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Jervine

Cat. No. 4717 COA / Product Datasheet SDS
Pricing Availability Delivery Time Qty
Cat.No. 4717 - Jervine | C27H39NO3 | CAS No. 469-59-0
Description: Inhibitor of Hedgehog (Hh) signaling; binds directly to Smo
Chemical Name: (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Biological Activity Technical Data Solubility Calculators Datasheets

Biological Activity

Inhibitor of Hedgehog signaling (IC50 = 500 - 700 nM); binds directly to Smoothened (Smo). Inhibits the response of target tissues to Sonic hedgehog signaling, possibly via the sterol sensing domain of Patched. Teratogenic.

Technical Data

M. Wt 425.6
Formula C27H39NO3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 469-59-0
PubChem ID 10098
InChI Key CLEXYFLHGFJONT-DNMILWOZSA-N
Smiles O[C@H](C2)CC[C@@]1(C)C2=CC[C@]([C@@](CC[C@@]54O[C@@](C[C@H](C)CN6)([H])[C@]6([H])[C@H]5C)([H])C3=[C@@]4C)([H])[C@@]([H])1C3=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.51 20
ethanol 21.28 50

Preparing Stock Solutions

The following data is based on the product molecular weight 425.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.35 mL 11.75 mL 23.5 mL
5 mM 0.47 mL 2.35 mL 4.7 mL
10 mM 0.23 mL 1.17 mL 2.35 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
Safety Datasheet

References

References are publications that support the products' biological activity.

Cooper et al (1998) Teratogen-mediated inhibition of target tissue response to Shh signaling. Science 280 1603 PMID: 9616123

Williams et al (2003) Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions. Proc.Natl.Acad.Sci.USA 100 4616 PMID: 12679522

ten Berge et al (2001) Prx1 and Prx2 are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis. Development 128 2929 PMID: 11532916

If you know of a relevant reference for Jervine, please let us know.

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Keywords: Jervine teratogens teratogenic Smoothened Smo antagonists Hedgehog signaling signalling inhibitors inhibits Hedgehog Signaling

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