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6-Bnz-cAMP sodium salt
Cell permeable cAMP analog; selectively activates cAMP-dependent PKA but not Epac signaling pathways. Acts synergistically with 8-CPT-2Me-cAMP (Cat. No. 1645) to inhibit vascular smooth muscle cell proliferation.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 455.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.2 mL||10.98 mL||21.96 mL|
|5 mM||0.44 mL||2.2 mL||4.39 mL|
|10 mM||0.22 mL||1.1 mL||2.2 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
References are publications that support the biological activity of the product.
Hewer et al (2011) PKA and Epac synergistically inhibit smooth muscle cell proliferation. J.Mol.Cell Cardiol. 50 87 PMID: 20971121
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Keywords: 6-Bnz-cAMP sodium salt, 6-Bnz-cAMP sodium salt supplier, Cell, permeable, cAMP, analog, PKA, Epac, vascular, smooth, muscle, cell, VSMC, 5255, Tocris Bioscience
2 Citations for 6-Bnz-cAMP sodium salt
Citations are publications that use Tocris products. Selected citations for 6-Bnz-cAMP sodium salt include:
Mishra et al (2018) Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming TAX Resistance in ER-positive Breast Cancer. Clin Cancer Res 24 1987 PMID: 29386221
Mayati et al (2018) Functional polarization of human hepatoma HepaRG cells in response to forskolin. Sci Rep 8 16115 PMID: 30382126
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