Home / Cell Biology / Regulated Cell Death / Apoptosis / Bcl-2 Family / Bcl-2 Family Inhibitors

Bcl-2 Family Inhibitors

Cat. No. Product Name / Activity
7661 A 1331852
Potent and selective Bcl-xL inhibitor; antitumor and inducer of apoptosis
6960 ABT 199
Selective, high affinity Bcl-2 inhibitor; orally bioavailable
7680 ABT 263
High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor
6835 ABT 737
Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines
4676 ARRY 520 trifluoroacetate
Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation
2160 Bax channel blocker
Allosteric inhibitor of Bax channel activation
6323 FX 1
Bcl-6 inhibitor; 10-fold more potent than endogenous Bcl-6 corepressors
3794 iMAC2
Inhibitor of Bid-induced Bax cytochrome c release
4819 Methylprednisolone
Anti-apoptotic; upregulates expression of Bcl-xL after injury
5733 ML 311
Inhibits Mcl-1-BIM interaction
6539 Obatoclax mesylate
Inhibitor of Bcl-2 family members; antiapoptotic