WIN 64338 hydrochloride

Pricing Availability   Qty
Description: Bradykinin B2 antagonist
Chemical Name: (S)-4-[2-[Bis(cyclohexylamino)methyleneamino]-3-(2-naphthalenyl)-1-oxopropylamino]benzyl tributyl phosphonium chloride hydrochloride
Citations (1)

Biological Activity for WIN 64338 hydrochloride

WIN 64338 hydrochloride is a the first potent, non-peptide, competitive bradykinin B2 receptor antagonist. In organ bath studies, WIN 64338 inhibits [3H]-bradykinin binding on guinea pig trachea with nanomolar affinity but is not active in the rabbit aorta (the classical bradykinin B1 preparation).

Technical Data for WIN 64338 hydrochloride

M. Wt 783.95
Formula C45H68ClN4OP.HCl
Storage Desiccate at +4°C
CAS Number 163727-74-0
PubChem ID 9832172

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for WIN 64338 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 58.8 75

Preparing Stock Solutions for WIN 64338 hydrochloride

The following data is based on the product molecular weight 783.95. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 1.7 mL 8.5 mL 17.01 mL
3.75 mM 0.34 mL 1.7 mL 3.4 mL
7.5 mM 0.17 mL 0.85 mL 1.7 mL
37.5 mM 0.03 mL 0.17 mL 0.34 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for WIN 64338 hydrochloride

References for WIN 64338 hydrochloride

References are publications that support the biological activity of the product.

Hu et al (2004) Action of bradykinin in the submucosal plexus of guinea pig small intestine. J.Pharmacol.Exp.Ther. 309 320 PMID: 14718600

Marceau et al (1994) Effects of peptide and nonpeptide antagonists of bradykinin B2 receptors on the venoconstrictor action of bradykinin. J.Pharmacol.Exp.Ther. 269 1136 PMID: 8014858

Scherrer et al (1995) Effects of WIN 64338, a nonpeptide bradykinin B2 receptor antagonist, on guinea-pig trachea. Br.J.Pharmacol. 115 1127 PMID: 7582533

If you know of a relevant reference for WIN 64338 hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Bradykinin Receptor Antagonists

Keywords: WIN 64338 hydrochloride, WIN 64338 hydrochloride supplier, Bradykinin, B2, antagonists, Receptors, WIN64338, hydrochloride, 1057, Tocris Bioscience

1 Citation for WIN 64338 hydrochloride

Citations are publications that use Tocris products. Selected citations for WIN 64338 hydrochloride include:

Gross et al (2013) Factors mediating remote preconditioning of trauma in the rat heart: central role of the cytochrome p450 epoxygenase pathway in mediating infarct size reduction. J Cardiovasc Pharmacol Ther 18 38 PMID: 22407888

Do you know of a great paper that uses WIN 64338 hydrochloride from Tocris? Please let us know.

Reviews for WIN 64338 hydrochloride

There are currently no reviews for this product. Be the first to review WIN 64338 hydrochloride and earn rewards!

Have you used WIN 64338 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review