BAPTA

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Cat.No. 2786 - BAPTA | C22H24N2O10 | CAS No. 85233-19-8
Description: Selective calcium chelator
Chemical Name: 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid
Purity: ≥95% (HPLC)
Datasheet
Citations (10)
Literature

Biological Activity

Selective calcium chelator.

Technical Data

M. Wt 476.23
Formula C22H24N2O10
Storage Store at +4°C
Purity ≥95% (HPLC)
CAS Number 85233-19-8
PubChem ID 104751
InChI Key FTEDXVNDVHYDQW-UHFFFAOYSA-N
Smiles OC(=O)CN(CC(O)=O)C1=CC=CC=C1OCCOC1=C(C=CC=C1)N(CC(O)=O)CC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
sodium bicarbonate (0.3N) 23.81 50

Preparing Stock Solutions

The following data is based on the product molecular weight 476.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.1 mL 10.5 mL 21 mL
5 mM 0.42 mL 2.1 mL 4.2 mL
10 mM 0.21 mL 1.05 mL 2.1 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hardie (2005) Inhibition of phospholipase C activity in Drosophila photoreceptors by 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid (BAPTA) and di-bromo BAPTA. Cell Calcium 38 547 PMID: 16140375


If you know of a relevant reference for BAPTA, please let us know.

Keywords: BAPTA, supplier, Selective, Ca2+, chelator, calcium, Signaling, Signalling, Agents, General, Reagents, General, Calcium, Signaling, Agents, Biochemicals, and, Molecular, Biology, Biochemicals, and, Molecular, Biology, Tocris Bioscience

10 Citations for BAPTA

Citations are publications that use Tocris products. Selected citations for BAPTA include:

Mirante et al (2014) Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala. Cell Death Dis 7 62 PMID: 25071439

Alpert and Alford (2013) Synaptic NMDA receptor-dependent Ca2+ entry drives membrane potential and Ca2+ oscillations in spinal ventral horn neurons. PLoS One 8 e63154 PMID: 23646190

Navarrete et al (2012) Astrocytes mediate in vivo cholinergic-induced synaptic plasticity. PLoS Biol 10 e1001259 PMID: 22347811

Arozarena et al (2011) Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A. Cancer Cell 19 45 PMID: 21215707

Pleil et al (2015) NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking. Nat Neurosci 18 545 PMID: 25751534

Tabatadze et al (2015) Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus. J Neurosci 35 11252 PMID: 26269634

Birnbaum et al (2015) Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss. PLoS One 6 e1791 PMID: 26086964

Vemana et al (2015) A critical role for the transient receptor potential channel type 6 in human platelet activation. Cell Commun Signal 10 e0125764 PMID: 25928636

Carlsen and Perrier (2014) Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord. Front Neural Circuits 8 60 PMID: 24926236

Reneau et al (2009) Phorbol 12-myristate 13-acetate potentiation of N-methyl-D-aspartate-induced currents in primary cultured cerebellar granule cells is mediated by protein kinase C alpha. J Pharmacol Exp Ther 330 641 PMID: 19429793


Do you know of a great paper that uses BAPTA from Tocris? If so please let us know.

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