4-Chlorophenylguanidine hydrochloride

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Cat.No. 0442 - 4-Chlorophenylguanidine hydrochloride | C7H8ClN3.HCl | CAS No. 14279-91-5
Description: Urokinase inhibitor
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)

Biological Activity

Potent and specific inhibitor of urokinase. Also a positive allosteric modulator at acid sensing ion channel 3 (ASIC3), which increases its pH sensitivity.

Technical Data

M. Wt 206.07
Formula C7H8ClN3.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 14279-91-5
PubChem ID 44134626
InChI Key RMFZXBDENVVLSL-UHFFFAOYSA-N
Smiles Cl.NC(=N)NC1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 100 mM in water

References

References are publications that support the biological activity of the product.

Yang et al (1990) Selective inhibition of urok. by substituted phenylguanidines: quantitative structure-activity relationship analyses. J.Med.Chem. 33 2956 PMID: 2231595

Agharkar & Gonzales (2017) 4-Chlorophenylguanidine is an ASIC3 agonist and positive allosteric modulator. J.Pharmacol.Sci. 133 184 PMID: 28259560


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Keywords: 4-Chlorophenylguanidine hydrochloride, 4-Chlorophenylguanidine hydrochloride supplier, Urokinase, inhibitors, inhibits, Proteases, Proteinases, upa, PAM, ASIC, 0442, Tocris Bioscience

1 Citation for 4-Chlorophenylguanidine hydrochloride

Citations are publications that use Tocris products. Selected citations for 4-Chlorophenylguanidine hydrochloride include:

Agharkar & Gonzales 4-Chlorophenylguanidine is an ASIC3 agonist and positive allosteric modulator. J.Pharmacol.Sci. 133 184 PMID: 28259560


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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