Urokinase

Urokinase (also known as urokinase-type plasminogen activator, uPA) is a serine protease that catalyzes the conversion of plasminogen to plasmin. uPA interacts with a cell surface receptor known as the urokinase receptor (uPAR) to restrict plasminogen activation.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
0890 Amiloride hydrochloride
Urokinase-type plasminogen activator (UPA) inhibitor
4372 BC 11 hydrobromide
Selective urokinase (uPA) inhibitor
0442 4-Chlorophenylguanidine hydrochloride
Urokinase inhibitor

Urokinase (also known as urokinase-type plasminogen activator, uPA) is a serine protease that catalyzes the conversion of plasminogen to plasmin. uPA interacts with a receptor present on cell membranes known as the urokinase receptor (uPAR). This interaction restricts plasminogen activation to the vicinity of the cell surface and also initiates various signal transduction cascades within the cell. Urokinase activity influences extracellular matrix remodeling, cell adhesion, migration and invasion, making it a therapeutic target of interest for cancer research.

Urokinase activity is inhibited by two serine protease inhibitors - plasminogen activator inhibitor-1 and -2 (PAI-1 and PAI-2). PAI-1 induces the internalization of the uPA-uPAR complex and recycling of uPAR; PAI-2 also complexes with uPA-uPAR but is not internalized. Expression of the uPA receptor varies between cell types, and it is often overexpressed by malignant tumor cells.

Literature for Urokinase

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure

Urokinase Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
PLAU Human PLAU NM_001145031 P00749
Mouse Plau NM_008873 P06869
Rat Plau NM_013085 Q3KR76