Selective, high affinity angiotensin AT2 receptor ligand (Ki = 0.24 nM). Displays agonistic properties at proximal tubule AT2 receptors, causes Na+, K+-ATPase inhibition and sodium excretion. Antagonizes Ang-II induced contractions in rabbit aortic rings (IC50 = 1850 nM).
(Modifications: Tyr-1 = N-α-Nicotinoyl, Lys-2 = Lys-(N-α-Z-Arg))
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1052.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.95 mL||4.75 mL||9.5 mL|
|5 mM||0.19 mL||0.95 mL||1.9 mL|
|10 mM||0.1 mL||0.48 mL||0.95 mL|
|50 mM||0.02 mL||0.1 mL||0.19 mL|
References are publications that support the products' biological activity.
Naveri (1995) The role of angiotensin receptor subtypes in cerebrovascular regulation in the rat. Acta.Physiol.Scand.Suppl. 630 1 PMID: 8610501
Hakam and Hussain (2006) Angiotensin II AT2 receptors inhibit proximal tubular Na+-K+-ATPase activity via a NO/cGMP-dependent pathway. Am.J.Physiol.Renal Physiol. 290 F1430 PMID: 16380464
If you know of a relevant reference for CGP 42112, please let us know.
Keywords: CGP 42112, supplier, Selective, high, affinity, AT2, ligands, Receptors, Angiotensin, CGP42112, Angiotensin, AT2, Receptors, Angiotensin, AT2, Receptors, Tocris Bioscience
3 Citations for CGP 42112
Citations are publications that use Tocris products. Selected citations for CGP 42112 include:
Raffai et al (2016) Angiotensin-(1-7) selectively induces relaxation and modulates endothelium-dependent dilation in mesenteric arteries of salt-fed rats Journal of Vascular Research 53 105 PMID: 27676088
Nostramo et al (2012) Regulation of angiotensin II type 2 receptor gene expression in the adrenal medulla by acute and repeated immobilization stress. Stroke 215 291 PMID: 22911895
Li et al (2012) Perinatal nicotine exposure increases vulnerability of hypoxic-ischemic brain injury in neonatal rats: role of angiotensin II receptors. BMC Cancer 43 2483 PMID: 22738920
Do you know of a great paper that uses CGP 42112 from Tocris? If so please let us know.
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