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6-Bnz-cAMP sodium salt
Biological Activity for 6-Bnz-cAMP sodium salt
6-Bnz-cAMP sodium salt is a cell permeable cAMP analog; selectively activates cAMP-dependent PKA but not Epac signaling pathways. Acts synergistically with 8-CPT-2Me-cAMP (Cat. No. 1645) to inhibit vascular smooth muscle cell proliferation.
Technical Data for 6-Bnz-cAMP sodium salt
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 6-Bnz-cAMP sodium salt
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for 6-Bnz-cAMP sodium salt
The following data is based on the product molecular weight 455.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.2 mL||10.98 mL||21.96 mL|
|5 mM||0.44 mL||2.2 mL||4.39 mL|
|10 mM||0.22 mL||1.1 mL||2.2 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
Product Datasheets for 6-Bnz-cAMP sodium salt
References for 6-Bnz-cAMP sodium salt
References are publications that support the biological activity of the product.
Hewer et al (2011) PKA and Epac synergistically inhibit smooth muscle cell proliferation. J.Mol.Cell Cardiol. 50 87 PMID: 20971121
If you know of a relevant reference for 6-Bnz-cAMP sodium salt, please let us know.
Keywords: 6-Bnz-cAMP sodium salt, 6-Bnz-cAMP sodium salt supplier, Cell, permeable, cAMP, analog, PKA, Epac, vascular, smooth, muscle, cell, VSMC, 5255, Tocris Bioscience
6 Citations for 6-Bnz-cAMP sodium salt
Citations are publications that use Tocris products. Selected citations for 6-Bnz-cAMP sodium salt include:
Mayati et al (2018) Functional polarization of human hepatoma HepaRG cells in response to forskolin. Sci Rep 8 16115 PMID: 30382126
Marco et al (2021) A PGE2-MEF2A axis enables context-dependent control of inflammatory gene expression. Immunity 54 1665-1682.e14 PMID: 34129840
Caglar et al (2019) Adenosine Receptor Signaling Targets Both PKA and Epac Pathways to Polarize Dendritic Cells to a Suppressive Phenotype. J Immunol 203 3247-3255 PMID: 31722989
Mishra et al (2018) Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming TAX Resistance in ER-positive Breast Cancer. Clin Cancer Res 24 1987 PMID: 29386221
Grant A et al (2020) Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis. EMBO J 39 e105111 PMID: 32945574
Jason P et al (2020) Osmotic Gradients in Epithelial Acini Increase Mechanical Tension across E-cadherin, Drive Morphogenesis, and Maintain Homeostasis. Curr Biol 30 624-633.e4 PMID: 31983640
Do you know of a great paper that uses 6-Bnz-cAMP sodium salt from Tocris? Please let us know.
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Literature in this Area
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