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Bradykinin Receptors

Bradykinin and related kinins are a family of small peptides which act as mediators of pain and inflammation. They exert a variety of biological effects on the endothelium and peripheral circulation through their action on two bradykinin receptor subtypes: B1 and B2.

Products
Background
Literature (4)
Gene Data

Agonists
Cat. No. Product Name / Activity
2371 Bombinakinin M
Potent bradykinin agonist
3004 Bradykinin
Endogenous agonist at bradykinin receptors (B2 > B1)
3230 Sar-[D-Phe8]-des-Arg9-Bradykinin
Potent and selective B1 agonist
3229 [Phe8Ψ(CH-NH)-Arg9]-Bradykinin
Selective B2 agonist
3227 Lys-Bradykinin
Potent bradykinin agonist (B2 > B1)
3225 Lys-[Des-Arg9]Bradykinin
Selective B1 agonist

Antagonists
Cat. No. Product Name / Activity
3014 HOE 140
Potent and selective B2 antagonist
3978 MEN 11270
Selective B2 antagonist; analog of HOE 140 (Cat. No. 3014)
1697 Noscapine hydrochloride
Bradykinin antagonist; also tubulin inhibitor
3407 R 715
Potent and selective B1 antagonist
3226 R 892
Potent and selective B1 antagonist
1057 WIN 64338 hydrochloride
Bradykinin B2 antagonist

Other
Cat. No. Product Name / Activity
2370 Bombinakinin-GAP
Bioactive, bradykinin-related peptide
6190 Retrobradykinin
Reverse analog of Bradykinin

Bradykinin and related kinins are a family of small peptides which act as mediators of pain and inflammation. They exert a variety of biological effects on the endothelium and peripheral circulation through their action on two G-protein-coupled bradykinin receptor subtypes, the B1 receptor and the B2 receptor. Bradykinin is an important pro-inflammatory molecule that causes vasodilation, plasma protein extravasation, smooth muscle contraction and pain.

External sources of pharmacological information for Bradykinin Receptors :

Literature for Bradykinin Receptors

Tocris offers the following scientific literature for Bradykinin Receptors to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GPCR

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Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Peptide Hormone Receptors

Peptide Hormone Receptors Product Listing

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Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Bradykinin Receptor Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
B1 Human BDKRB1 NM_000710 P46663
Mouse Bdkrb1 NM_007539 Q61125
Rat Bdkrb1 NM_030851 P97583
B2 Human BDKRB2 NM_000623 P30411
Mouse Bdkrb2 NM_009747 P32299
Rat Bdkrb2 NM_173100 P25023