Selective, high affinity angiotensin AT2 receptor ligand (Ki = 0.24 nM). Displays agonistic properties at proximal tubule AT2 receptors, causes Na+, K+-ATPase inhibition and sodium excretion. Antagonizes Ang-II induced contractions in rabbit aortic rings (IC50 = 1850 nM).
(Modifications: Tyr-1 = N-α-Nicotinoyl, Lys-2 = Lys-(N-α-Z-Arg))
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Naveri (1995) The role of angiotensin receptor subtypes in cerebrovascular regulation in the rat. Acta.Physiol.Scand.Suppl. 630 1 PMID: 8610501
Hakam and Hussain (2006) Angiotensin II AT2 receptors inhibit proximal tubular Na+-K+-ATPase activity via a NO/cGMP-dependent pathway. Am.J.Physiol.Renal Physiol. 290 F1430 PMID: 16380464
Criscione et al (1990) Binding characteristics and vascular effects of various angiotensin II antagonists. J.Cardiovas.Pharmacol. 16 S56
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Keywords: CGP 42112, CGP 42112 supplier, Selective, high, affinity, AT2, ligands, Receptors, Angiotensin, CGP42112, 2569, Tocris Bioscience
3 Citations for CGP 42112
Citations are publications that use Tocris products. Selected citations for CGP 42112 include:
Nostramo et al (2012) Regulation of angiotensin II type 2 receptor gene expression in the adrenal medulla by acute and repeated immobilization stress. Stroke 215 291 PMID: 22911895
Li et al (2012) Perinatal nicotine exposure increases vulnerability of hypoxic-ischemic brain injury in neonatal rats: role of angiotensin II receptors. BMC Cancer 43 2483 PMID: 22738920
Raffai et al (2016) Angiotensin-(1-7) selectively induces relaxation and modulates endothelium-dependent dilation in mesenteric arteries of salt-fed rats Journal of Vascular Research 53 105 PMID: 27676088
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