6-Bnz-cAMP sodium salt

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Description: Cell permeable cAMP analog
Chemical Name: N-Benzoyladenosine cyclic 3',5'-(hydrogen phosphate) monosodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (6)
Reviews

Biological Activity for 6-Bnz-cAMP sodium salt

6-Bnz-cAMP sodium salt is a cell permeable cAMP analog; selectively activates cAMP-dependent PKA but not Epac signaling pathways. Acts synergistically with 8-CPT-2Me-cAMP (Cat. No. 1645) to inhibit vascular smooth muscle cell proliferation.

Technical Data for 6-Bnz-cAMP sodium salt

M. Wt 455.29
Formula C17H15N5NaO7P
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1135306-29-4
PubChem ID 23672707
InChI Key SPYGSKQRPXISIB-FKVBDRBCSA-M
Smiles [H][C@@]([C@@](O[C@@H](N3C=NC4=C3N=CN=C4NC(C5=CC=CC=C5)=O)[C@@H]2O)([H])CO1)2OP1(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 6-Bnz-cAMP sodium salt

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 45.53 100

Preparing Stock Solutions for 6-Bnz-cAMP sodium salt

The following data is based on the product molecular weight 455.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.2 mL 10.98 mL 21.96 mL
5 mM 0.44 mL 2.2 mL 4.39 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets for 6-Bnz-cAMP sodium salt

Certificate of Analysis / Product Datasheet
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References for 6-Bnz-cAMP sodium salt

References are publications that support the biological activity of the product.

Hewer et al (2011) PKA and Epac synergistically inhibit smooth muscle cell proliferation. J.Mol.Cell Cardiol. 50 87 PMID: 20971121


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Keywords: 6-Bnz-cAMP sodium salt, 6-Bnz-cAMP sodium salt supplier, Cell, permeable, cAMP, analog, PKA, Epac, vascular, smooth, muscle, cell, VSMC, 5255, Tocris Bioscience

6 Citations for 6-Bnz-cAMP sodium salt

Citations are publications that use Tocris products. Selected citations for 6-Bnz-cAMP sodium salt include:

Marco et al (2021) A PGE2-MEF2A axis enables context-dependent control of inflammatory gene expression. Immunity 54 1665-1682.e14 PMID: 34129840

Caglar et al (2019) Adenosine Receptor Signaling Targets Both PKA and Epac Pathways to Polarize Dendritic Cells to a Suppressive Phenotype. J Immunol 203 3247-3255 PMID: 31722989

Mayati et al (2018) Functional polarization of human hepatoma HepaRG cells in response to forskolin. Sci Rep 8 16115 PMID: 30382126

Mishra et al (2018) Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming TAX Resistance in ER-positive Breast Cancer. Clin Cancer Res 24 1987 PMID: 29386221


Do you know of a great paper that uses 6-Bnz-cAMP sodium salt from Tocris? Please let us know.

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