Pricing Availability   Qty
Description: Selective VIP receptor antagonist
Purity: ≥95% (HPLC)
Citations (4)

Biological Activity for [D-p-Cl-Phe6,Leu17]-VIP

[D-p-Cl-Phe6,Leu17]-VIP is a selective vasoactive intestinal peptide (VIP) receptor antagonist (IC50 = 125.8 nM). Displays no activity on glucagon, secretin or GRF receptors.

Technical Data for [D-p-Cl-Phe6,Leu17]-VIP

M. Wt 3342.24
Formula C148H239ClN44O42

(Modifications: Phe-6 = p-Cl-D-Phe, Asn-34 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 102805-45-8
PubChem ID 90488798
Smiles [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](CC1=CC=C(Cl)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for [D-p-Cl-Phe6,Leu17]-VIP

Solubility Soluble to 1 mg/ml in water

Product Datasheets for [D-p-Cl-Phe6,Leu17]-VIP

Certificate of Analysis / Product Datasheet
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References for [D-p-Cl-Phe6,Leu17]-VIP

References are publications that support the biological activity of the product.

Pandol et al (1986) Vasoactive intestinal peptide receptor antagonist [4Cl-D-Phe6,Leu17]VIP. Am.J.Physiol. 250 G553 PMID: 2421587

Pozo et al (1997) Characterization of VIP receptor-effector system antagonists in rat and mouse peritoneal macrophages. Eur.J.Pharmacol. 321 379 PMID: 9085051

Xie et al (2007) Vasoactive intestinal peptide transactivates the androgen receptor through a protein kinase A-dependent extracellular signal-regulated kinase pathway in prostate cancer LNCaP cells. Mol.Pharmacol. 72 73 PMID: 17430995

If you know of a relevant reference for [D-p-Cl-Phe6,Leu17]-VIP, please let us know.

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Keywords: [D-p-Cl-Phe6,Leu17]-VIP, [D-p-Cl-Phe6,Leu17]-VIP supplier, Selective, VIP, receptor, antagonists, Vasoactive, Intestinal, Peptide, Receptors, VPAC, 3054, Tocris Bioscience

4 Citations for [D-p-Cl-Phe6,Leu17]-VIP

Citations are publications that use Tocris products. Selected citations for [D-p-Cl-Phe6,Leu17]-VIP include:

Maugeri et al (2016) PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression. Sci Rep 7 139 PMID: 27303300

Nedvetsky et al (2014) Parasympathetic innervation regulates tubulogenesis in the developing salivary gland. Dev Cell 30 449 PMID: 25158854

Jones et al (2015) Manipulating circadian clock neuron firing rate resets molecular circadian rhythms and behavior. Nat Neurosci 18 373 PMID: 25643294

Evans et al (2013) Dynamic interactions mediated by nonredundant signaling mechanisms couple circadian clock neurons. Neuron 80 973 PMID: 24267653

Do you know of a great paper that uses [D-p-Cl-Phe6,Leu17]-VIP from Tocris? Please let us know.

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