cis-6-Hydroxynorketamine hydrochloride

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Cat.No. 5982 - cis-6-Hydroxynorketamine hydrochloride | C12H14ClNO2.HCl
Description: Enhances AMPA currents: antidepressant
Chemical Name: cis-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Metabolite of ketamine (Cat.No. 3131). Increases AMPA receptor-mediated excitatory post-synaptic potentials in the CA1 region of hippocampal slices. Exhibits antidepressive effects in vivo. 2S,2S- and 2R,6R-enantiomers available. 2R,6R-enantiomer lacks ketamine-related side effects.

Technical Data

M. Wt 276.16
Formula C12H14ClNO2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
PubChem ID 121513910
InChI Key ZQJVHBJDLMIKJK-MHDYBILJSA-N
Smiles ClC1=C([C@@]2(N)C([C@H](O)CCC2)=O)C=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.62 100
water 27.62 100

Preparing Stock Solutions

The following data is based on the product molecular weight 276.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.62 mL 18.11 mL 36.21 mL
5 mM 0.72 mL 3.62 mL 7.24 mL
10 mM 0.36 mL 1.81 mL 3.62 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Zanos et al (2016) NMDAR inhibition-independent antidepressant actions of ketamine metabolites. Nature 533 481 PMID: 27144355

Leung and Baillie (1986) Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)-6-hydroxynorketamine. J.Med.Chem. 29 2396 PMID: 3783598


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Keywords: ketamine metabolite antidepressant AMPA Ketamine and Metabolites

Citations for cis-6-Hydroxynorketamine hydrochloride

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Literature in this Area

Addiction

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Pathways for cis-6-Hydroxynorketamine hydrochloride

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