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Submit ReviewEndothelin 1 (human, porcine)
Description: Potent vasoconstrictor peptide
Alternative Names: ET-1
Purity: ≥95% (HPLC)
Biological Activity for Endothelin 1 (human, porcine)
Endothelin 1 (human, porcine) is an endogenous potent vasoconstrictor peptide that is an agonist at ETA and ETB receptors. Modulates vascular tone.
Technical Data for Endothelin 1 (human, porcine)
| M. Wt | 2492 |
| Formula | C109H159O32N25S5 |
| Sequence |
CSCSSLMDKECVYFCHLDIIW (Modifications: Disulfide bridges 1-15, 3-11) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 117399-94-7 |
| PubChem ID | 16133807 |
| InChI Key | ZUBDGKVDJUIMQQ-ZTNLKOGPSA-N |
| Smiles | [H][C@](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@]2([H])CSSC[C@]([H])(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=CC=C(O)C=C2)C(=O)N[C@H](CC2=CC=CC=C2)C(=O)N1)([C@@H](C)CC)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Endothelin 1 (human, porcine)
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for Endothelin 1 (human, porcine)
References for Endothelin 1 (human, porcine)
References are publications that support the biological activity of the product.
Inoue et al (1989) The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc.Natl.Acad.Sci.U.S.A. 86 2863 PMID: 2649896
Servitja et al (1998) Involvement of ETA and ETB receptors in the activation of phospholipase D by endothelins in cultured rat cortical astrocytes. Br.J.Pharmacol. 124 1728 PMID: 9756390
Yanagisawa et al (1988) Primary structure, synthesis, and biological activity of rat endothelin, and endothelium-derived vasoconstrictor peptide. Proc.Natl.Acad.Sci.U.S.A. 85 6964 PMID: 3045827
Yanagisawa and Masaski (1989) Molecular biology and biochemistry of the endothelins. TiPS 10 374 PMID: 2690429
If you know of a relevant reference for Endothelin 1 (human, porcine), please let us know.
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Keywords: Endothelin 1 (human, porcine), Endothelin 1 (human, porcine) supplier, Potent, vasoconstrictor, peptide, Endothelin, Non-Selective, ET, Receptors, agonists, Endothelin1, (human, porcine), ET-1, Non-selective, 1160, Tocris Bioscience
16 Citations for Endothelin 1 (human, porcine)
Citations are publications that use Tocris products. Selected citations for Endothelin 1 (human, porcine) include:
Khan et al (2006) Pharmacological characterization of endothelin receptors-mediated contraction in the mouse isolated proximal and distal colon. Br J Pharmacol 147 607 PMID: 16432510
Giachini et al (2009) Interleukin-10 attenuates vascular responses to endothelin-1 via effects on ERK1/2-dependent pathway. Am J Physiol Heart Circ Physiol 296 H489 PMID: 19074677
McQueen et al (2007) Endothelin-1 activates ETA receptors to cause reflex scratching in BALB/c mice. Br J Pharmacol 151 278 PMID: 17351652
Zheng et al (2017) Gastrodin Inhibits Store-Operated Ca(2+) Entry and Alleviates Cardiac Hypertrophy. Front Pharmacol 8 222 PMID: 28487655
Yuan et al (2015) Endothelial cells enhance the migration of bovine meniscus cells. J Neurosci 67 182 PMID: 25307081
Schafer et al (2017) IL-11 is a crucial determinant of cardiovascular fibrosis. Nature 552 110 PMID: 29160304
Ban et al (2019) S-nitrosation impairs KLF4 activity and instigates endothelial dysfunction in pulmonary arterial hypertension. Redox Biol 21 101099 PMID: 30660098
Suri et al (2010) Quercetin and its major metabolites selectively modulate cyclic GMP-dependent relaxations and associated tolerance in pig isolated coronary artery. Br J Pharmacol 159 566 PMID: 20050852
Cheng et al (2019) The role of Nav1.7 and methylglyoxal-mediated activation of TRPA1 in itch and hypoalgesia in a murine model of type 1 diabetes. Theranostics 9 4287 PMID: 31285762
Yuan et al (2018) Dynamics and Functional Role of Dopaminergic Neurons in the Ventral Tegmental Area during Itch Processing. J Neurosci 38 9856 PMID: 30266741
Zhuang et al (2018) Fasudil preserves lung endothelial function and reduces pulmonary vascular remodeling in a rat model of end-stage pulmonary hypertension with left heart disease. Int J Mol Med 42 1341 PMID: 29901088
Cirino et al (2003) Involvement of β 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function. Arthritis Rheumatol 100 5531 PMID: 12707413
Needham et al (2014) The role of K+ and Cl- channels in the regulation of retinal arteriolar tone and blood flow. J Pharmacol Exp Ther 55 2157 PMID: 24609622
Hamby et al (2012) Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. Invest Ophthalmol Vis Sci 32 14489 PMID: 23077035
Bellono et al (2014) UV light activates a Gαq/11-coupled phototransduction pathway in human melanocytes. J Gen Physiol 143 203 PMID: 24470488
Sánchez et al (2014) Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from Ins-resistant obese rats: role of ET(A) and ET(B) receptors. Br J Pharmacol 171 5682 PMID: 25091502
Do you know of a great paper that uses Endothelin 1 (human, porcine) from Tocris? Please let us know.
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