Jervine

Discontinued Product

4717 has been discontinued.

View all Hedgehog Signaling products.
Description: Inhibitor of Hedgehog (Hh) signaling; binds directly to Smo
Chemical Name: (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity for Jervine

Jervine is an inhibitor of Hedgehog signaling (IC50 = 500 - 700 nM); binds directly to Smoothened (Smo). Inhibits the response of target tissues to Sonic hedgehog signaling, possibly via the sterol sensing domain of Patched. Teratogenic.

Technical Data for Jervine

M. Wt 425.6
Formula C27H39NO3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 469-59-0
PubChem ID 10098
InChI Key CLEXYFLHGFJONT-DNMILWOZSA-N
Smiles O[C@H](C2)CC[C@@]1(C)C2=CC[C@]([C@@](CC[C@@]54O[C@@](C[C@H](C)CN6)([H])[C@]6([H])[C@H]5C)([H])C3=[C@@]4C)([H])[C@@]([H])1C3=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Jervine

References are publications that support the biological activity of the product.

Cooper et al (1998) Teratogen-mediated inhibition of target tissue response to Shh signaling. Science 280 1603 PMID: 9616123

Williams et al (2003) Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions. Proc.Natl.Acad.Sci.USA 100 4616 PMID: 12679522

ten Berge et al (2001) Prx1 and Prx2 are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis. Development 128 2929 PMID: 11532916

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Keywords: Jervine, Jervine supplier, Jervine, teratogens, teratogenic, Smoothened, Smo, antagonists, Hedgehog, signaling, signalling, inhibitors, inhibits, Receptors, Signaling, 4717, Tocris Bioscience

Citations for Jervine

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Currently there are no citations for Jervine.

Reviews for Jervine

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Literature in this Area

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