HOE 140

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Cat.No. 3014 - HOE 140 | D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg | CAS No. 130308-48-4
Description: Potent and selective B2 antagonist
Alternative Names: Icatibant
Datasheet
Citations (2)
Literature

Biological Activity

Potent and selective bradykinin B2 receptor antagonist (pA2 = 9.04). Also inhibits aminopeptidase N (Ki = 9.1 μM).

Technical Data

M. Wt 1304.52
Formula C59H89N19O13S
Sequence RRPXGXSXXR

(Modifications: Arg-1 = D-Arg, X-4 = Hyp, X-6 = Thi, X-8 = Tic, X-9 = Oic)

Storage Store at -20°C
CAS Number 130308-48-4
PubChem ID 90488794
InChI Key QURWXBZNHXJZBE-JNFYKTHFSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@H](CC1=CC=CS1)C(=O)N[C@@H](CO)C(=O)N1CC2=C(C[C@@H]1C(=O)N1C3CCCCC3C[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1304.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.77 mL 3.83 mL 7.67 mL
5 mM 0.15 mL 0.77 mL 1.53 mL
10 mM 0.08 mL 0.38 mL 0.77 mL
50 mM 0.02 mL 0.08 mL 0.15 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hock et al (1991) Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br.J.Pharmacol. 102 769 PMID: 1364851

Feletou et al (1994) Agonistic and antagonistic properties of the bradykinin B2 receptor antagonist, Hoe 140, in isolated blood vessels from different species. Br.J.Pharmacol. 112 683 PMID: 8075888

Bawolak et al (2006) The bradykinin B2 receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B1 and angiotensin receptors. Eur.J.Pharmacol. 551 108 PMID: 17026984


If you know of a relevant reference for HOE 140, please let us know.

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View all Bradykinin Receptor Antagonists

Keywords: Potent selective B2 antagonists Receptors Bradykinin HOE140 Icatibant Bradykinin Receptors

2 Citations for HOE 140

Citations are publications that use Tocris products. Selected citations for HOE 140 include:

Raffai et al (2016) Angiotensin-(1-7) selectively induces relaxation and modulates endothelium-dependent dilation in mesenteric arteries of salt-fed rats Journal of Vascular Research 53 105 PMID: 27676088

Kawaguchi et al (2015) Functional expression of bradykinin B1 and B2 receptors in neonatal rat trigeminal ganglion neurons. Oncogene 9 229 PMID: 26124706


Do you know of a great paper that uses HOE 140 from Tocris? If so please let us know.

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Pathways for HOE 140

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