6-Bnz-cAMP sodium salt

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Cat.No. 5255 - 6-Bnz-cAMP sodium salt | C17H15N5NaO7P | CAS No. 1135306-29-4
Description: Cell permeable cAMP analog
Chemical Name: N6-Benzoyladenosine-3',5'-cyclic monophosphate sodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Cell permeable cAMP analog; selectively activates cAMP-dependent PKA but not Epac signaling pathways. Acts synergistically with 8-CPT-2Me-cAMP (Cat. No. 1645) to inhibit vascular smooth muscle cell proliferation.

Technical Data

M. Wt 455.29
Formula C17H15N5NaO7P
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1135306-29-4
PubChem ID 23672707
InChI Key SPYGSKQRPXISIB-FKVBDRBCSA-M
Smiles [H][C@@]([C@@](O[C@@H](N3C=NC4=C3N=CN=C4NC(C5=CC=CC=C5)=O)[C@@H]2O)([H])CO1)2OP1(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 45.53 100

Preparing Stock Solutions

The following data is based on the product molecular weight 455.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.2 mL 10.98 mL 21.96 mL
5 mM 0.44 mL 2.2 mL 4.39 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hewer et al (2011) PKA and Epac synergistically inhibit smooth muscle cell proliferation. J.Mol.Cell Cardiol. 50 87 PMID: 20971121


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Keywords: 6-Bnz-cAMP sodium salt, supplier, Cell, permeable, cAMP, analog, PKA, Epac, vascular, smooth, muscle, cell, VSMC, cAMP, cAMP, Tocris Bioscience

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