4-Chlorophenylguanidine hydrochloride

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Description: Urokinase inhibitor
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for 4-Chlorophenylguanidine hydrochloride

4-Chlorophenylguanidine hydrochloride is a potent and specific inhibitor of urokinase. Also a positive allosteric modulator at acid sensing ion channel 3 (ASIC3), which increases its pH sensitivity.

Technical Data for 4-Chlorophenylguanidine hydrochloride

M. Wt 206.07
Formula C7H8ClN3.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 14279-91-5
PubChem ID 44134626
Smiles Cl.NC(=N)NC1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 4-Chlorophenylguanidine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 100

Preparing Stock Solutions for 4-Chlorophenylguanidine hydrochloride

The following data is based on the product molecular weight 206.07. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.85 mL 24.26 mL 48.53 mL
5 mM 0.97 mL 4.85 mL 9.71 mL
10 mM 0.49 mL 2.43 mL 4.85 mL
50 mM 0.1 mL 0.49 mL 0.97 mL

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Product Datasheets for 4-Chlorophenylguanidine hydrochloride

Certificate of Analysis / Product Datasheet
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References for 4-Chlorophenylguanidine hydrochloride

References are publications that support the biological activity of the product.

Yang et al (1990) Selective inhibition of urok. by substituted phenylguanidines: quantitative structure-activity relationship analyses. J.Med.Chem. 33 2956 PMID: 2231595

Agharkar & Gonzales (2017) 4-Chlorophenylguanidine is an ASIC3 agonist and positive allosteric modulator. J.Pharmacol.Sci. 133 184 PMID: 28259560

If you know of a relevant reference for 4-Chlorophenylguanidine hydrochloride, please let us know.

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1 Citation for 4-Chlorophenylguanidine hydrochloride

Citations are publications that use Tocris products. Selected citations for 4-Chlorophenylguanidine hydrochloride include:

Agharkar & Gonzales 4-Chlorophenylguanidine is an ASIC3 agonist and positive allosteric modulator. J.Pharmacol.Sci. 133 184 PMID: 28259560

Do you know of a great paper that uses 4-Chlorophenylguanidine hydrochloride from Tocris? Please let us know.

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