NF-κB Signaling Pathway

Nuclear factor kappa B signaling plays an important role in inflammation and the immune and stress responses. Adaptor proteins recruit the IKK complex which phosphorylates and degrades IκB, allowing NF-κB to translocate to the nucleus. Dysregulation of NF-κB signaling can lead to inflammatory and autoimmune disease and cancer.

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Signaling Pathway Key

Stimulates

Inhibits

Multistep Activation

Translocates

Kinase

Transcription Factor

Enzyme-linked Receptor

Other Protein

Nuclear Receptor