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Description: Endogenous opioid agonist peptide
Alternative Names: ICI 114740,Dynorphin-(1-5),YGGFL
Purity: ≥95% (HPLC)
Citations (1)
Literature (2)

Biological Activity for [Leu5]-Enkephalin

[Leu5]-Enkephalin is an endogenous opioid agonist peptide; inhibits electrically stimulated contractions in mouse vas deferens (IC50 = 11.4 nM). Short-acting in vivo.

Technical Data for [Leu5]-Enkephalin

M. Wt 555.63
Formula C28H37N5O7
Sequence YGGFL
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 58822-25-6
PubChem ID 461776
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for [Leu5]-Enkephalin

Solubility Soluble to 1 mg/ml in water

Product Datasheets for [Leu5]-Enkephalin

Certificate of Analysis / Product Datasheet
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References for [Leu5]-Enkephalin

References are publications that support the biological activity of the product.

DiMaio et al (1982) Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogues: effect of conformational constraints on opiate receptor selectivity. J.Med.Chem. 25 1432 PMID: 6296388

Law and Loh (1978) 3H-Leu5-enkephalin specific binding to synaptic membrane - comparison with 3H-dihydromorphine and 3H-naloxone. Res.Commun.Chem.Pathol.Pharmacol. 21 409 PMID: 705021

Meunier et al (1977) Binding of Leu5-enkephalin and Met5-enkephalin to a particulate fraction from rat cerebrum. FEBS Lett. 77 209 PMID: 862920

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Keywords: [Leu5]-Enkephalin, [Leu5]-Enkephalin supplier, Endogenous, opioids, agonists, peptide, Receptors, ICI114740, enkephalin, ICI, 114740, Dynorphin-(1-5), YGGFL, Miscellaneous/Non-selective, Opioids, 1889, Tocris Bioscience

1 Citation for [Leu5]-Enkephalin

Citations are publications that use Tocris products. Selected citations for [Leu5]-Enkephalin include:

Markkanen and Petäjä-Repo (2008) N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface. J Biol Chem 283 29086 PMID: 18703511

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

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Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.