H+-ATPase

H+-ATPase (also known as vacuolar ATPase, V-ATPase) is a enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes and endosomes.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
1334 Bafilomycin A1
H+-ATPase (vacuolar) inhibitor
2656 Concanamycin A
H+-ATPase (vacuolar) inhibitor
3807 Disulfiram
Inhibitor of V-ATPase; displays a range of other activities

Related Targets

    H+-ATPase (also known as vacuolar ATPase, V-ATPase) is an enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes, the Golgi apparatus, chromaffin granules and coated vesicles, as well as in the plasma membrane.

    H+-ATPase is a multisubunit complex composed of two domains. The V1 domain is responsible for ATP hydrolysis and the V0 domain is responsible for protein translocation. There are two main mechanisms of regulating H+-ATPase activity; recycling of H+-ATPase-containing vesicles to and from the plasma membrane and glucose-sensitive assembly/disassembly of the holoenzyme complex.

    These transporters play an important role in processes such as receptor-mediated endocytosis, protein degradation and coupled transport. They have a function in bone reabsorption and mutations in the A3 gene cause recessive osteopetrosis. Furthermore, H+-ATPases have been implicated in tumor metastasis and regulation of sperm motility and maturation.

    Literature for H+-ATPase

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    • 7-TM Receptors
    • Enzymes
    • Enzyme-Linked Receptors
    • Ion Channels
    • Nuclear Receptors
    • Transporters
    • Apoptosis
    • Cell Metabolism
    • Epigenetics
    • Fluorescent Imaging
    • Signal Transduction
    • Stem Cells

    H+-ATPase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    ATP6V1A Human ATP6V1A NM_001690 P38606
    Mouse Atp6v1a NM_007508 P50516
    Rat Atp6v1a NM_001108318 NP_001101788
    ATP6V1B1 Human ATP6V1B1 NM_001692 P15313
    Mouse Atp6v1b1 NM_134157 NP_598918
    Rat Atp6v1b1 NM_001107867 XP_232119
    ATP6V1B2 Human ATP6V1B2 NM_001693 P21281
    Mouse Atp6v1b2 NM_007509 P62814
    Rat Atp6v1b2 NM_057213 P62815
    ATP6V1C1 Human ATP6V1C1 NM_001695 P21283
    Mouse Atp6v1c1 NM_025494 Q9Z1G3
    Rat Atp6v1c1 NM_001011992 Q5FVI6
    ATP6V1C2 Human ATP6V1C2 NM_144583 Q8NEY4
    Mouse Atp6v1c2 NM_133699 Q99L60
    Rat Atp6v1c2 NM_001014199 Q6AYE4
    ATP6V1D Human ATP6V1D NM_015994 Q9Y5K8
    Mouse Atp6v1d NM_023721 P57746
    Rat Atp6v1d NM_199386 Q6P503
    ATP6V1E1 Human ATP6V1E1 NM_001696 P36543
    Mouse Atp6v1e1 NM_007510 P50518
    Rat Atp6v1e1 NM_198745 Q6PCU2
    ATP6V1E2 Human ATP6V1E2 NM_080653 Q96A05
    Mouse Atp6v1e2 NM_029121 Q9D593
    Rat Atp6v1e2 NM_001108979 XP_345633
    ATP6V1F Human ATP6V1F NM_004231 P06576
    Mouse Atp6v1f NM_025381 Q9D1K2
    Rat Atp6v1f NM_053884 P50408
    ATP6V1G1 Human ATP6V1G1 NM_004888 O75348
    Mouse Atp6v1g1 NM_024173 Q9CR51
    Rat Atp6v1g1 NM_001106660 XP_216411
    ATP6V1G2 Human ATP6V1G2 NM_130463 O95670
    Mouse Atp6v1g2 NM_023179 Q9WTT4
    Rat Atp6v1g2 NM_212490 Q811A7
    ATP6V1G3 Human ATP6V1G3 NM_133326 Q96LB4
    Mouse Atp6v1g3 NM_177397 Q8BMC1
    Rat Atp6v1g3 NM_001105991 XP_213980
    ATP6V1H Human ATP6V1H NM_015941 Q9UI12
    Mouse Atp6v1h NM_133826 Q8BVE3
    Rat Atp6v1h NM_001013929 Q5XIL1
    ATP6V0A1 Human ATP6V0A1 NM_001130020 Q93050
    Mouse Atp6v0a1 NM_016920 Q9Z1G4
    Rat Atp6v0a1 NM_031604 P25286
    ATP6V0A2 Human ATP6V0A2 NM_012463 Q9Y487
    Mouse Atp6v0a2 NM_011596 P15920
    Rat Atp6v0a2 NM_053775 Q2I6B1
    ATP6V0A4 Human ATP6V0A4 NM_130840 Q9HBG4
    Mouse Atp6v0a4 NM_080467 Q920R6
    Rat Atp6v0a4 NM_001106591 XP_231615
    ATP6V0B Human ATP6V0B NM_004047 Q99437
    Mouse Atp6v0b NM_033617 Q91V37
    Rat Atp6v0b NM_001106681 XP_216510
    ATP6V0C Human ATP6V0C NM_001694 P27449
    Mouse Atp6v0c NM_009729 P63082
    Rat Atp6v0c NM_130823 P63081
    ATP6V0D1 Human ATP6V0D1 NM_004691 P61421
    Mouse Atp6v0d1 NM_013477 P51863
    Rat Atp6v0d1 NM_001011927 Q5M7T6
    ATP6V0D2 Human ATP6V0D2 NM_152565 Q8N8Y2
    Mouse Atp6v0d2 NM_175406 Q80SY3
    Rat Atp6v0d2 NM_001011972 Q5FVL0
    ATP6V0E1 Human ATP6V0E1 NM_003945 O15342
    Mouse Atp6v0e NM_025272 Q9CQD8
    Rat Atp6v0e1 NM_053578 Q794C0
    ATP6V0E2 Human ATP6V0E2 NM_145230 Q8NHE4
    Mouse Atp6v0e2 NM_133764 Q91XE7
    Rat Atp6v0e2 NM_001002253 Q5EB76