Bradykinin and related kinins are a family of small peptides which act as mediators of pain and inflammation. They exert a variety of biological effects on the endothelium and peripheral circulation through their action on two bradykinin receptor subtypes: B1 and B2.
Agonists |
Cat. No. | Product Name / Activity |
---|---|
2371 | Bombinakinin M |
Potent bradykinin agonist | |
3004 | Bradykinin |
Endogenous agonist at bradykinin receptors (B2 > B1) | |
3230 | Sar-[D-Phe8]-des-Arg9-Bradykinin |
Potent and selective B1 agonist | |
3229 | [Phe8Ψ(CH-NH)-Arg9]-Bradykinin |
Selective B2 agonist | |
3225 | Lys-[Des-Arg9]Bradykinin |
Selective B1 agonist | |
Antagonists |
Cat. No. | Product Name / Activity |
3014 | HOE 140 |
Potent and selective B2 antagonist | |
3978 | MEN 11270 |
Selective B2 antagonist; analog of HOE 140 (Cat. No. 3014) | |
1697 | Noscapine hydrochloride |
Bradykinin antagonist; also tubulin inhibitor | |
3407 | R 715 |
Potent and selective B1 antagonist | |
3226 | R 892 |
Potent and selective B1 antagonist | |
1057 | WIN 64338 hydrochloride |
Bradykinin B2 antagonist | |
Other |
Cat. No. | Product Name / Activity |
2370 | Bombinakinin-GAP |
Bioactive, bradykinin-related peptide |
Bradykinin and related kinins are a family of small peptides which act as mediators of pain and inflammation. They exert a variety of biological effects on the endothelium and peripheral circulation through their action on two G-protein-coupled bradykinin receptor subtypes, the B1 receptor and the B2 receptor. Bradykinin is an important pro-inflammatory molecule that causes vasodilation, plasma protein extravasation, smooth muscle contraction and pain.
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