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ZD 7155 hydrochloride
A potent and selective competitive antagonist for the angiotensin II type 1 (AT1) receptor. Displaces [125I]-angiotensin II binding with an IC50 value of 3.8 nM in guinea pig adrenal gland membranes. Orally active, and is more potent and longer-acting than the prototype AT1 antagonist, losartan.
Sold with the permission of AstraZeneca UK Ltd.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||4.75||10 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 474.99. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||21.05 mL||105.27 mL||210.53 mL|
|0.5 mM||4.21 mL||21.05 mL||42.11 mL|
|1 mM||2.11 mL||10.53 mL||21.05 mL|
|5 mM||0.42 mL||2.11 mL||4.21 mL|
References are publications that support the biological activity of the product.
Junggren et al (1996) Comparative cardiovascular effects of the angiotensin II type 1 receptor antagonists ZD 7155 and los. in the rat. J.Pharm.Pharmacol. 48 829 PMID: 8887734
Veelken et al (1998) Endogenous angiotensin II and the reflex response to stimulation of cardiopulmonary serotonin 5HT3 receptors. Br.J.Pharmacol. 125 1761 PMID: 9886768
Oldham et al (1993) Zeneca ZD7155: a novel, potent and orally-effective angiotensin II receptor antagonist. Br.J.Pharmacol. 109 P136
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2 Citations for ZD 7155 hydrochloride
Citations are publications that use Tocris products. Selected citations for ZD 7155 hydrochloride include:
Leite-Moreira et al (2006) Angiotensin II acutely decreases myocardial stiffness: a novel AT1, PKC and Na+/H+ exchanger-mediated effect. Br J Pharmacol 147 690 PMID: 16415904
Nostramo et al (2012) Regulation of angiotensin II type 2 receptor gene expression in the adrenal medulla by acute and repeated immobilization stress. Proc Natl Acad Sci U S A 215 291 PMID: 22911895
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