R-BC154

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Cat.No. 6048 - R-BC154 | C55H61N9O13S3.CH3CO2H
Description: High affinity fluorescent α4β1/α9β1 inhibitor; mobilizes HSCs
Chemical Name: (4R)-4-[4-[[[[4-[3,6-Bis(diethylamino)xanthylium-9-yl]-3-sulfophenyl]sulfonyl]amino]methyl]-1H-1,2,3-triazol-1-yl]-1-(phenylsulfonyl)-L-prolyl-O-(1-pyrrolidinyl)-L-tyrosine acetate
Purity: ≥97% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity fluorescent α4β1/α9β1 inhibitor (Kd values are 12.7 and 38 nM, respectively); fluorescent version of BOP (Cat.No. 6047). Rapidly and preferentially mobilizes HSCs and progenitors in vivo.

Technical Data

M. Wt 1212.37
Formula C55H61N9O13S3.CH3CO2H
Storage Store at -20°C
Purity ≥97% (HPLC)
Smiles CCN(C1=CC2=[O+]C3=C(C(C4=C(S([O-])(=O)=O)C=C(S(=O)(NCC5=CN([C@@H]6C[C@@H](C(N[C@H](C(O)=O)CC7=CC=C(C=C7)OC(N8CCCC8)=O)=O)N(S(=O)(C9=CC=CC=C9)=O)C6)N=N5)=O)C=C4)=C2C=C1)C=CC(N(CC)CC)=C3)CC.CC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.06 5

Preparing Stock Solutions

The following data is based on the product molecular weight 1212.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.82 mL 4.12 mL 8.25 mL
5 mM 0.16 mL 0.82 mL 1.65 mL
10 mM 0.08 mL 0.41 mL 0.82 mL
50 mM 0.02 mL 0.08 mL 0.16 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Cao et al (2014) Design, synthesis and binding properties of a fluorescent α9β1/α4β1 integrin antagonist and its application as an in vi Org.Biomol.Chem. 12 965 PMID: 24363056

Cao et al (2016) Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist. Nat.Commun. 7 11007 PMID: 26975966


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Keywords: R-BC154, supplier, dual, a9b1/a4b1, integrin, inhibitor;, rapidly, mobilizes, HSCs, progenitors, high, affinity, fluorescent, BOP, hematopoietic, stem, cell, alpha9beta1/alpha4beta1, Integrins, Cell, Adhesion, Molecules, Stem, Cell, Signaling, Integrins, Tocris Bioscience

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