WIN 64338 hydrochloride

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Cat.No. 1057 - WIN 64338 hydrochloride | C45H68ClN4OP.HCl | CAS No. 163727-74-0
Description: Bradykinin B2 antagonist
Chemical Name: (S)-4-[2-[Bis(cyclohexylamino)methyleneamino]-3-(2-naphthalenyl)-1-oxopropylamino]benzyl tributyl phosphonium chloride hydrochloride
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

The first potent, non-peptide, competitive bradykinin B2 receptor antagonist. In organ bath studies, WIN 64338 inhibits [3H]-bradykinin binding on guinea pig trachea with nanomolar affinity but is not active in the rabbit aorta (the classical bradykinin B1 preparation).

Compound Libraries

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Technical Data

M. Wt 783.95
Formula C45H68ClN4OP.HCl
Storage Desiccate at +4°C
CAS Number 163727-74-0
PubChem ID 9832172
InChI Key YYJGBEZPVOUBMJ-KRFCICRISA-N
Smiles O=C(NC5=CC=C(C[P+](CCCC)(CCCC)CCCC)C=C5)[C@H](CC3=CC=C(C=CC=C4)C4=C3)NC(NC2CCCCC2)=NC1CCCCC1.Cl.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 58.8 75

Preparing Stock Solutions

The following data is based on the product molecular weight 783.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.28 mL 6.38 mL 12.76 mL
5 mM 0.26 mL 1.28 mL 2.55 mL
10 mM 0.13 mL 0.64 mL 1.28 mL
50 mM 0.03 mL 0.13 mL 0.26 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hu et al (2004) Action of bradykinin in the submucosal plexus of guinea pig small intestine. J.Pharmacol.Exp.Ther. 309 320 PMID: 14718600

Marceau et al (1994) Effects of peptide and nonpeptide antagonists of bradykinin B2 receptors on the venoconstrictor action of bradykinin. J.Pharmacol.Exp.Ther. 269 1136 PMID: 8014858

Scherrer et al (1995) Effects of WIN 64338, a nonpeptide bradykinin B2 receptor antagonist, on guinea-pig trachea. Br.J.Pharmacol. 115 1127 PMID: 7582533


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Keywords: WIN 64338 hydrochloride, supplier, Bradykinin, B2, antagonists, Receptors, WIN64338, hydrochloride, Bradykinin, Receptors, Bradykinin, Receptors, Tocris Bioscience

1 Citation for WIN 64338 hydrochloride

Citations are publications that use Tocris products. Selected citations for WIN 64338 hydrochloride include:

Gross et al (2013) Factors mediating remote preconditioning of trauma in the rat heart: central role of the cytochrome p450 epoxygenase pathway in mediating infarct size reduction. J Cardiovasc Pharmacol Ther 18 38 PMID: 22407888


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