[Leu5]-Enkephalin

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Cat.No. 1889 - [Leu5]-Enkephalin | Tyr-Gly-Gly-Phe-Leu | CAS No. 58822-25-6
Description: Endogenous opioid agonist peptide
Alternative Names: ICI 114740, Dynorphin-(1-5), YGGFL
Datasheet
Citations (1)
Literature

Biological Activity

Endogenous opioid agonist peptide; inhibits electrically stimulated contractions in mouse vas deferens (IC50 = 11.4 nM). Short-acting in vivo.

Technical Data

M. Wt 555.63
Formula C28H37N5O7
Sequence YGGFL
Storage Desiccate at -20°C
CAS Number 58822-25-6
PubChem ID 461776
InChI Key URLZCHNOLZSCCA-VABKMULXSA-N
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 555.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.8 mL 9 mL 18 mL
5 mM 0.36 mL 1.8 mL 3.6 mL
10 mM 0.18 mL 0.9 mL 1.8 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

DiMaio et al (1982) Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogues: effect of conformational constraints on opiate receptor selectivity. J.Med.Chem. 25 1432 PMID: 6296388

Law and Loh (1978) 3H-Leu5-enkephalin specific binding to synaptic membrane - comparison with 3H-dihydromorphine and 3H-naloxone. Res.Commun.Chem.Pathol.Pharmacol. 21 409 PMID: 705021

Meunier et al (1977) Binding of Leu5-enkephalin and Met5-enkephalin to a particulate fraction from rat cerebrum. FEBS Lett. 77 209 PMID: 862920


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Keywords: [Leu5]-Enkephalin, supplier, Endogenous, opioids, agonists, peptide, Receptors, ICI114740, enkephalin, ICI, 114740, Dynorphin-(1-5), YGGFL, Miscellaneous/Non-selective, Opioids, Tocris Bioscience

1 Citation for [Leu5]-Enkephalin

Citations are publications that use Tocris products. Selected citations for [Leu5]-Enkephalin include:

Markkanen and Petäjä-Repo (2008) N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface. J Biol Chem 283 29086 PMID: 18703511


Do you know of a great paper that uses [Leu5]-Enkephalin from Tocris? If so please let us know.

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