Potent and selective bradykinin B2 receptor antagonist (pA2 = 9.04). Also inhibits aminopeptidase N (Ki = 9.1 μM).
(Modifications: Arg-1 = D-Arg, X-4 = Hyp, X-6 = Thi, X-8 = D-Tic, X-9 = Oic)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1304.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.77 mL||3.83 mL||7.67 mL|
|5 mM||0.15 mL||0.77 mL||1.53 mL|
|10 mM||0.08 mL||0.38 mL||0.77 mL|
|50 mM||0.02 mL||0.08 mL||0.15 mL|
References are publications that support the biological activity of the product.
Hock et al (1991) Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br.J.Pharmacol. 102 769 PMID: 1364851
Feletou et al (1994) Agonistic and antagonistic properties of the bradykinin B2 receptor antagonist, Hoe 140, in isolated blood vessels from different species. Br.J.Pharmacol. 112 683 PMID: 8075888
Bawolak et al (2006) The bradykinin B2 receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B1 and angiotensin receptors. Eur.J.Pharmacol. 551 108 PMID: 17026984
If you know of a relevant reference for HOE 140, please let us know.
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Keywords: HOE 140, HOE 140 supplier, Potent, selective, B2, antagonists, Receptors, Bradykinin, HOE140, Icatibant, 3014, Tocris Bioscience
4 Citations for HOE 140
Citations are publications that use Tocris products. Selected citations for HOE 140 include:
Brailoiu (2017) Modulation of cardiac vagal tone by bradykinin acting on nucleus ambiguus. Neuroscience 365 23 PMID: 28951324
Kawaguchi et al (2015) Functional expression of bradykinin B1 and B2 receptors in neonatal rat trigeminal ganglion neurons. Oncogene 9 229 PMID: 26124706
Raffai et al (2016) Angiotensin-(1-7) selectively induces relaxation and modulates endothelium-dependent dilation in mesenteric arteries of salt-fed rats Journal of Vascular Research 53 105 PMID: 27676088
Xu et al (2014) Nicotine exaggerates LPS-induced airway hyperreactivity via JNK-mediated up-regulation of Toll-like receptor 4. Am J Respir Cell Mol Biol 51 370 PMID: 24669857
Do you know of a great paper that uses HOE 140 from Tocris? Please let us know.
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Literature in this Area
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