HOE 140

Pricing Availability   Qty
Description: Potent and selective B2 antagonist
Alternative Names: Icatibant
Purity: ≥95% (HPLC)
Datasheet
Citations (5)
Reviews (1)

Biological Activity for HOE 140

HOE 140 is a potent and selective bradykinin B2 receptor antagonist (pA2 = 9.04). Also inhibits aminopeptidase N (Ki = 9.1 μM).

Technical Data for HOE 140

M. Wt 1304.52
Formula C59H89N19O13S
Sequence RRPXGXSXXR

(Modifications: Arg-1 = D-Arg, X-4 = Hyp, X-6 = Thi, X-8 = D-Tic, X-9 = Oic)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 130308-48-4
PubChem ID 90488794
InChI Key QURWXBZNHXJZBE-JNFYKTHFSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@H](CC1=CC=CS1)C(=O)N[C@@H](CO)C(=O)N1CC2=C(C[C@@H]1C(=O)N1C3CCCCC3C[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for HOE 140

Solubility Soluble to 1 mg/ml in water

Product Datasheets for HOE 140

Certificate of Analysis / Product Datasheet
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References for HOE 140

References are publications that support the biological activity of the product.

Hock et al (1991) Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br.J.Pharmacol. 102 769 PMID: 1364851

Feletou et al (1994) Agonistic and antagonistic properties of the bradykinin B2 receptor antagonist, Hoe 140, in isolated blood vessels from different species. Br.J.Pharmacol. 112 683 PMID: 8075888

Bawolak et al (2006) The bradykinin B2 receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B1 and angiotensin receptors. Eur.J.Pharmacol. 551 108 PMID: 17026984


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Keywords: HOE 140, HOE 140 supplier, Potent, selective, B2, antagonists, Receptors, Bradykinin, HOE140, Icatibant, 3014, Tocris Bioscience

5 Citations for HOE 140

Citations are publications that use Tocris products. Selected citations for HOE 140 include:

Raffai et al (2016) Angiotensin-(1-7) selectively induces relaxation and modulates endothelium-dependent dilation in mesenteric arteries of salt-fed rats Journal of Vascular Research 53 105 PMID: 27676088

Xu et al (2014) Nicotine exaggerates LPS-induced airway hyperreactivity via JNK-mediated up-regulation of Toll-like receptor 4. Am J Respir Cell Mol Biol 51 370 PMID: 24669857

Kawaguchi et al (2015) Functional expression of bradykinin B1 and B2 receptors in neonatal rat trigeminal ganglion neurons. Oncogene 9 229 PMID: 26124706

Brailoiu (2017) Modulation of cardiac vagal tone by bradykinin acting on nucleus ambiguus. Neuroscience 365 23 PMID: 28951324


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Reviews for HOE 140

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works good.
By Anonymous on 05/13/2020
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: neurons

B2 receptor blocker HOE140, 200 nM

treat 20 min

PMID: 28951324 Reference
review image