Bradykinin Receptors
Bradykinin and related kinins are a family of small peptides which act as mediators of pain and inflammation. They exert a variety of biological effects on the endothelium and peripheral circulation through their action on two bradykinin receptor subtypes: B1 and B2.
Bradykinin Receptor Agonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 3004 | Bradykinin |
| Endogenous agonist at bradykinin receptors (B2 > B1) | |
| 3229 | [Phe8Ψ(CH-NH)-Arg9]-Bradykinin |
| Selective B2 agonist | |
| 3225 | Lys-[Des-Arg9]Bradykinin |
| Selective B1 agonist | |
Bradykinin Receptor Antagonists |
|
| Cat. No. | Product Name / Activity |
| 3014 | HOE 140 |
| Potent and selective B2 antagonist | |
| 3407 | R 715 |
| Potent and selective B1 antagonist | |
| 1057 | WIN 64338 hydrochloride |
| Bradykinin B2 antagonist | |
Bradykinin and related kinins are a family of small peptides which act as mediators of pain and inflammation. They exert a variety of biological effects on the endothelium and peripheral circulation through their action on two G-protein-coupled bradykinin receptor subtypes, the B1 receptor and the B2 receptor. Bradykinin is an important pro-inflammatory molecule that causes vasodilation, plasma protein extravasation, smooth muscle contraction and pain.