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Bax channel blocker

Cat. No. 2160 2 Citations Submit a Review Datasheet / COA / SDS
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Cat.No. 2160 - Bax channel blocker | C19H21Br2N3O.2HCl | CAS No. 329349-20-4
Description: Allosteric inhibitor of Bax channel activation
Alternative Names: BAI1
Chemical Name: 3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (4)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Allosteric inhibitor of Bax channel activation. Binds inactive Bax at allosteric site and inhibits tBID-mediated Bax activation (IC50 = 3.3 μM). Selectively inhibits Bax-dependent apoptosis. Potent inhibitor of Bax-mediated mitochondrial cytochrome c release (IC50 = 0.52 μM).

Compound Libraries

Bax channel blocker is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 540.12
Formula C19H21Br2N3O.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 329349-20-4
PubChem ID 2729026
InChI Key HWFKCAFKXZFOQT-UHFFFAOYSA-N
Smiles Cl.Cl.OC(CN1C2=C(C=C(Br)C=C2)C2=C1C=CC(Br)=C2)CN1CCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 2.34 5
DMSO 46.72 100

Preparing Stock Solutions

The following data is based on the product molecular weight 540.12. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.85 mL 9.26 mL 18.51 mL
5 mM 0.37 mL 1.85 mL 3.7 mL
10 mM 0.19 mL 0.93 mL 1.85 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

Molarity Calculator

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Bombrun et al (2003) 3,6-Dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation. J.Med.Chem. 46 21

Garner et al (2019) Small-molecule allosteric inhibitors of BAX. Nat.Chem.Biol. 15 322 PMID: 30718816

If you know of a relevant reference for Bax channel blocker, please let us know.

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Keywords: Bax channel blocker, Bax channel blocker supplier, inhibitors, inhibits, Bax-mediated, mitochondrial, cytochrome, c, release, Bcl-2, Family, allosteric, activation, BAI1, 2160, Tocris Bioscience

2 Citations for Bax channel blocker

Citations are publications that use Tocris products. Selected citations for Bax channel blocker include:

Ono et al (2017) Feedback activation of AMPK-mediated autophagy acceleration is a key resistance mechanism against SCD1 inhibitor-induced cell growth inhibition. PLoS One 12 e0181243 PMID: 28704514

Sano et al (2016) Vacuolin-1 inhibits autophagy by impairing lysosomal maturation via PIKfyve inhibition. FEBS Lett 590 1576 PMID: 27135648

Do you know of a great paper that uses Bax channel blocker from Tocris? Please let us know.

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Literature in this Area

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Pathways for Bax channel blocker

Apoptosis

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Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.