
References for Cinacalcet hydrochloride
References are publications that support the biological activity of the product.
Goodman et al (2002) The calcimimetic agent AMG 073 lowers plasma parathyroid hormone levels in hemodialysis patients with secondary hyperparathyroidism. J.Am.Soc.Nephrol. 13 1017 PMID: 11912261
Ma et al (2011) Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor. J.Pharmacol.Exp.Ther. 337 275 PMID: 21239511
If you know of a relevant reference for Cinacalcet hydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Cinacalcet hydrochloride, Cinacalcet hydrochloride supplier, AMG073, calcium-sensing, receptor, CaSR, allosteric, agonists, agonism, calcimimetic, CYP2D2, inhibitors, inhibits, L-type, calcium, channel, blockers, Sensipar, AMG, 073, Calcium-Sensing, Receptor, Cytochrome, P450, Cav1.x, Channels, 6170, Tocris Bioscience
2 Citations for Cinacalcet hydrochloride
Citations are publications that use Tocris products. Selected citations for Cinacalcet hydrochloride include:
Stephen D et al (2021) Area Postrema Cell Types that Mediate Nausea-Associated Behaviors. Neuron 109 461-472.e5 PMID: 33278342
Ian P et al (2023) Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation. Cell Signal 107 110676 PMID: 37028778
Do you know of a great paper that uses Cinacalcet hydrochloride from Tocris? Please let us know.
Reviews for Cinacalcet hydrochloride
There are currently no reviews for this product. Be the first to review Cinacalcet hydrochloride and earn rewards!
Have you used Cinacalcet hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image