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Cat.No. 6048 - R-BC154 | C55H61N9O13S3.CH3CO2H
Description: High affinity fluorescent α4β1/α9β1 inhibitor; mobilizes HSCs
Chemical Name: (4R)-4-[4-[[[[4-[3,6-Bis(diethylamino)xanthylium-9-yl]-3-sulfophenyl]sulfonyl]amino]methyl]-1H-1,2,3-triazol-1-yl]-1-(phenylsulfonyl)-L-prolyl-O-(1-pyrrolidinyl)-L-tyrosine acetate
Purity: ≥97% (HPLC)
Literature (3)

Biological Activity

High affinity fluorescent α4β1/α9β1 inhibitor (Kd values are 12.7 and 38 nM, respectively); fluorescent version of BOP (Cat.No. 6047). Rapidly and preferentially mobilizes HSCs and progenitors in vivo. Excitation maximum, 561 nm; emissiosn maximum, 585 nm.

Technical Data

M. Wt 1212.37
Formula C55H61N9O13S3.CH3CO2H
Storage Store at -20°C
Purity ≥97% (HPLC)
PubChem ID 131648245
Smiles CCN(C1=CC2=[O+]C3=C(C(C4=C(S([O-])(=O)=O)C=C(S(=O)(NCC5=CN([C@@H]6C[C@@H](C(N[C@H](C(O)=O)CC7=CC=C(C=C7)OC(N8CCCC8)=O)=O)N(S(=O)(C9=CC=CC=C9)=O)C6)N=N5)=O)C=C4)=C2C=C1)C=CC(N(CC)CC)=C3)CC.CC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 6.06 5

Preparing Stock Solutions

The following data is based on the product molecular weight 1212.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 16.5 mL 82.48 mL 164.97 mL
0.25 mM 3.3 mL 16.5 mL 32.99 mL
0.5 mM 1.65 mL 8.25 mL 16.5 mL
2.5 mM 0.33 mL 1.65 mL 3.3 mL

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References are publications that support the biological activity of the product.

Cao et al (2014) Design, synthesis and binding properties of a fluorescent α9β1/α4β1 integrin antagonist and its application as an in vi Org.Biomol.Chem. 12 965 PMID: 24363056

Cao et al (2016) Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist. Nat.Commun. 7 11007 PMID: 26975966

If you know of a relevant reference for R-BC154, please let us know.

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Keywords: R-BC154, R-BC154 supplier, dual, a9b1/a4b1, integrin, inhibitor;, rapidly, mobilizes, HSCs, progenitors, high, affinity, fluorescent, BOP, hematopoietic, stem, cell, alpha9beta1/alpha4beta1, Integrins, Cell, Adhesion, Molecules, Stem, Signaling, 6048, Tocris Bioscience

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Angiogenesis in Cancer Poster

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Enabling Research By Provision of Chemical Tools

Enabling Research By Provision of Chemical Tools Poster

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.