2S,6S-Hydroxynorketamine hydrochloride

Pricing Availability   Qty
Description: Decreases D-serine (a NMDA co-agonist); antidepressant
Chemical Name: (2S,6S)-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride
Purity: ≥98% (HPLC)
Citations (4)
Literature (2)

Biological Activity for 2S,6S-Hydroxynorketamine hydrochloride

2S,6S-Hydroxynorketamine hydrochloride is a ketamine metabolite. Decreases intracellular D-serine (a NMDA co-agonist) concentrations in PC-12 cells (IC50 = 0.18 nM). Exerts antidepressant effects in mice.

2R,6R-Enantiomer and Racemate also available.

Licensing Information

Sold under license from the NIH, US patent 62/313,309

Technical Data for 2S,6S-Hydroxynorketamine hydrochloride

M. Wt 276.16
Formula C12H14ClNO2.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1430202-70-2
PubChem ID 124201855
Smiles ClC1=C([C@]2(N)C([C@@H](O)CCC2)=O)C=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 2S,6S-Hydroxynorketamine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 13.81 50
DMSO 27.62 100

Preparing Stock Solutions for 2S,6S-Hydroxynorketamine hydrochloride

The following data is based on the product molecular weight 276.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.62 mL 18.11 mL 36.21 mL
5 mM 0.72 mL 3.62 mL 7.24 mL
10 mM 0.36 mL 1.81 mL 3.62 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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Product Datasheets for 2S,6S-Hydroxynorketamine hydrochloride

References for 2S,6S-Hydroxynorketamine hydrochloride

References are publications that support the biological activity of the product.

Singh et al (2016) KA metabolites enantioselectively decrease intracellular D-serine concentrations in PC-12 cells. PLoS One 11 e0149499 PMID: 27096720

Zanos et al (2016) NMDAR inhibition-independent antidepressant actions of KA metabolites. Nature 533 481 PMID: 27144355

If you know of a relevant reference for 2S,6S-Hydroxynorketamine hydrochloride, please let us know.

Keywords: 2S,6S-Hydroxynorketamine hydrochloride, 2S,6S-Hydroxynorketamine hydrochloride supplier, Potent, AMPA, agonists, agonism, ketamine, metabolites, antidepressants, enantiomer, 2S,6S-HNK, depression, Receptors, NMDA, Ketamine, and, Metabolites, 6095, Tocris Bioscience

4 Citations for 2S,6S-Hydroxynorketamine hydrochloride

Citations are publications that use Tocris products. Selected citations for 2S,6S-Hydroxynorketamine hydrochloride include:

Ago et al (2019) (R)-Ketamine induces a greater increase in prefrontal 5-HT release than (S)-Ketamine and Ketamine Metabolites via an AMPA receptor-independent mechanism. Int J Neuropsychopharmacol 22 665 PMID: 31325908

Ye et al (2019) KA metabolite (2R,6R)-hydroxynorKA enhances aggression via periaqueductal gray glutamatergic transmission. Neuropharmacology 157 PMID: 31207251

Eero et al (2022) Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro. Front Pharmacol 12 755600 PMID: 35126106

Chou et al (2018) (2R,6R)-hydroxynorKA rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray. Neuropharmacology 139 1 PMID: 29953886

Do you know of a great paper that uses 2S,6S-Hydroxynorketamine hydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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