CGP 42112

Pricing Availability   Qty
Description: Selective, high affinity AT2 ligand
Purity: ≥95% (HPLC)
Datasheet
Citations (3)
Reviews

Biological Activity for CGP 42112

CGP 42112 is a selective, high affinity angiotensin AT2 receptor ligand (Ki = 0.24 nM). Displays agonistic properties at proximal tubule AT2 receptors, causes Na+, K+-ATPase inhibition and sodium excretion. Antagonizes Ang-II induced contractions in rabbit aortic rings (IC50 = 1850 nM).

Technical Data for CGP 42112

M. Wt 1052.2
Formula C52H69N13O11
Sequence YKHPI

(Modifications: Tyr-1 = N-α-Nicotinoyl, Lys-2 = Lys-(N-α-Z-Arg))

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 127060-75-7
PubChem ID 123794
InChI Key UXGNARZDONUMMK-LRMQDCNJSA-N
Smiles CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCNC(N)=N)NC(=O)OCC1=CC=CC=C1)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)C1=CN=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CGP 42112

Solubility Soluble to 1 mg/ml in water

Product Datasheets for CGP 42112

Certificate of Analysis / Product Datasheet
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References for CGP 42112

References are publications that support the biological activity of the product.

Naveri (1995) The role of angiotensin receptor subtypes in cerebrovascular regulation in the rat. Acta.Physiol.Scand.Suppl. 630 1 PMID: 8610501

Hakam and Hussain (2006) Angiotensin II AT2 receptors inhibit proximal tubular Na+-K+-ATPase activity via a NO/cGMP-dependent pathway. Am.J.Physiol.Renal Physiol. 290 F1430 PMID: 16380464

Criscione et al (1990) Binding characteristics and vascular effects of various angiotensin II antagonists. J.Cardiovas.Pharmacol. 16 S56


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Keywords: CGP 42112, CGP 42112 supplier, Selective, high, affinity, AT2, ligands, Receptors, Angiotensin, CGP42112, 2569, Tocris Bioscience

3 Citations for CGP 42112

Citations are publications that use Tocris products. Selected citations for CGP 42112 include:

Raffai et al (2016) Angiotensin-(1-7) selectively induces relaxation and modulates endothelium-dependent dilation in mesenteric arteries of salt-fed rats Journal of Vascular Research 53 105 PMID: 27676088

Nostramo et al (2012) Regulation of angiotensin II type 2 receptor gene expression in the adrenal medulla by acute and repeated immobilization stress. Stroke 215 291 PMID: 22911895

Li et al (2012) Perinatal nicotine exposure increases vulnerability of hypoxic-ischemic brain injury in neonatal rats: role of angiotensin II receptors. BMC Cancer 43 2483 PMID: 22738920


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