You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Highly potent and very selective non-peptide angiotensin AT1 receptor antagonist (IC50 values are 0.7 and > 10000 nM for AT1 and AT2 receptors respectively). Potently inhibits angiotensin II-induced contractions in isolated rabbit aorta (IC50 = 0.2 nM) and reduces blood pressure in hypertensive rats.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 547.05. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||3.66 mL||18.28 mL||36.56 mL|
|2.5 mM||0.73 mL||3.66 mL||7.31 mL|
|5 mM||0.37 mL||1.83 mL||3.66 mL|
|25 mM||0.07 mL||0.37 mL||0.73 mL|
References are publications that support the biological activity of the product.
Mederski et al (1994) Non-peptide angiotensin II receptor antagonists: synthesis and biological activity of a series of novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridine derivatives. J.Med.Chem. 37 1632 PMID: 8201597
Mederski et al (1995) 4,5-Dihydro-4-oxo-3H-imidazo[4,5-c]pyridines: potent arylacetic acid-derived AT1 antagonists with improved affinity for the AT2 receptor. Bioorg.Med.Chem.Lett. 5 2665
If you know of a relevant reference for EMD 66684, please let us know.
View Related Products by Product Action
Keywords: EMD 66684, EMD 66684 supplier, Potent, selective, non-peptide, AT1, antagonists, Receptors, Angiotensin, EMD66684, 1849, Tocris Bioscience
Citations for EMD 66684
Citations are publications that use Tocris products.
Currently there are no citations for EMD 66684. Do you know of a great paper that uses EMD 66684 from Tocris? Please let us know.
Reviews for EMD 66684
There are currently no reviews for this product. Be the first to review EMD 66684 and earn rewards!
Have you used EMD 66684?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.