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Discontinued ProductCrotonic Acid (Cat. No. 6660) has been withdrawn from sale for commercial reasons.
Biological Activity for Crotonic Acid
Crotonic Acid is an induces histone modifications in chemically induced pluripotent stem cells (CiPSCs). Activates gene expression, facilitates telomere maintenance and increases telomere length, and enhances reprogramming of MEFs to iPSCs using a small molecule cocktail including valproic acid (Cat. No. 2815), CHIR 99021 (Cat. No. 4423), tranylcypromine (Cat. No. 3852), forskolin (Cat. No. 1099), AM 580 (Cat. No. 0760), EPZ 004777 (Cat. No. 5567), SGC 0946 (Cat. No. 4541) and PD 0325901 (Cat. No. 4192).
Technical Data for Crotonic Acid
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for Crotonic Acid
References are publications that support the biological activity of the product.
Fu et al (2018) Dynamics of telomere rejuvenation during chemical induction to pluripotent stem cells. Stem Cell Reports 11 70 PMID: 29861168
Keywords: Crotonic Acid, Crotonic Acid supplier, crotonic, acid, stem, cells, reprogramming, CiPSCs, telomere, length, maintenance, Stem, Cell, Reprogramming, 6660, Tocris Bioscience
Citations for Crotonic Acid
Citations are publications that use Tocris products.
Currently there are no citations for Crotonic Acid.
Reviews for Crotonic Acid
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.