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Biological Activity for 4-Chlorophenylguanidine hydrochloride
4-Chlorophenylguanidine hydrochloride is a potent and specific inhibitor of urokinase. Also a positive allosteric modulator at acid sensing ion channel 3 (ASIC3), which increases its pH sensitivity.
Technical Data for 4-Chlorophenylguanidine hydrochloride
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 4-Chlorophenylguanidine hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for 4-Chlorophenylguanidine hydrochloride
The following data is based on the product molecular weight 206.07. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.85 mL||24.26 mL||48.53 mL|
|5 mM||0.97 mL||4.85 mL||9.71 mL|
|10 mM||0.49 mL||2.43 mL||4.85 mL|
|50 mM||0.1 mL||0.49 mL||0.97 mL|
Product Datasheets for 4-Chlorophenylguanidine hydrochloride
References for 4-Chlorophenylguanidine hydrochloride
References are publications that support the biological activity of the product.
Yang et al (1990) Selective inhibition of urok. by substituted phenylguanidines: quantitative structure-activity relationship analyses. J.Med.Chem. 33 2956 PMID: 2231595
Agharkar & Gonzales (2017) 4-Chlorophenylguanidine is an ASIC3 agonist and positive allosteric modulator. J.Pharmacol.Sci. 133 184 PMID: 28259560
If you know of a relevant reference for 4-Chlorophenylguanidine hydrochloride, please let us know.
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Keywords: 4-Chlorophenylguanidine hydrochloride, 4-Chlorophenylguanidine hydrochloride supplier, Urokinase, inhibitors, inhibits, Proteases, Proteinases, upa, PAM, ASIC, 0442, Tocris Bioscience
1 Citation for 4-Chlorophenylguanidine hydrochloride
Citations are publications that use Tocris products. Selected citations for 4-Chlorophenylguanidine hydrochloride include:
Agharkar & Gonzales 4-Chlorophenylguanidine is an ASIC3 agonist and positive allosteric modulator. J.Pharmacol.Sci. 133 184 PMID: 28259560
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Literature in this Area
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