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Biological Activity for ProTx I
ProTx I is a selective CaV3.1 channel blocker (IC50 values are 0.2 and 31.8 μM for hCaV3.1 and hCaV3.2 respectively). Also reversibly inhibits NaV1.8 and blocks KV2.1 channels.
Technical Data for ProTx I
(Modifications: Disulfide bridge: 2-16, 9-21, 15-28)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ProTx I
|Solubility||Soluble to 2 mg/ml in water|
References for ProTx I
References are publications that support the biological activity of the product.
Ohkubo et al (2010) Tarantula toxin ProTx-I differentiates between human T-type voltage-gated Ca2+ channels Cav3.1 and Cav3.2. J.Pharmacol.Sci. 112 452 PMID: 20351484
Ohkubo and Yamazaki (2012) T-type voltage-activated calcium channel Cav3.1, but not Cav3.2, is involved in the inhibition of proliferation and apoptosis in MCF-7 human breast cancer cells. Int.J.Oncol. 41 267 PMID: 22469755
Middleton et al (2002) Two tarantula peptides inhibit activation of multiple sodium channels. Biochemistry 41 14734 PMID: 12475222
If you know of a relevant reference for ProTx I, please let us know.
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Citations for ProTx I
Citations are publications that use Tocris products.
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Reviews for ProTx I
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.