Bax channel blocker

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Cat.No. 2160 - Bax channel blocker | C19H21Br2N3O.2HCl | CAS No. 329349-20-4
Description: Inhibits Bax-mediated mitochondrial cytochrome c release
Chemical Name: 3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature
Pathways

Biological Activity

Potent inhibitor of Bax-mediated mitochondrial cytochrome c release (IC50 = 0.52 μM). Suggested to inhibit Bax channel formation/activity.

Compound Libraries

Bax channel blocker is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 540.12
Formula C19H21Br2N3O.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 329349-20-4
PubChem ID 2729026
InChI Key HWFKCAFKXZFOQT-UHFFFAOYSA-N
Smiles Cl.Cl.OC(CN1C2=C(C=C(Br)C=C2)C2=C1C=CC(Br)=C2)CN1CCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.72 100
water 2.34 5

Preparing Stock Solutions

The following data is based on the product molecular weight 540.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.85 mL 9.26 mL 18.51 mL
5 mM 0.37 mL 1.85 mL 3.7 mL
10 mM 0.19 mL 0.93 mL 1.85 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Bombrun et al (2003) 3,6-Dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation. J.Med.Chem. 46 21


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Keywords: Bax channel blocker, Bax channel blocker supplier, inhibitors, inhibits, Bax-mediated, mitochondrial, cytochrome, c, release, Bcl-2, Family, 2160, Tocris Bioscience

1 Citation for Bax channel blocker

Citations are publications that use Tocris products. Selected citations for Bax channel blocker include:

Ono et al (2017) Feedback activation of AMPK-mediated autophagy acceleration is a key resistance mechanism against SCD1 inhibitor-induced cell growth inhibition. PLoS One 12 e0181243 PMID: 28704514


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Literature in this Area

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Pathways for Bax channel blocker

Apoptosis

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