VIP (human, rat, mouse, rabbit, canine, porcine)

Pricing Availability Delivery Time Qty
Cat.No. 1911 - VIP (human, rat, mouse, rabbit, canine, porcine) | His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2 | CAS No. 40077-57-4
Description: Involved in neurotransmission and smooth muscle relaxation
Alternative Names: Vasoactive Intestinal Peptide (human, rat, mouse, rabbit, canine, porcine)
Datasheet
Citations (2)
Literature

Biological Activity

Neuropeptide with many biological actions; plays a role in neurotransmission, smooth muscle relaxation and has trophic and mitogenic actions.

Technical Data

M. Wt 3325.83
Formula C147H238N44O42S
Sequence HSDAVFTDNYTRLRKQMAVKKYLNSILN

(Modifications: Asn-28 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 40077-57-4
PubChem ID 16140438
InChI Key HEOYHMUESMJFDC-RIWXPGAOSA-N
Smiles [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 3325.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.3 mL 1.5 mL 3.01 mL
5 mM 0.06 mL 0.3 mL 0.6 mL
10 mM 0.03 mL 0.15 mL 0.3 mL
50 mM 0.01 mL 0.03 mL 0.06 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Harmar et al (1998) International Union of Pharmacology. XVIII. Nomenclature of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide. Pharmacol.Rev. 50 265 PMID: 9647867

Laburthe and Couvineau (2002) Molecular pharmacology and structure of VPAC receptors for VIP and PACAP. Regul.Pept. 108 165 PMID: 12220741


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Keywords: VIP (human, rat, mouse, rabbit, canine, porcine), supplier, Involved, neurotransmission, smooth, muscle, relaxation, Vasoactive, Intestinal, Peptide, Receptors, VPAC, VIP, agonists, Vasoactive, Intestinal, Peptide, (human,, rat,, mouse,, rabbit,, canine,, porcine), VIP, Receptors, VIP, Receptors, Tocris Bioscience

2 Citations for VIP (human, rat, mouse, rabbit, canine, porcine)

Citations are publications that use Tocris products. Selected citations for VIP (human, rat, mouse, rabbit, canine, porcine) include:

Piet et al (2016) Vasoactive Intestinal Peptide Excites GnRH Neurons in Male and Female Mice. Endocrinology. 157 3621 PMID: 27501185

Alcolado et al (2014) Cystic fibrosis transmembrane conductance regulator dysfunction in VIP knockout mice. Am J Physiol Cell Physiol 307 C195 PMID: 24898584


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