Calcium-sensing receptor (CaSR) allosteric agonist. Activates CaSR signaling in cellular proliferation and phosphatidylinositol (PI) hydrolysis assays. Reduces serum parathyroid hormone levels in rats. Also potent CYP2D2 inhibitor (IC50 = 87 nM) and L-type calcium channel blocker. Orally bioavailable.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 393.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.54 mL||12.69 mL||25.39 mL|
|5 mM||0.51 mL||2.54 mL||5.08 mL|
|10 mM||0.25 mL||1.27 mL||2.54 mL|
|50 mM||0.05 mL||0.25 mL||0.51 mL|
References are publications that support the biological activity of the product.
Goodman et al (2002) The calcimimetic agent AMG 073 lowers plasma parathyroid hormone levels in hemodialysis patients with secondary hyperparathyroidism. J.Am.Soc.Nephrol. 13 1017 PMID: 11912261
Ma et al (2011) Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor. J.Pharmacol.Exp.Ther. 337 275 PMID: 21239511
If you know of a relevant reference for Cinacalcet hydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Cinacalcet hydrochloride, Cinacalcet hydrochloride supplier, AMG073, calcium-sensing, receptor, CaSR, allosteric, agonists, agonism, calcimimetic, CYP2D2, inhibitors, inhibits, L-type, calcium, channel, blockers, Sensipar, AMG, 073, Calcium-Sensing, Receptor, Cytochrome, P450, Cav1.x, Channels, 6170, Tocris Bioscience
Citations for Cinacalcet hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for Cinacalcet hydrochloride. Do you know of a great paper that uses Cinacalcet hydrochloride from Tocris? Please let us know.
Reviews for Cinacalcet hydrochloride
There are currently no reviews for this product. Be the first to review Cinacalcet hydrochloride and earn rewards!
Have you used Cinacalcet hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.