Bax channel blocker
Biological Activity
Potent inhibitor of Bax-mediated mitochondrial cytochrome c release (IC50 = 0.52 μM). Suggested to inhibit Bax channel formation/activity.
Compound Libraries
Bax channel blocker is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
M. Wt | 540.12 |
Formula | C19H21Br2N3O.2HCl |
Storage | Desiccate at RT |
Purity | ≥98% (HPLC) |
CAS Number | 329349-20-4 |
PubChem ID | 2729026 |
InChI Key | HWFKCAFKXZFOQT-UHFFFAOYSA-N |
Smiles | Cl.Cl.OC(CN1C2=C(C=C(Br)C=C2)C2=C1C=CC(Br)=C2)CN1CCNCC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 46.72 | 100 | |
water | 2.34 | 5 |
Preparing Stock Solutions
The following data is based on the product molecular weight 540.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.85 mL | 9.26 mL | 18.51 mL |
5 mM | 0.37 mL | 1.85 mL | 3.7 mL |
10 mM | 0.19 mL | 0.93 mL | 1.85 mL |
50 mM | 0.04 mL | 0.19 mL | 0.37 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Bombrun et al (2003) 3,6-Dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation. J.Med.Chem. 46 21 PMID:
If you know of a relevant reference for Bax channel blocker, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Bax channel blocker, supplier, inhibitors, inhibits, Bax-mediated, mitochondrial, cytochrome, c, release, Bcl-2, Family, Bcl-2, Family, Bcl-2, Family, Tocris Bioscience
1 Citation for Bax channel blocker
Citations are publications that use Tocris products. Selected citations for Bax channel blocker include:
Ono et al (2017) Feedback activation of AMPK-mediated autophagy acceleration is a key resistance mechanism against SCD1 inhibitor-induced cell growth inhibition. PLoS One 12 e0181243 PMID: 28704514
Do you know of a great paper that uses Bax channel blocker from Tocris? If so please let us know.
Reviews for Bax channel blocker
There are currently no reviews for this product. Be the first to review Bax channel blocker and earn rewards!
Have you used Bax channel blocker?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and Europe
Submit a ReviewLiterature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Parkinson's Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.