Bcl-2 Family Inhibitors

Cat. No.	Product Name / Activity
6409	A 1210477
	Selective, high affinity Mcl-1 inhibitor; proapoptotic
7661	A 1331852 New
	Potent and selective Bcl-xL inhibitor; antitumor and inducer of apoptosis
6960	ABT 199
	Selective, high affinity Bcl-2 inhibitor; orally bioavailable
7680	ABT 263
	High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor
6835	ABT 737
	Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines
4676	ARRY 520 trifluoroacetate
	Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation
2160	Bax channel blocker
	Allosteric inhibitor of Bax channel activation
6323	FX 1
	Bcl-6 inhibitor; 10-fold more potent than endogenous Bcl-6 corepressors
3794	iMAC2
	Inhibitor of Bid-induced Bax cytochrome c release
4819	Methylprednisolone
	Anti-apoptotic; upregulates expression of Bcl-x_L after injury
5733	ML 311
	Inhibits Mcl-1-BIM interaction
6539	Obatoclax mesylate
	Inhibitor of Bcl-2 family members; antiapoptotic