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Biological Activity for R-BC154
R-BC154 is a high affinity fluorescent α4β1/α9β1 inhibitor (Kd values are 12.7 and 38 nM, respectively); fluorescent version of BOP (Cat.No. 6047). Rapidly and preferentially mobilizes HSCs and progenitors in vivo. Excitation maximum, 561 nm; emissiosn maximum, 585 nm.
Technical Data for R-BC154
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for R-BC154
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for R-BC154
The following data is based on the product molecular weight 1212.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.05 mM||16.5 mL||82.48 mL||164.97 mL|
|0.25 mM||3.3 mL||16.5 mL||32.99 mL|
|0.5 mM||1.65 mL||8.25 mL||16.5 mL|
|2.5 mM||0.33 mL||1.65 mL||3.3 mL|
References for R-BC154
References are publications that support the biological activity of the product.
Cao et al (2014) Design, synthesis and binding properties of a fluorescent α9β1/α4β1 integrin antagonist and its application as an in vivo probe for bone marrow haemopoietic stem cells. Org.Biomol.Chem. 12 965 PMID: 24363056
Cao et al (2016) Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist. Nat.Commun. 7 11007 PMID: 26975966
If you know of a relevant reference for R-BC154, please let us know.
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Citations for R-BC154
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Literature in this Area
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Fluorescent Dyes and Probes Research Product GuideUpdated
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