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Bradykinin Receptors

Bradykinin and related kinins are a family of small peptides which act as mediators of pain and inflammation. They exert a variety of biological effects on the endothelium and peripheral circulation through their action on two bradykinin receptor subtypes: B1 and B2.

Products
Background
Literature (4)
Gene Data

Bradykinin Receptor Agonists
Cat. No. Product Name / Activity
3004 Bradykinin
Endogenous agonist at bradykinin receptors (B2 > B1)
3229 [Phe8Ψ(CH-NH)-Arg9]-Bradykinin
Selective B2 agonist
3225 Lys-[Des-Arg9]Bradykinin
Selective B1 agonist

Bradykinin Receptor Antagonists
Cat. No. Product Name / Activity
3014 HOE 140
Potent and selective B2 antagonist
3407 R 715
Potent and selective B1 antagonist
1057 WIN 64338 hydrochloride
Bradykinin B2 antagonist

Bradykinin and related kinins are a family of small peptides which act as mediators of pain and inflammation. They exert a variety of biological effects on the endothelium and peripheral circulation through their action on two G-protein-coupled bradykinin receptor subtypes, the B1 receptor and the B2 receptor. Bradykinin is an important pro-inflammatory molecule that causes vasodilation, plasma protein extravasation, smooth muscle contraction and pain.

External sources of pharmacological information for Bradykinin Receptors :

Literature for Bradykinin Receptors

Tocris offers the following scientific literature for Bradykinin Receptors to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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Bradykinin Receptor Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
B1 Human BDKRB1 NM_000710 P46663
Mouse Bdkrb1 NM_007539 Q61125
Rat Bdkrb1 NM_030851 P97583
B2 Human BDKRB2 NM_000623 P30411
Mouse Bdkrb2 NM_009747 P32299
Rat Bdkrb2 NM_173100 P25023