WIN 64338 hydrochloride

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Cat.No. 1057 - WIN 64338 hydrochloride | C45H68ClN4OP.HCl | CAS No. 163727-74-0
Description: Bradykinin B2 antagonist
Chemical Name: (S)-4-[2-[Bis(cyclohexylamino)methyleneamino]-3-(2-naphthalenyl)-1-oxopropylamino]benzyl tributyl phosphonium chloride hydrochloride
Datasheet
Citations (1)
Reviews
Literature (4)

Biological Activity

The first potent, non-peptide, competitive bradykinin B2 receptor antagonist. In organ bath studies, WIN 64338 inhibits [3H]-bradykinin binding on guinea pig trachea with nanomolar affinity but is not active in the rabbit aorta (the classical bradykinin B1 preparation).

Technical Data

M. Wt 783.95
Formula C45H68ClN4OP.HCl
Storage Desiccate at +4°C
CAS Number 163727-74-0
PubChem ID 9832172
InChI Key YYJGBEZPVOUBMJ-KRFCICRISA-N
Smiles CCCC[P+](CCCC)(CC1=CC=C(C=C1)NC([C@@H](/N=C(NC2CCCCC2)/NC3CCCCC3)CC4=CC5=CC=CC=C5C=C4)=O)CCCC.Cl.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 58.8 75

Preparing Stock Solutions

The following data is based on the product molecular weight 783.95. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 1.7 mL 8.5 mL 17.01 mL
3.75 mM 0.34 mL 1.7 mL 3.4 mL
7.5 mM 0.17 mL 0.85 mL 1.7 mL
37.5 mM 0.03 mL 0.17 mL 0.34 mL

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References

References are publications that support the biological activity of the product.

Hu et al (2004) Action of bradykinin in the submucosal plexus of guinea pig small intestine. J.Pharmacol.Exp.Ther. 309 320 PMID: 14718600

Marceau et al (1994) Effects of peptide and nonpeptide antagonists of bradykinin B2 receptors on the venoconstrictor action of bradykinin. J.Pharmacol.Exp.Ther. 269 1136 PMID: 8014858

Scherrer et al (1995) Effects of WIN 64338, a nonpeptide bradykinin B2 receptor antagonist, on guinea-pig trachea. Br.J.Pharmacol. 115 1127 PMID: 7582533


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1 Citation for WIN 64338 hydrochloride

Citations are publications that use Tocris products. Selected citations for WIN 64338 hydrochloride include:

Gross et al (2013) Factors mediating remote preconditioning of trauma in the rat heart: central role of the cytochrome p450 epoxygenase pathway in mediating infarct size reduction. J Cardiovasc Pharmacol Ther 18 38 PMID: 22407888


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Literature in this Area

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