CCT 369260

Pricing Availability   Qty
Description: Molecular glue; induces degradation of BCL6
Chemical Name: rel-5-[[5-Chloro-2-[(3R,5S)-4,4-difluoro-3,5-dimethyl-1-piperidinyl]-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl-2H-benzimidazol-2-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity for CCT 369260

CCT 369260 acts as a potent BCL6 molecular glue Degrader (IC50 = 54 nM). It reduces BCL6 levels in a lymphoma xenograft mouse model. CCT 369260 is orally bioavailable.

Technical Data for CCT 369260

M. Wt 509
Formula C24H31ClF2N6O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2253878-44-1
PubChem ID 135386938
InChI Key VFNPUAOAEFMXQI-GASCZTMLSA-N
Smiles CC(C)(O)CCN1C2=CC(NC3=NC(N4C[C@@H](C(F)([C@@H](C4)C)F)C)=NC=C3Cl)=CC=C2N(C1=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CCT 369260

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.45 50

Preparing Stock Solutions for CCT 369260

The following data is based on the product molecular weight 509. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.93 mL 19.65 mL 39.29 mL
2.5 mM 0.79 mL 3.93 mL 7.86 mL
5 mM 0.39 mL 1.96 mL 3.93 mL
25 mM 0.08 mL 0.39 mL 0.79 mL

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References for CCT 369260

References are publications that support the biological activity of the product.

Bellenie et al (2020) Achieving in vivo target depletion through the discovery and optimization of Benzimidazolone BCL6 degraders. J.Med.Chem. 2020 63 PMID: 32275432


If you know of a relevant reference for CCT 369260, please let us know.

Keywords: CCT 369260, CCT 369260 supplier, CCT369260, molecular, glue, proteasomal, degraders, inhibitors, inhibit, inhibition, BCL6, ubiquitination, orally, bioavailable, in, vivo, Molecular, Glues, Bcl-2, Family, 7799, Tocris Bioscience

Citations for CCT 369260

Citations are publications that use Tocris products.

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Literature in this Area

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