cis-6-Hydroxynorketamine hydrochloride

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Cat.No. 5982 - cis-6-Hydroxynorketamine hydrochloride | C12H14ClNO2.HCl
Description: Enhances AMPA currents: antidepressant
Chemical Name: cis-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Metabolite of ketamine. Increases AMPA receptor-mediated excitatory post-synaptic potentials in the CA1 region of hippocampal slices. Exhibits antidepressive effects in vivo.

2S,6S-enantiomer and 2R,6R-enantiomer also available.

Technical Data

M. Wt 276.16
Formula C12H14ClNO2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
PubChem ID 121513910
InChI Key ZQJVHBJDLMIKJK-MHDYBILJSA-N
Smiles ClC1=C([C@@]2(N)C([C@H](O)CCC2)=O)C=CC=C1.ClC3=C([C@]4(N)C([C@@H](O)CCC4)=O)C=CC=C3.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 27.62 100
DMSO 27.62 100

Preparing Stock Solutions

The following data is based on the product molecular weight 276.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.62 mL 18.11 mL 36.21 mL
5 mM 0.72 mL 3.62 mL 7.24 mL
10 mM 0.36 mL 1.81 mL 3.62 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Zanos et al (2016) NMDAR inhibition-independent antidepressant actions of ketamine metabolites. Nature 533 481 PMID: 27144355

Leung and Baillie (1986) Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)-6-hydroxynorketamine. J.Med.Chem. 29 2396 PMID: 3783598


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Keywords: cis-6-Hydroxynorketamine hydrochloride, cis-6-Hydroxynorketamine hydrochloride supplier, ketamine, metabolite, antidepressant, AMPA, HNK, Receptors, Ketamine, and, Metabolites, 5982, Tocris Bioscience

Citations for cis-6-Hydroxynorketamine hydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Addiction

Addiction Poster

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Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.