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Cat.No. 6997 - BOP-JF646 | C57H59N9O10SSi
Description: Red fluorescent dual α9β1/α4β1 integrin inhibitor comprising BOP conjugated to Janelia Fluor® 646; fluorogenic; photostable
Chemical Name: 2-(3-(Azetidin-1-ium-1-ylidene)-7-(azetidin-1-yl)-5,5-dimethyl-3,5-dihydrodibenzo[b,e]silin-10-yl)-5-(((1-((3R,5S)-5-(((S)-1-carboxy-2-(4-((pyrrolidine-1-carbonyl)oxy)phenyl)ethyl)carbamoyl)-1-(phenylsulfonyl)pyrrolidin-3-yl)-1H-1,2,3-triazol-4-yl)methyl)carbamoyl)benzoate
Purity: ≥90% (HPLC)
Literature (1)

Biological Activity

Fluorescent dual α9β1/α4β1 integrin inhibitor. Comprises BOP (Cat. No. 6047) conjugated to Janelia Fluor® 646 (Cat. No. 6148). Fluorogenic: fluoresces only once bound to integrins, enabling hassle-free no-wash experiments. Bright and photostable, enabling live cell tracking of integrin receptors over long time-course experiments. Excitation maximum = 655 nm; emission maximum = 672 nm.

Application of BOP-JF646 in Immortalized Human Keratinocyte Cells

Application of BOP-JF646

Immortalized human keratinocyte cells expressing a GFP-tagged α4 integrin were treated with 10 μM BOP-Janelia Fluor® 646. Cells were incubated at 37°C and imaged using a Nikon A1R confocal microscope. Scale bar = 10 μm.

Image kindly provided by Willow Hight-Warburton, Kings College London.

Optical Data for BOP-JF646

Emission Color Red
λabs 655 nm
λem 672 nm
Closest Laser line 647 nm
Application Flow Cytometry, Confocal Microscopy, super resolution microscopy (SRM)

Technical Data

M. Wt 1090.3
Formula C57H59N9O10SSi
Storage Store at -20°C
Purity ≥90% (HPLC)
Smiles OC([C@@H](NC([C@@H]1C[C@@H](N2C=C(CNC(C3=CC=C(C([O-])=O)C(C(C4=CC=C(N5CCC5)C=C4[Si]6(C)C)=C(C=C/7)C6=CC7=[N+]8CCC\8)=C3)=O)N=N2)CN1S(=O)(C9=CC=CC=C9)=O)=O)CC%10=CC=C(C=C%10)OC(N%11CCCC%11)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.


References are publications that support the biological activity of the product.

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Keywords: BOP-JF646, BOP-JF646 supplier, Fluorescent, dual, α9β1/α4β1, integrins, inhibitors, BOP, labels, stains, HSC, progenitors, hematopoietic, stem, cells, Integrins, Stem, Cell, Signaling, Integrin, Probes, 6997, Tocris Bioscience

Citations for BOP-JF646

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