Trazodone hydrochloride

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Cat.No. 6336 - Trazodone hydrochloride | C19H22ClN5O.HCl | CAS No. 25332-39-2
Description: 5-HT2A and α1 adrenoceptor antagonist; also enhances neural differentiation; antidepressant and neuroprotectant
Chemical Name: 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

5-HT2A and α1 adrenoceptor antagonist. Enhances neuronal differentiation of mouse and human neural progenitor cells. Also inhibits PERK/eIF2α-P-mediated reduction in protein synthesis and restores memory deficits in a mouse dementia model. Antidepressant and neuroprotectant.

Technical Data

M. Wt 408.32
Formula C19H22ClN5O.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 25332-39-2
PubChem ID 62935
InChI Key OHHDIOKRWWOXMT-UHFFFAOYSA-N
Smiles ClC1=CC=CC(N2CCN(CC2)CCCN3N=C4C=CC=CN4C3=O)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 8.17 20
DMSO 20.42 50

Preparing Stock Solutions

The following data is based on the product molecular weight 408.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.9 mL 24.49 mL 48.98 mL
2.5 mM 0.98 mL 4.9 mL 9.8 mL
5 mM 0.49 mL 2.45 mL 4.9 mL
25 mM 0.1 mL 0.49 mL 0.98 mL

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References

References are publications that support the biological activity of the product.

Bortolotto et al (2017) Proneurogenic effects of trazodone in murine and human neural progenitor cells. ACS Chem.Neurosci. 8 2027 PMID: 28636360

Halliday et al (2017) Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice. Brain 140 1768 PMID: 28430857


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Citations for Trazodone hydrochloride

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Literature in this Area

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