Bcl-2 Family Inhibitors

Cat. No. Product Name / Activity
6409 A 1210477
Selective, high affinity Mcl-1 inhibitor; proapoptotic
6960 ABT 199
Selective, high affinity Bcl-2 inhibitor; orally bioavailable
6835 ABT 737
Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines
4676 ARRY 520 trifluoroacetate
Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation
2160 Bax channel blocker
Allosteric inhibitor of Bax channel activation
1785 Bax inhibitor peptide V5
Inhibitor of Bax-mediated apoptosis
6323 FX 1
Bcl-6 inhibitor; 10-fold more potent than endogenous Bcl-6 corepressors
3590 Gambogic acid
Apoptosis inducer. Inhibits Bcl-2 family proteins
3794 iMAC2
Inhibitor of Bid-induced Bax cytochrome c release
4819 Methylprednisolone
Anti-apoptotic; upregulates expression of Bcl-xL after injury
4762 MIM1
Mcl-1 inhibitor; proapoptotic
5733 ML 311
Inhibits Mcl-1-BIM interaction
6539 Obatoclax mesylate
Inhibitor of Bcl-2 family members; antiapoptotic