2R,6R-Hydroxynorketamine hydrochloride

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Cat.No. 6094 - 2R,6R-Hydroxynorketamine hydrochloride | C12H14ClNO2.HCl | CAS No. 1430202-69-9
Description: Enhances AMPA currents; decreases D-serine (a NMDA co-agonist); lacks ketamine-related side effects
Chemical Name: (2R,6R)-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride
Purity: ≥98% (HPLC)

Biological Activity

Ketamine metabolite. Enhances AMPA receptor-mediated excitatory post-synaptic potentials in the CA1 region of hippocampal slices. Decreases intracellular D-serine (a NMDA co-agonist) concentrations in PC-12 cells (IC50 = 0.68 nM). Exerts antidepressant effects in mice. Lacks ketamine-related side effects.

Licensing Information

Sold under license from the NIH, US patent 62/313,309

Technical Data

M. Wt 276.16
Formula C12H14ClNO2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1430202-69-9
PubChem ID 121513910
Smiles ClC1=C([C@@]2(N)C([C@H](O)CCC2)=O)C=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 27.62 100
water 13.81 50

Preparing Stock Solutions

The following data is based on the product molecular weight 276.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.62 mL 18.11 mL 36.21 mL
5 mM 0.72 mL 3.62 mL 7.24 mL
10 mM 0.36 mL 1.81 mL 3.62 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Singh et al (2016) Ketamine metabolites enantioselectively decrease intracellular D-serine concentrations in PC-12 cells. PLoS One 11 e0149499 PMID: 27096720

Zanos et al (2016) NMDAR inhibition-independent antidepressant actions of ketamine metabolites. Nature 533 481 PMID: 27144355

If you know of a relevant reference for 2R,6R-Hydroxynorketamine hydrochloride, please let us know.

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