CGP 42112

Pricing Availability Delivery Time Qty
Cat.No. 2569 - CGP 42112 | N-α-Nicotinoyl-Tyr-Lys-(N-α-Z-Arg)-His-Pro-Ile | CAS No. 127060-75-7
Description: Selective, high affinity AT2 ligand
Datasheet
Citations (3)
Literature

Biological Activity

Selective, high affinity angiotensin AT2 receptor ligand (Ki = 0.24 nM). Displays agonistic properties at proximal tubule AT2 receptors, causes Na+, K+-ATPase inhibition and sodium excretion. Antagonizes Ang-II induced contractions in rabbit aortic rings (IC50 = 1850 nM).

Technical Data

M. Wt 1052.2
Formula C52H69N13O11
Sequence YKHPI

(Modifications: Tyr-1 = N-α-Nicotinoyl, Lys-2 = Lys-(N-α-Z-Arg))

Storage Desiccate at -20°C
CAS Number 127060-75-7
PubChem ID 123794
InChI Key UXGNARZDONUMMK-LRMQDCNJSA-N
Smiles CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCNC(N)=N)NC(=O)OCC1=CC=CC=C1)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)C1=CN=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1052.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.95 mL 4.75 mL 9.5 mL
5 mM 0.19 mL 0.95 mL 1.9 mL
10 mM 0.1 mL 0.48 mL 0.95 mL
50 mM 0.02 mL 0.1 mL 0.19 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Naveri (1995) The role of angiotensin receptor subtypes in cerebrovascular regulation in the rat. Acta.Physiol.Scand.Suppl. 630 1 PMID: 8610501

Hakam and Hussain (2006) Angiotensin II AT2 receptors inhibit proximal tubular Na+-K+-ATPase activity via a NO/cGMP-dependent pathway. Am.J.Physiol.Renal Physiol. 290 F1430 PMID: 16380464

Criscione et al (1990) Binding characteristics and vascular effects of various angiotensin II antagonists. J.Cardiovas.Pharmacol. 16 S56 PMID:


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Keywords: Selective high affinity AT2 ligands Receptors Angiotensin CGP42112 Angiotensin AT2 Receptors

3 Citations for CGP 42112

Citations are publications that use Tocris products. Selected citations for CGP 42112 include:

Raffai et al (2016) Angiotensin-(1-7) selectively induces relaxation and modulates endothelium-dependent dilation in mesenteric arteries of salt-fed rats Journal of Vascular Research 53 105 PMID: 27676088

Nostramo et al (2012) Regulation of angiotensin II type 2 receptor gene expression in the adrenal medulla by acute and repeated immobilization stress. Stroke 215 291 PMID: 22911895

Li et al (2012) Perinatal nicotine exposure increases vulnerability of hypoxic-ischemic brain injury in neonatal rats: role of angiotensin II receptors. BMC Cancer 43 2483 PMID: 22738920


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Literature in this Area

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Pathways for CGP 42112

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