[Leu5]-Enkephalin

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Cat.No. 1889 - [Leu5]-Enkephalin | Tyr-Gly-Gly-Phe-Leu | CAS No. 58822-25-6
Description: Endogenous opioid agonist peptide
Alternative Names: ICI 114740, Dynorphin-(1-5), YGGFL
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Endogenous opioid agonist peptide; inhibits electrically stimulated contractions in mouse vas deferens (IC50 = 11.4 nM). Short-acting in vivo.

Technical Data

M. Wt 555.63
Formula C28H37N5O7
Sequence YGGFL
Storage Desiccate at -20°C
CAS Number 58822-25-6
PubChem ID 461776
InChI Key URLZCHNOLZSCCA-VABKMULXSA-N
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

DiMaio et al (1982) Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogues: effect of conformational constraints on opiate receptor selectivity. J.Med.Chem. 25 1432 PMID: 6296388

Law and Loh (1978) 3H-Leu5-enkephalin specific binding to synaptic membrane - comparison with 3H-dihydromorphine and 3H-naloxone. Res.Commun.Chem.Pathol.Pharmacol. 21 409 PMID: 705021

Meunier et al (1977) Binding of Leu5-enkephalin and Met5-enkephalin to a particulate fraction from rat cerebrum. FEBS Lett. 77 209 PMID: 862920


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Keywords: [Leu5]-Enkephalin, [Leu5]-Enkephalin supplier, Endogenous, opioids, agonists, peptide, Receptors, ICI114740, enkephalin, ICI, 114740, Dynorphin-(1-5), YGGFL, Miscellaneous/Non-selective, Opioids, 1889, Tocris Bioscience

1 Citation for [Leu5]-Enkephalin

Citations are publications that use Tocris products. Selected citations for [Leu5]-Enkephalin include:

Markkanen and Petäjä-Repo (2008) N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface. J Biol Chem 283 29086 PMID: 18703511


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