5-HT2A and α1 adrenoceptor antagonist. Enhances neuronal differentiation of mouse and human neural progenitor cells. Also inhibits PERK/eIF2α-P-mediated reduction in protein synthesis and restores memory deficits in a mouse dementia model. Antidepressant and neuroprotectant.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 408.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.45 mL||12.25 mL||24.49 mL|
|5 mM||0.49 mL||2.45 mL||4.9 mL|
|10 mM||0.24 mL||1.22 mL||2.45 mL|
|50 mM||0.05 mL||0.24 mL||0.49 mL|
References are publications that support the products' biological activity.
Bortolotto et al (2017) Proneurogenic effects of trazodone in murine and human neural progenitor cells. ACS Chem.Neurosci. PMID: 28636360
Halliday et al (2017) Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice. Brain 140 1768 PMID: 28430857
If you know of a relevant reference for Trazodone hydrochloride, please let us know.
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