cis-6-Hydroxynorketamine hydrochloride

Pricing Availability   Qty
Description: Enhances AMPA currents: antidepressant
Chemical Name: cis-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride
Purity: ≥98% (HPLC)
Citations (1)
Literature (2)

Biological Activity for cis-6-Hydroxynorketamine hydrochloride

cis-6-Hydroxynorketamine hydrochloride is a metabolite of ketamine. Increases AMPA receptor-mediated excitatory post-synaptic potentials in the CA1 region of hippocampal slices. Exhibits antidepressive effects in vivo.

2S,6S-enantiomer and 2R,6R-enantiomer also available.

Technical Data for cis-6-Hydroxynorketamine hydrochloride

M. Wt 276.16
Formula C12H14ClNO2.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 2319601-04-0
PubChem ID 121513910
Smiles ClC1=C([C@@]2(N)C([C@H](O)CCC2)=O)C=CC=C1.ClC3=C([C@]4(N)C([C@@H](O)CCC4)=O)C=CC=C3.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for cis-6-Hydroxynorketamine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 27.62 100
DMSO 27.62 100

Preparing Stock Solutions for cis-6-Hydroxynorketamine hydrochloride

The following data is based on the product molecular weight 276.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.62 mL 18.11 mL 36.21 mL
5 mM 0.72 mL 3.62 mL 7.24 mL
10 mM 0.36 mL 1.81 mL 3.62 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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Product Datasheets for cis-6-Hydroxynorketamine hydrochloride

Certificate of Analysis / Product Datasheet
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References for cis-6-Hydroxynorketamine hydrochloride

References are publications that support the biological activity of the product.

Zanos et al (2016) NMDAR inhibition-independent antidepressant actions of KA metabolites. Nature 533 481 PMID: 27144355

Leung and Baillie (1986) Comparative pharmacology in the rat of KA and its two principal metabolites, norKA and (Z)-6-hydroxynorKA. J.Med.Chem. 29 2396 PMID: 3783598

If you know of a relevant reference for cis-6-Hydroxynorketamine hydrochloride, please let us know.

Keywords: cis-6-Hydroxynorketamine hydrochloride, cis-6-Hydroxynorketamine hydrochloride supplier, ketamine, metabolite, antidepressant, depression, AMPA, HNK, Receptors, Ketamine, and, Metabolites, 5982, Tocris Bioscience

1 Citation for cis-6-Hydroxynorketamine hydrochloride

Citations are publications that use Tocris products. Selected citations for cis-6-Hydroxynorketamine hydrochloride include:

Hans-Georg et al (2019) The novel antidepressant ketamine enhances dentate gyrus proliferation with no effects on synaptic plasticity or hippocampal function in depressive-like rats. Acta Physiol (Oxf) 225 e13211 PMID: 30347138

Do you know of a great paper that uses cis-6-Hydroxynorketamine hydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.