H+-ATPase (also known as vacuolar ATPase, V-ATPase) is a enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes and endosomes.

Gene Data

H+-ATPase Inhibitors

Cat. No. Product Name / Activity
1334 Bafilomycin A1
H+-ATPase (vacuolar) inhibitor
2656 Concanamycin A
H+-ATPase (vacuolar) inhibitor
3807 Disulfiram
Inhibitor of V-ATPase; displays a range of other activities

H+-ATPase Activators

Cat. No. Product Name / Activity
7474 EN6
H+ ATPase activator; activates autophagy; inactivates mTORC1 signaling

Related Targets

    H+-ATPase (also known as vacuolar ATPase, V-ATPase) is an enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes, the Golgi apparatus, chromaffin granules and coated vesicles, as well as in the plasma membrane.

    H+-ATPase is a multisubunit complex composed of two domains. The V1 domain is responsible for ATP hydrolysis and the V0 domain is responsible for protein translocation. There are two main mechanisms of regulating H+-ATPase activity; recycling of H+-ATPase-containing vesicles to and from the plasma membrane and glucose-sensitive assembly/disassembly of the holoenzyme complex.

    These transporters play an important role in processes such as receptor-mediated endocytosis, protein degradation and coupled transport. They have a function in bone reabsorption and mutations in the A3 gene cause recessive osteopetrosis. Furthermore, H+-ATPases have been implicated in tumor metastasis and regulation of sperm motility and maturation.

    External sources of pharmacological information for H+-ATPase :

      H+-ATPase Gene Data

      Gene Species Gene Symbol Gene Accession No. Protein Accession No.
      ATP6V1A Human ATP6V1A NM_001690 P38606
      Mouse Atp6v1a NM_007508 P50516
      Rat Atp6v1a NM_001108318 NP_001101788
      ATP6V1B1 Human ATP6V1B1 NM_001692 P15313
      Mouse Atp6v1b1 NM_134157 NP_598918
      Rat Atp6v1b1 NM_001107867 XP_232119
      ATP6V1B2 Human ATP6V1B2 NM_001693 P21281
      Mouse Atp6v1b2 NM_007509 P62814
      Rat Atp6v1b2 NM_057213 P62815
      ATP6V1C1 Human ATP6V1C1 NM_001695 P21283
      Mouse Atp6v1c1 NM_025494 Q9Z1G3
      Rat Atp6v1c1 NM_001011992 Q5FVI6
      ATP6V1C2 Human ATP6V1C2 NM_144583 Q8NEY4
      Mouse Atp6v1c2 NM_133699 Q99L60
      Rat Atp6v1c2 NM_001014199 Q6AYE4
      ATP6V1D Human ATP6V1D NM_015994 Q9Y5K8
      Mouse Atp6v1d NM_023721 P57746
      Rat Atp6v1d NM_199386 Q6P503
      ATP6V1E1 Human ATP6V1E1 NM_001696 P36543
      Mouse Atp6v1e1 NM_007510 P50518
      Rat Atp6v1e1 NM_198745 Q6PCU2
      ATP6V1E2 Human ATP6V1E2 NM_080653 Q96A05
      Mouse Atp6v1e2 NM_029121 Q9D593
      Rat Atp6v1e2 NM_001108979 XP_345633
      ATP6V1F Human ATP6V1F NM_004231 P06576
      Mouse Atp6v1f NM_025381 Q9D1K2
      Rat Atp6v1f NM_053884 P50408
      ATP6V1G1 Human ATP6V1G1 NM_004888 O75348
      Mouse Atp6v1g1 NM_024173 Q9CR51
      Rat Atp6v1g1 NM_001106660 XP_216411
      ATP6V1G2 Human ATP6V1G2 NM_130463 O95670
      Mouse Atp6v1g2 NM_023179 Q9WTT4
      Rat Atp6v1g2 NM_212490 Q811A7
      ATP6V1G3 Human ATP6V1G3 NM_133326 Q96LB4
      Mouse Atp6v1g3 NM_177397 Q8BMC1
      Rat Atp6v1g3 NM_001105991 XP_213980
      ATP6V1H Human ATP6V1H NM_015941 Q9UI12
      Mouse Atp6v1h NM_133826 Q8BVE3
      Rat Atp6v1h NM_001013929 Q5XIL1
      ATP6V0A1 Human ATP6V0A1 NM_001130020 Q93050
      Mouse Atp6v0a1 NM_016920 Q9Z1G4
      Rat Atp6v0a1 NM_031604 P25286
      ATP6V0A2 Human ATP6V0A2 NM_012463 Q9Y487
      Mouse Atp6v0a2 NM_011596 P15920
      Rat Atp6v0a2 NM_053775 Q2I6B1
      ATP6V0A4 Human ATP6V0A4 NM_130840 Q9HBG4
      Mouse Atp6v0a4 NM_080467 Q920R6
      Rat Atp6v0a4 NM_001106591 XP_231615
      ATP6V0B Human ATP6V0B NM_004047 Q99437
      Mouse Atp6v0b NM_033617 Q91V37
      Rat Atp6v0b NM_001106681 XP_216510
      ATP6V0C Human ATP6V0C NM_001694 P27449
      Mouse Atp6v0c NM_009729 P63082
      Rat Atp6v0c NM_130823 P63081
      ATP6V0D1 Human ATP6V0D1 NM_004691 P61421
      Mouse Atp6v0d1 NM_013477 P51863
      Rat Atp6v0d1 NM_001011927 Q5M7T6
      ATP6V0D2 Human ATP6V0D2 NM_152565 Q8N8Y2
      Mouse Atp6v0d2 NM_175406 Q80SY3
      Rat Atp6v0d2 NM_001011972 Q5FVL0
      ATP6V0E1 Human ATP6V0E1 NM_003945 O15342
      Mouse Atp6v0e NM_025272 Q9CQD8
      Rat Atp6v0e1 NM_053578 Q794C0
      ATP6V0E2 Human ATP6V0E2 NM_145230 Q8NHE4
      Mouse Atp6v0e2 NM_133764 Q91XE7
      Rat Atp6v0e2 NM_001002253 Q5EB76