Crotonic Acid

Discontinued Product

Crotonic Acid (Cat. No. 6660) has been withdrawn from sale for commercial reasons.
Description: Enhances reprogramming to pluripotency; facilitates telomere maintenance and increases telomere length
Chemical Name: (2E)-2-Butenoic acid
Purity: ≥99% (HPLC)
Literature (4)

Biological Activity for Crotonic Acid

Crotonic Acid is an induces histone modifications in chemically induced pluripotent stem cells (CiPSCs). Activates gene expression, facilitates telomere maintenance and increases telomere length, and enhances reprogramming of MEFs to iPSCs using a small molecule cocktail including valproic acid (Cat. No. 2815), CHIR 99021 (Cat. No. 4423), tranylcypromine (Cat. No. 3852), forskolin (Cat. No. 1099), AM 580 (Cat. No. 0760), EPZ 004777 (Cat. No. 5567), SGC 0946 (Cat. No. 4541) and PD 0325901 (Cat. No. 4192).

Technical Data for Crotonic Acid

M. Wt 86.09
Formula C4H6O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 107-93-7
PubChem ID 637090
Smiles C/C=C/C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Crotonic Acid

References for Crotonic Acid

References are publications that support the biological activity of the product.

Fu et al (2018) Dynamics of telomere rejuvenation during chemical induction to pluripotent stem cells. Stem Cell Reports 11 70 PMID: 29861168

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Keywords: Crotonic Acid, Crotonic Acid supplier, crotonic, acid, stem, cells, reprogramming, CiPSCs, telomere, length, maintenance, Stem, Cell, Reprogramming, 6660, Tocris Bioscience

Citations for Crotonic Acid

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Currently there are no citations for Crotonic Acid.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Stem Cell Research Product Guide

Stem Cell Research Product Guide

This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:

  • Self-renewal and Maintenance
  • Differentiation
  • Reprogramming
  • Organoid Generation
  • GMP and Ancillary Material Grade Products
Stem Cells Scientific Review

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Stem Cell Workflow Poster

Stem Cell Workflow Poster

Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.

Stem Cells Poster

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.