ZD 7155 hydrochloride

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Cat.No. 1211 - ZD 7155 hydrochloride | C26H26N6O.HCl | CAS No. 146709-78-6
Description: Selective non-peptide AT1 antagonist
Chemical Name: 5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (4)

Biological Activity

A potent and selective competitive antagonist for the angiotensin II type 1 (AT1) receptor. Displaces [125I]-angiotensin II binding with an IC50 value of 3.8 nM in guinea pig adrenal gland membranes. Orally active, and is more potent and longer-acting than the prototype AT1 antagonist, losartan.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M. Wt 474.99
Formula C26H26N6O.HCl
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 146709-78-6
PubChem ID 9826191
InChI Key NAGGAAHTUXEGFG-UHFFFAOYSA-N
Smiles Cl.CCC1=CC2=C(CCC(=O)N2CC2=CC=C(C=C2)C2=CC=CC=C2C2=NN=NN2)C(CC)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 4.75 10 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 474.99. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.05 mL 105.27 mL 210.53 mL
0.5 mM 4.21 mL 21.05 mL 42.11 mL
1 mM 2.11 mL 10.53 mL 21.05 mL
5 mM 0.42 mL 2.11 mL 4.21 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Junggren et al (1996) Comparative cardiovascular effects of the angiotensin II type 1 receptor antagonists ZD 7155 and los. in the rat. J.Pharm.Pharmacol. 48 829 PMID: 8887734

Veelken et al (1998) Endogenous angiotensin II and the reflex response to stimulation of cardiopulmonary serotonin 5HT3 receptors. Br.J.Pharmacol. 125 1761 PMID: 9886768

Oldham et al (1993) Zeneca ZD7155: a novel, potent and orally-effective angiotensin II receptor antagonist. Br.J.Pharmacol. 109 P136


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Keywords: ZD 7155 hydrochloride, ZD 7155 hydrochloride supplier, Selective, non-peptide, AT1, antagonists, Receptors, Angiotensin1, ZD7155, hydrochloride, AstraZeneca, Angiotensin, 1211, Tocris Bioscience

2 Citations for ZD 7155 hydrochloride

Citations are publications that use Tocris products. Selected citations for ZD 7155 hydrochloride include:

Leite-Moreira et al (2006) Angiotensin II acutely decreases myocardial stiffness: a novel AT1, PKC and Na+/H+ exchanger-mediated effect. Br J Pharmacol 147 690 PMID: 16415904

Nostramo et al (2012) Regulation of angiotensin II type 2 receptor gene expression in the adrenal medulla by acute and repeated immobilization stress. Proc Natl Acad Sci U S A 215 291 PMID: 22911895


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Literature in this Area

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